Serum carcinoembryonic antigen-related cell adhesion molecule 1 level in postmenopausal women: correlation with β-catenin and bone mineral density

Ma, Chen; Shuai, Bo; Shen, Lin; Yang, Yanping; Xu, Xizhen; Li, C. G.

doi:10.1007/s00198-015-3408-3

Cited by 2 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Degradation of β-catenin by the destruction complex is a diagnostic pathway from Module 4. Numerous studies have indicated the association between β-catenin and PO ( 41 – 44 ). In the present study, the diagnostic module-associated pathways were in accordance with the pathological process of PO, which indirectly indicates the feasibility of the application of the present method.…”

Section: Discussionmentioning

confidence: 99%

Systemic tracking of diagnostic function modules for post-menopausal osteoporosis in a differential co-expression network view

Wang

Luo³

2018

Exp Ther Med

View full text Add to dashboard Cite

Post-menopausal osteoporosis is one of the most common bone diseases in women. The aim of the present study was to predict the diagnostic function modules from a differential co-expression gene network in order to enhance the current understanding of the biological processes and to promote the early prevention and intervention of post-menopausal osteoporosis. The diagnostic function modules were extracted from a differential co-expression network by the established protein-protein interaction (PPI) network analysis. First, significant genes were identified from the differential co-expression network, which were regarded as seed genes. Starting from the seed genes, the sub-networks in this disease, referred to as diagnostic function modules, were exhaustively searched and prioritized through a snowball sampling strategy to identify genes to accurately predict clinical outcomes. In addition, crucial function inference was performed for each diagnostic function module. Based on the microarray and PPI data, the differential co-expression network was constructed, which contained 1,607 genes and 4,197 interactions. A total of 110 seed genes were identified, and nine diagnostic modules that accurately distinguished post-menopausal osteoporosis from healthy controls were screened out from these seed genes. The diagnostic modules may be associated with five functional pathways with emphasis on metabolism. A total of nine diagnostic functional modules screened in the present study may be considered as potential targets for predicting the clinical outcomes of post-menopausal osteoporosis, and may contribute to the early diagnosis and therapy of osteoporosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Systemic tracking of diagnostic function modules for post-menopausal osteoporosis in a differential co-expression network view

Wang

Luo³

2018

Exp Ther Med

View full text Add to dashboard Cite

show abstract

Integrating transcriptome-wide association study and mRNA expression profiling identifies novel genes associated with bone mineral density

Huang

Liang

et al. 2019

Osteoporos Int

View full text Add to dashboard Cite

Serum carcinoembryonic antigen-related cell adhesion molecule 1 level in postmenopausal women: correlation with β-catenin and bone mineral density

Abstract: This study provides evidence that decreased serum CEACAM1 levels are related to low BMD in postmenopausal women, and that serum CEACAM1 levels correlated positively to β-catenin. It suggests that CEACAM1 might influence the canonical Wnt/β-catenin pathway to modulate bone metabolism.

Cited by 2 publications

References 38 publications

Systemic tracking of diagnostic function modules for post-menopausal osteoporosis in a differential co-expression network view

Systemic tracking of diagnostic function modules for post-menopausal osteoporosis in a differential co-expression network view

Integrating transcriptome-wide association study and mRNA expression profiling identifies novel genes associated with bone mineral density

Contact Info

Product

Resources

About