Serum Calcium, Phosphorus and Magnesium Levels in Pregnant and Non‐pregnant Nigerians

Olatunbosun, D. A.; Adeniyi, F. A. A.; Adadevoh, B. Kwaku

doi:10.1111/j.1471-0528.1975.tb00688.x

Cited by 24 publications

(11 citation statements)

References 16 publications

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“…Also as serum potassium is "entirely exchangeable" between the mother and fetus, there must be enough, so that both parties do not suffer hypokalemia. Similar third-trimester values have been reported for Australian women [6] and women in Western Nigeria [5,7]. Serum potassium levels were also found to decrease with increasing parity (Y= -0.72; p<0.05).…”

Section: Discussionsupporting

confidence: 83%

Changes in serum potassium levels during pregnancy in Nigerian women.

Onyeneke

Alumanah

1990

J. Clin. Biochem. Nutr.

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SummaryIn our study of potassium levels in normal pregnant Nigerian women the mean serum potassium concentration was 5 .80+ 1.50 mEq/liter (pooled data of all pregnant women irrespective of gestational age). This level decreased with maternal age and parity and increased progressively with gestational age. The value recorded in the first trimester was 4.50±0.35 mEq/liter, which increased to 5.85±0.80 mEq/liter in the second trimester and to 6.00+0.60 mEq/liter in the third trimester.Apart from other factors that affect serum potassium levels during pregnancy, the social status of the pregnant women was also found to influence the values, rising from 5.50±0.10 mEq/liter in the case of farmers to 6.00±0.20 mEq/liter in the case of civil servants . The nutritional implications of this study with respect to proper fetal development is discussed.

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Section: Discussionsupporting

confidence: 83%

Changes in serum potassium levels during pregnancy in Nigerian women.

Onyeneke

Alumanah

1990

J. Clin. Biochem. Nutr.

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“…17 As during pregnancy, there is a hemodilution and with the expansion of extracellular fluid volume, there is a dilution of the cation and also lead to normal hypercalciuria of pregnancy consequent to increased glomerular filtration. 18 Our study concluded that the serum calcium in normal pregnant women was reduced when compared with healthy nonpregnant women with the statistically highly significant difference (p < 0.001) as supported by Olatunbosun et al 19 who earlier in their study observed a highly significant reduction in serum concentration of calcium during the third trimester of normal pregnancy. According to one study, in normal pregnancy hemodilution effect of estrogen and increased demand of fetus decreases the serum magnesium level.…”

Section: Discussionsupporting

confidence: 65%

Comparative Study of Serum Calcium and Magnesium in Pre-eclamptic Pregnancies in Third Trimester and its Comparison with Healthy Normotensive Nonpregnant and Pregnant Women and to Evaluate their role in Pregnancy-induced Hypertension

Varma¹,

Sogani²,

Sarkar³

2015

MGM Journal of Medical Sciences

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Background: Despite numerous studies, the etiology of pre eclampsia has not been fully elucidated. The study of serum calcium and serum magnesium is gaining ground in the patho physiology of hypertension.Objective: A comparative study of serum calcium and serum magnesium in women with preeclamptic pregnancy and its comparison with healthy normotensive nonpregnant women and healthy normotensive pregnant women in third trimester. Materials and methods:Serum calcium and serum magnesium were measured in 52 women with preeclampsia in their trimester of pregnancy as patients group, and in 73 healthy normotensive nonpregnant women and 65 healthy normotensive pregnant women as control groups with similar maternal and gestational ages. Preeclamptic group was further divided into two subgroups mild (n = 36) and severe preeclampsia (n = 16). This is the casecontrol hospital based study carried in the Department of Biochemistry, MGM Medical College and associated MY Hospital, Indore, Madhya Pradesh.Results: There were no significant differences among the three groups in age and body mass index (BMI) (p > 0.05) but significantly higher differences in gestational age, systolic and diastolic blood pressure was observed (p < 0.001). When com parison of serum calcium and serum magnesium between healthy normotensive nonpregnant women (9.87 ± 0.6 mg/dl, 2.60 ± 0.3 mg/dl) and healthy normotensive pregnant women was done, the levels were lower in the healthy normotensive preg nant women (9.34 ± 0.49 mg/dl, 2.36 ± 0.13 mg/dl) with sta tistically higher significant difference (p < 0.001). Lower mean values of serum calcium and serum magnesium were found in preeclamptic women (8.82 ± 0.93 mg/dl, 1.74 ± 0.24 mg/dl) than those of healthy normotensive nonpregnant women (9.87 ± 0.6 mg/dl, 2.60 ± 0.3 mg/dl) and healthy normotensive pregnant women (9.34 ± 0.49 mg/dl, 2.36 ± 0.13 mg/dl) in third trimester with statistically higher significant differences (p < 0.001). As compare to mild preeclamptic pregnant women (9.07 ± 0.8 mg/ dl, 1.77 ± 0.24 mg/dl), the levels of serum calcium and serum magnesium in severe preeclamptic pregnant women (8.25 ± 0.97 mg/dl 1.65 ± 0.24 mg/dl) was lower and the difference was significantly higher (p < 0.001). Conclusion:These findings support the hypothesis that hypo calcemia and hypomagnesemia are possible etiologies of preeclampsia and levels of calcium may be more important than magnesium.

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“…1 However, there are contrasting views on the effects of gestational age and the interpretation of serum Ca levels as other studies have concluded that Ca homeostasis is considerably changed during pregnancy and non-pregnant reference limits are often invalid and the upper normal limit for total serum Ca during pregnancy is 2.37 mmol/L. 30,40,41,44 …”

Section: Discussionmentioning

confidence: 95%

The Role of Calcium Correction during Normal Pregnancy at Third Trimester in Mosul

Hanna

2009

OMJ

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In healthy pregnant women even during limited sun exposure time in winter, there was no need for calcium supplementation in spite of the continuous and progressive reduction of serum measured total calcium during the second and third trimesters due to dilutional hypoalbuminemia. During pregnancy, measured calcium is parallel to both corrected and ionized calcium and since there was no significant difference between measured and corrected calcium, therefore, measured calcium is a useful test in assessing calcium status and suggests the need to establish a reference range for pregnant women.

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Serum Calcium, Phosphorus and Magnesium Levels in Pregnant and Non‐pregnant Nigerians

Cited by 24 publications

References 16 publications

Changes in serum potassium levels during pregnancy in Nigerian women.

Changes in serum potassium levels during pregnancy in Nigerian women.

Comparative Study of Serum Calcium and Magnesium in Pre-eclamptic Pregnancies in Third Trimester and its Comparison with Healthy Normotensive Nonpregnant and Pregnant Women and to Evaluate their role in Pregnancy-induced Hypertension

The Role of Calcium Correction during Normal Pregnancy at Third Trimester in Mosul

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