Serum carcinoembryonic antigen levels and proliferating cell nuclear antigen labeling index for patients with colorectal carcinoma: Correlation with tumor progression and survival

Nakamura, Takeshi; Tabuchi, Yoshiaki; Nakae, Shiro; Ohno, Masakazu; Saitoh, Yoichi

doi:10.1002/(sici)1097-0142(19960415)77:8+<1741::aid-cncr25>3.0.co;2-x

Cited by 14 publications

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“…27 The limitations of this study include the relatively brief follow-up period and the small sample size. Further research is required to rectify these problems.…”

Section: Discussionmentioning

confidence: 98%

Prognostic value of preoperative CEA, CA 19-9, CA 72-4, and AFP levels in gastric cancer

et al. 2008

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“…27 The limitations of this study include the relatively brief follow-up period and the small sample size. Further research is required to rectify these problems.…”

Section: Discussionmentioning

confidence: 98%

Prognostic value of preoperative CEA, CA 19-9, CA 72-4, and AFP levels in gastric cancer

et al. 2008

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“…In colon cancer, CEA modulates intercellular adhesion and functions as a promoter of cellular aggregation [20,21], suggesting that CEA has an important role as a facilitator of tumor invasion and metastasis. Nakamura et al [22] reported that seven clinicopathological variables, including undifferentiated tumors, deep tumor invasion, lymphatic and venous invasion, node metastasis, liver metastasis, and advanced stages were significantly greater for patients with a positive CEA (>5 ng/ml) than for patients with a negative CEA (<5 ng/ml). We found that the serum CEA level was significantly associated with tumor size, T category, N category, number of lymph nodes retrieved, and operative method, but no association was detected between the serum CEA level and tumor differentiation or lymphatic or neural invasion.…”

Section: Discussionmentioning

confidence: 99%

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Huh

Kim

et al. 2010

Journal of Surgical Oncology

110

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Objective: We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colon cancer. Methods: We reviewed 474 patients who underwent potentially curative resection for nonmetastatic colon cancer. Patients were categorized into two groups according to the preoperative serum CEA level: low CEA (<5 ng/ml) and high CEA ( 5 ng/ml) groups. Results: During the median 45-month follow-up period, the 5-year overall and disease-free survival rates for patients with a low CEA level were 81.7% and 82.4%, respectively, which were significantly higher than the rates for those with a high CEA level (69.9%; P ¼ 0.011 and 70.6%; P ¼ 0.002, respectively). A multivariate analysis revealed that a preoperative serum CEA level was a significant independent prognostic factor for both overall survival (P ¼ 0.021) and disease-free survival (P ¼ 0.026). Both the overall and disease-free survival rates in patients with stage II tumors differed significantly between the low and high CEA groups, whereas the rates did not different between those with stage I and III tumors. Conclusions: Preoperative serum CEA is a reliable predictor of recurrence and survival after curative surgery in patients with colon cancer, particularly in those classified as having stage II disease.

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“…Several small-scale retrospective studies have demonstrated that CRC patients with high preoperative levels of CEA have a worse prognosis than those with low levels (8,30) . Preoperative CEA thus has the potential to supply prognostic data independent of the traditional staging systems in patients with CRC (6,7,8,19,21,25,28) . CEA can also be detected and quantitatively measured in colorectal tumor tissue and normal mucosa (1,2,3,4,5,9,17,12,13,18,26) , but its role in the management of colorectal cancer remains controversial (4,11,20) .…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of carcinoembryonic antigen distribution in tumor tissue of colorectal carcinoma

Nazato

Matos

Waisberg

et al. 2009

Arq. Gastroenterol.

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-Context -Carcinoembryonic antigen (CEA) can be detected in colorectal tumor tissue but its role in the survival of patients remains controversial. Objective -To characterize the expression of tissue CEA using immunohistochemical staining in colorectal tumors and to analyze the relationship between this finding and preoperative plasmatic level of CEA, morphologic features and survival of patients operated with curative intent for colorectal carcinoma. Method -Forty-seven patients were included in the study: 18 (38.3%) males and 29 (61.7%) females, with a mean age of 67.8 ± 9.7 years (37 to 84 years). Immediately before laparotomy, pre-operative serum levels of CEA were obtained where normal levels were considered ≤2.5 ng/mL for non-smokers, and ≤5.0 ng/mL for smokers. CEA immunohistochemical studies were carried out using anti-human CEA monoclonal mouse antibody. The expression of immunostaining for each neoplasia was classified according to the pattern of CEA tissular distribution into apical or cytoplasmic. The variables considered for the statistical analysis were plasmatic preoperative CEA level, location of the lesion within the large intestine, lesion diameter, lymph node involvement, Duke's classification, vein invasion, grade of cellular differentiation, survival and pattern of CEA tissular distribution. The statistical models utilized were Spearman's correlation and the Mann-Whitney, Kruskal-Wallis and Student t tests. Patients' survival was analyzed using the KaplanMeier method. Results -The mean preoperative CEA value was 15.4 ± 5.5 ng/mL (0.2 to 92.1 ng/mL). The neoplasm was located in the colon in 29 (61.7%) and in the rectum in 18 (38.3%) patients. Eight (17.0%) patients were classified as Duke's stage A, 22 (46.8%) as stage B and 17 (36.2%) as stage C. On immunohistochemical studies, the pattern of CEA tissular distribution was apical in 33 (70.2%) patients and cytoplasmic in 14 (29.8%) patients. Patients with apical patterns presented a mean sera CEA level of 15.5 ± 6.5 ng/mL while those with cytoplasmic pattern attained a mean sera CEA level of 15.1 ± 7.3 ng/mL, with no significant difference between these values (P = 0.35). Apical distribution of CEA occurred in 6 (12.8%) Duke A, 18 (38.2%) Duke B and 9 (12.2%) Duke C patients, while cytoplasmic CEA tissular distribution was observed in 2 (4.2%) Duke A, 3 (6.4%) Duke B and 9 (19.1%) Duke C patients. Patients with Duke B neoplasms presented significantly more apical CEA tissular distribution patterns (P = 0.049) than subjects with cytoplasmic CEA tissular patterns. The apical CEA tissular distribution pattern in neoplasms was significantly more frequent in neoplasms with no lymph node compromise compared to the cytoplasmic pattern (P = 0.50). However, no significant differences were seen between apical and cytoplasmic CEA tissular distribution patterns in terms of colon or rectal site (P = 0.21), lesion diameter across greatest axis (P = 0.19), vein invasion (P = 0.13) or degree of cellular differentiation (P = 0.19). Of the 47 patients...

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Serum carcinoembryonic antigen levels and proliferating cell nuclear antigen labeling index for patients with colorectal carcinoma: Correlation with tumor progression and survival

Cited by 14 publications

References 0 publications

Prognostic value of preoperative CEA, CA 19-9, CA 72-4, and AFP levels in gastric cancer

Prognostic value of preoperative CEA, CA 19-9, CA 72-4, and AFP levels in gastric cancer

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Prognostic value of carcinoembryonic antigen distribution in tumor tissue of colorectal carcinoma

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