Serum cardiac troponin I in dogs with primary immune-mediated haemolytic anaemia

Gow, Deborah J.; Gow, Adam; Bell, R.; Spratt, David P.; Cash, R. S. G.; Ricketts, S. W.; Archer, Joy; Mellanby, Richard J.

doi:10.1111/j.1748-5827.2011.01061.x

Cited by 18 publications

(20 citation statements)

References 39 publications

(60 reference statements)

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“…Myocardial affectation in protozoan diseases is very rare . However, cardiac involvement of some hemolytic infectious diseases such as equine piroplasmosis, babesiosis, and trypanosomiasis in dog, primary immune‐mediated hemolytic anemia and ehrlichiosis in dog had been studied. However, in these studies there is clear potential for the infectious agent to cause direct myocyte damage and thereby making it difficult to objectively establish whether anemia per se is inducing cardiac myocyte damage or not.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Cardiac Troponin I in Cattle with Theileriosis

Fartashvand

Nadalian

Sakha

et al. 2012

Veterinary Internal Medicne

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Background: Theileria annulata is a blood parasite affecting ruminants. Hemolytic anemia, secondary hypoxia, and vasculitis are the most important features of tropical theileriosis.Objectives: Evaluation of electrocardiographic findings and changes in cardiovascular biochemical markers including cTnI concentrations in cattle naturally infected with theileriosis in the absence of acute cardiac failure.Animals: Ninety adult Holstein cattle (>1 year) with clinical and laboratory evidence of theileriosis and 30 healthy cattle served as controls.Methods: Case-control study in which blood samples were collected and randomized after clinical, hematologic, parasitologic examination and laboratory confirmation and electrocardiographic recording on all animals, serum cardiac troponin I (cTnI), aspartate aminotransferase (AST), and creatine kinase-MB (CK-MB) were evaluated.Results: Serum concentration of cTnI was significantly higher in cattle with theileriosis (mean: 0.028 ng/mL; range: 0.005-0.21 ng/mL; control mean: 0.011; range: <0.005-0.09 ng/mL; P = .003). There was significant correlation between serum level of cTnI and PCV (r = À0.257; P < .001) and also between cTnI and parasitemia (r = 0.515; P < .001). Mean serum activities of AST and CK-MB were 107 ± 46 and 301 ± 103 U/L in sick animals, which were significantly higher than healthy cattle (P = .002 and P = .041, respectively). There were no pathologic arrhythmias detected in sick animals.Conclusions and Clinical Importance: Theileriosis is a risk factor for elevation of cardiac biomarkers in naturally infected Holstein cattle. Severity of anemia and parasitemia might contribute to the pathophysiology of myocardial damage. The prognostic significance of increased serum cardiac troponin I concentrations in cattle with hemolytic anemia merits further investigation.

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Section: Discussionmentioning

confidence: 99%

Elevated Serum Cardiac Troponin I in Cattle with Theileriosis

Fartashvand

Nadalian

Sakha

et al. 2012

Veterinary Internal Medicne

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“…This approach has previously been used to examine the prevalence of myocyte damage in dogs with primary IMHA (Gow et al. ). Similar to the key finding of this study in cats, the earlier work in dogs with primary IMHA also found that anaemic dogs had a significantly higher cTnI concentration compared to non‐anaemic, ill dogs (Gow et al.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to the key finding of this study in cats, the earlier work in dogs with primary IMHA also found that anaemic dogs had a significantly higher cTnI concentration compared to non‐anaemic, ill dogs (Gow et al. ).…”

Section: Discussionmentioning

confidence: 99%

Serum Cardiac Troponin I concentrations in cats with anaemia – a preliminary, single‐centre observational study

Lalor

Gunn-Moore

Cash

et al. 2014

J of Small Animal Practice

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“…Dogs with other etiologies for anemia showed higher levels of cardiac troponin I (GOW et al, 2011). Moreover, with an increase in sympathetic activation, the time of diastole is reduced, and this may impair coronary perfusion and increased myocardial oxygen consumption (CRUVINEL; CASTRO, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the cardiac biomarkers are being used in various clinical situations to assess the degree of myocardial injury in heart disease in several clinical situations in which myocardial lesions can be related to non-cardiac injuries and anemia as babesiosis (LOBETTI; DVIR; PEARSON, 2002;LOBETTI, 2005) ehrlichiosis (DINIZ et al, 2008) and immune-mediated hemolytic anemia (GOW et al, 2011). Higher serum concentrations of cardiac troponin I in dogs with primary hemolytic anemia than hospitalized ill dogs or healthy dogs revealed that anemia can promote subclinical myocyte damage (GOW et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Electrocardiographic evaluation and serum cardiac troponin I levels in anemic dogs with blood parasitosis

et al. 2013

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Blood parasitosis is a frequent cause of anemia and myocarditis in dogs. Because anemia can trigger hypoxia or hemodynamic disturbances and myocarditis secondary to blood parasitosis can develop arrhythmias, electrocardiogram changes and increased levels of cardiac biomarkers, such as cardiac troponin I, are expected in dogs with blood parasitosis. Thus, this study aimed to investigate the electrocardiographic characteristics and the relationship to troponin I levels in anemic dogs with blood parasitosis. Twenty-eight dogs with blood parasitosis (seropositive for Ehrlichia canis/ Babesia canis) and varying levels of anemia were evaluated. Dogs with very severe anemia (hematocrit below 13%) showed significant increases in heart rate when compared to dogs with severe, moderate or mild anemia. There was a predominance of respiratory sinus arrhythmia in dogs with mild, moderate and severe anemia and a high prevalence of sinus rhythm in dogs with very severe anemia, which showed a decrease in parasympathetic activity in this group. In all of the groups, electrocardiographic changes were detected showing compatibility with left and right atrial and left ventricular enlargement. Dogs with very severe anemia had a longer P wave duration. All groups of anemic dogs showed increased T-wave amplitude, suggestive of myocardial hypoxia. However, only the groups with moderate and severe anemia presented ST segment disturbances. Despite the lack of a correlation between the electrocardiographic changes suggestive of myocardial hypoxia and troponin I, there was a negative correlation (r = -0.95, p = 0.05) between hemoglobin levels and increased serum troponin. These data indicate that anemic dogs with blood parasitosis may have electrocardiographic changes suggestive of atrioventricular overload or hemodynamic disturbances, such as increased heart rate. Moreover, the negative correlation between hemoglobin and serum levels of troponin I may imply that dogs with severe and very severe anemia are at a higher risk for myocardial injury. Key words: Cardiac biomarker, electrocardiogram; hematocrit, myocardial hypoxia ResumoHemoparasitoses são causas frequentes de anemia e miocardite em cães. Em virtude da anemia poder provocar distúrbios hemodinâmicos relacionados à hipóxia e da miocardite secundária à hemoparasitose causar arritmias cardíacas, esperam-se alterações eletrocardiográficas e aumento dos níveis de biomarcadores cardíacos como troponina I cardíaca em cães com hemoparasitose. Por conseguinte, este estudo teve como objetivo investigar as características eletrocardiográficas de cães anêmicos por hemoparasitose e a relação da anemia com alterações eletrocardiográficas e aumento da troponina I cardíaca. Para tanto, foram avaliados vinte e oito cães com hemoparasitose, sorologicamente positivos para Ehrlichia canis/ Babesia canis, com diferentes níveis de anemia. Cães com anemia muito grave (hematócrito abaixo de 13%) apresentaram aumentos significativos da frequência cardíaca, comparados aos cães com anemia grave, mode...

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Serum cardiac troponin I in dogs with primary immune-mediated haemolytic anaemia

Cited by 18 publications

References 39 publications

Elevated Serum Cardiac Troponin I in Cattle with Theileriosis

Elevated Serum Cardiac Troponin I in Cattle with Theileriosis

Serum Cardiac Troponin I concentrations in cats with anaemia – a preliminary, single‐centre observational study

Electrocardiographic evaluation and serum cardiac troponin I levels in anemic dogs with blood parasitosis

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