Serum Cardiac Troponin T in Adolescent Runners: Effects of Exercise Intensity and Duration

Abstract

The purpose of this study was to evaluate the interactive effects of exercise duration and intensity on the elevation of serum cardiac troponin T (cTnT) in trained adolescent athletes following prolonged exercise in a laboratory-based setting. Thirteen male adolescent runners (mean age 14.8+/-1.6 year) performed two 45-min and two 90-min constant-load treadmill runs with intensities set at the running speeds that corresponded to either 80% or 100% ventilatory threshold (Th(vent)): 80%Th(vent)45 min, 80%Th(vent)90 min, 100%Th(vent)45 min and 100%Th(vent)90 min. Serum cTnT was assessed pre and post exercise. In the 100%Th(vent)45 min trial, the post-exercise serum cTnT level [(Median) 0.015 ng x ml(-1); (Range)<0.01-0.375 ng x ml(-1)] was greater than that of the 80%Th(vent)45 min (undetectable cTnT) and 80%Th(vent)90 min (detectable cTnT in two subjects, 0.021 and 0.133 ng x ml(-1)) trials (P<0.01). The serum cTnT level was further increased in the 100%Th(vent)90 min trial [(Median) 0.063 ng x ml(-1); (Range)<0.01-0.417 ng x ml(-1)] when the treadmill run was sustained for an additional 45 min (P<0.05). Similar changes were observed in the cTnT positive rate in subjects. These findings suggest that exercise duration and intensity are essential factors in eliciting cTnT release interactively following an endurance exercise. Nevertheless, exercise intensity compared to duration appears to cause a more pronounced increase in cTnT levels.

The impact of exercise intensity on the release of cardiac biomarkers in marathon runners

“…This supports previous findings for shorter exercise durations (Fu et al 2009;Serrano-Ostáriz et al 2011) and the indirect evidence from a recent metaanalysis (Shave et al 2007b). When running the marathon at competition intensity (HR difference of c. 15 beats min -1 ) 6 out of 14 athletes exceeded the URL for cTnI.…”

Cardiac troponin I release after a basketball match in elite, amateur and junior players

“…This percentage is lower than reported after endurance events, such as marathon [7] or cycling [3], and the more modest changes in the current study likely reflect the low total exercise duration and volume compared to many previous endurance and ultra-endurance activities [7]. Previous studies have noted that the increase in cTnI or cTnT is mainly mediated by the exercise duration when the intensity is controlled [5,28].…”

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

“…The kinetic profile of cTnI and cTnT circulating levels after strenuous exercise in apparently healthy subjects [25,40,[52][53][54][55][56][77][78][79][80][81][82][83][84][85][86][87][88][89][90] is different from that usually observed in patients with AMI. It is well known that circulating levels of cTnI and cTnT in patients with uncomplicated type 1 AMI usually peak between 12 and 36 h from beginning of thoracic pain, gradually returning to below the 99th URL value within 5-7 days [1,3,40,76].…”