Serum Carbohydrate Antigen 125 Levels in Nonischemic Dilated Cardiomyopathy: A Useful Biomarker for Prognosis and Functional Mitral Regurgitation

Abstract

The authors investigated the prognostic relevance of serum carbohydrate antigen 125 (CA125) levels in nonischemic dilated cardiomyopathy (NICMP) and assessed whether increased levels relate to the degree of functional mitral regurgitation (FMR). Seventy-seven patients with NICMP were enrolled and followed-up for 10 ± 2 months in this prospective study. Receiver-operating characteristic analysis established a cutoff CA125 value of 25 U/mL for predicting mortality. Patients were divided into two groups according to their CA125 levels (CA125 <25 U/mL [n=58] and CA125 ≥ 25 U/mL [n=19]). Patients with high CA125 values had statistically worse functional status, higher B-type natriuretic peptide (BNP) levels, higher left ventricular volumes, lower ejection fraction, higher E/Em ratio, higher pulmonary artery systolic pressure, and more severe FMR. On the multivariate analysis, serum CA125 (P=.002) and severe FMR (P=.04) were identified as the independent predictors of mortality. Serum CA125 levels also correlated with BNP levels and FMR severity (P<.001). Serum CA125 is a powerful prognostic biomarker that is associated with the severity of heart failure, serum BNP levels and several echocardiographic parameters including left ventricular volumes, systolic and diastolic functions, pulmonary artery pressure, and the degree of FMR. Serum CA125 was also shown as an independent predictor of mortality during 10 ± 2 months of follow-up.

Reassessment of genes associated with dilated and hypertrophic cardiomyopathy in a Chinese Han population

“…MUC16 is also known as CA125, whose protein product is the tumor marker carbohydrate antigen 125. Serum carbohydrate antigen 125 level is reportedly correlated with DCM prognosis and clinical severity [17,18] . FBN1 was mostly reported as a causal gene of Marfan syndrome [19,20] while in this study, we found the association of FBN1 and DCM, which will be reported in another work of our team.…”

Postoperative transient elevation of serum cancer antigen 125 in non-small cell lung cancer patients

“…By careful examination of all clinical features with transient CA-125 elevation, we found that pro-BNP levels after surgery were strongly correlated with transient elevation of serum CA-125 in NSCLC patients (Figure 1B) p=0.00035 (Table 2). Several previous studies have shown that both CA-125 and pro-BNP was significantly related with heart function in heart disease patients, and the CA-125 levels were positively correlated with pro-BNP in heart disease patients [21][22][23] . Pro-BNP is a quantitative biomarker of myocardial function.…”

Association between CA-125, ESR, and high-sensitive C-reactive protein and cardiac function in hemodialysis patients

“…The authors concluded that CA-125 level is significantly associated with LV cardiac failure in hemodialysis patients. Several studies have implicated the role of CA-125 level in congestive heart failure (CHF) (17) as well as nonischemic dilated cardiomyopathy (18). In a study on 77 male patients with CHF, it was shown that CA-125 levels were associated with CHF severity (determined by NYHA classification) and fluid overload defined by pulmonary congestion and ankle edema (19).…”