Serum Calcium and Magnesium Levels in Schizophrenia

Alexander, Paul

doi:10.1001/archpsyc.1979.01780120102012

Cited by 36 publications

(3 citation statements)

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“…Intake of neuroleptics is known to lower plasma Mg regardless of their chemical structure [5], The same trend was noticed in this study. Five patients free of medica tion on admission showed a decrease in plasma Mg after 7 days of treatment with neuroleptics from 0.73 (SD = 0.10) to 0.63 (SD = 0.16) mmol/1, (n.s.…”

Section: Resultssupporting

confidence: 89%

Magnesium, Schizophrenia and Manic-Depressive Disease

Kirov¹,

Tsachev²

1990

Neuropsychobiology

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Plasma magnesium (Mg) levels were estimated in 15 schizophrenic, 10 depressed, 6 manic and 6 pre-senile Alzheimer’s disease patients and compared with those in 303 healthy controls. The schizophrenic and depressed patients showed lower levels, but the levels were normal in the other two groups. Mg levels increased on achieving clinical remission in the schizophrenic patients. A hypothesis is proposed according to which the high level of stress found in severely ill psychiatric patients can lead to marginal Mg deficiency in susceptible individuals. This could exacerbate symptoms such as anxiety, fear, hallucinations, weakness and somatic complaints.

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Section: Resultssupporting

confidence: 89%

Magnesium, Schizophrenia and Manic-Depressive Disease

Kirov¹,

Tsachev²

1990

Neuropsychobiology

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“…2 As well, the relative concentration of one metal may influence the concentration and action of another metal, e.g. zinc and copper, 13 ' 14 and magnesium and calcium, 15 are known to interact metabolically. Hence, the significance of a small number of metal concentrations in the pathogenesis of a given disorder is difficult to interpret.…”

mentioning

confidence: 99%

Regional Metal Concentrations in Parkinson's Disease, Other Chronic Neurological Diseases, and Control Brains

Uitti

Rajput²,

Rozdilsky³

et al. 1989

Can. j. neurol. sci.

121

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ABSTRACT:Metal deficiency or toxicity states have been recognized as a cause of several neurological disorders and are suspected in others. We analyzed four brain regions (frontal cortex, caudate nucleus, substantia nigra, and cerebellum) in 36 human brains for concentrations of 24 metals (Ag, Al, As, B, Be, Ca, Cd, Co, Cr, Cu, Fe, K, Pb, Mg, Mn, Mo, Na, Ni, P, Se, Ti, V, W, Zn). Regional metal concentrations, measured using atomic absorption and atomic emission spectroscopy, were compared between 9 Parkinson's disease (PD) brains, 15 brains from patients with other chronic neurological diseases, and 12 control brains. No significant metal concentration differences were noted between brains from PD and other chronic neurologic disease. However, parkinsonian brains (PD and parkinsonism secondary to neurofibrillary tangle disease) showed lower concentrations of magnesium in the caudate nucleus and copper in the substantia nigra than control brains. These findings may represent an etiologically important clue to parkinsonism. RESUME: Concentrations regionales de metaux dans le cerveau de patients souffrant de la maladie de parkinson, d'autres maladies neurologiques chroniques et de sujets controles Un deficit ou une surcharge en metaux est reconnue comme etant la cause de plusieurs affections neurologiques et Ton soupconne ce mecanisme d'etre a l'origine de certains autres desordres neurologiques. Nous avons analyse la concentration de 24 metaux (Ag, Al, As, B, Be, Ca, Cd, Co, Cr, Cu, Fe, K, Pb, Mg, Mn, Mo, Na, Ni, P, Se, Ti, V, W, Zn) dans quatre regions du cerveau (cortex frontal, noyau caude\ substance noire et cervelet) de 36 sujets. Nous avons compare les concentrations regionales de metaux dans le cerveau de 9 patients atteints de la maladie de Parkinson, 15 patients presentant d'autres maladies neurologiques chroniques et 12 sujets controles. La determination des concentrations de metaux a ete effectuee par spectroscopic d'absorption atomique et par spectroscopie d'emission atomique. Nous n'avons pas trouve de difference significative entre les concentrations de ces metaux dans les cerveaux des patients atteints de la maladie de Parkinson et ceux des patients atteints d'autres maladies neurologiques chroniques. Cependant, les cerveaux des parkinsoniens (maladie de Parkinson et parkinsonisme secondaire a la maladie des amas neurofibrillaires) contenaient des concentrations plus faibles de magnesium au niveau du noyau caude et de cuivre au niveau de la substance noire que les cerveaux des sujets controles. Ces observations peuvent constituer un indice important quant a l'etiologie du parkinsonisme.

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“…& Lovirr, R. (1984) An examination of patients' understand ing of information from health care professionals. Hospital and Community Psychiatry,35,619â€"620. Calcium and Extrapyramidal symptoms SIR: It has been suggested that serum calcium ion levels may predict both the onset and occurrence of extrapyramidal symptoms (EPS) (Alexander et al, 1979;El-Defrawi & Craig, 1984) and more recently Fernando & Manchanda (Journal, May 1988, 152, 722â€"723)reported on their successful treatment of EPS with calcium in two patients. We wish to report the findings of an investigation into the relationship between severity of EPS and serum calcium levels in a population of patients on neurobeptic medication.…”

Section: Supportive Psychot1serapymentioning

confidence: 99%