Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study

Rooney, Mary R.; Pankow, James S.; Sibley, Shalamar D.; Selvin, Elizabeth; Reis, Jared P.; Michos, Erin D.; Lutsey, Pamela L.

doi:10.3945/ajcn.115.130021

Cited by 56 publications

(52 citation statements)

References 41 publications

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“…Sing et al followed up 6096 participants for 59,130.9 persons-years while measuring serum total calcium and ACCA and found an association between elevated serum calcium concentration and incident diabetes 23 . Rooney et al also obtained the same result by following 1516 participants for an average of 8.8 years 24 . There are three possible mechanisms to explain this result.…”

Section: Discussionmentioning

confidence: 57%

“…There are three possible mechanisms to explain this result. First, serum calcium is associated with insulin resistance in adipocytes and skeletal muscle as a result of a decreased number of glucose transporters 24,25 . Calcium-dependent enzymes and calcium channels are responsible for glucose uptake after insulin stimulates muscle cells 12,26,27 .…”

Section: Discussionmentioning

confidence: 99%

“…Although we applied ACCA, there are studies that suggest ionized calcium is a better indicator of the serum calcium status 38,39 . Second, this would have been a more complete study if we had taken the level of PTH into account, since previous studies have shown a strong relationship between PTH level and MetS components 17,24 . Third, because serum calcium and phosphorous levels are closely related, we should also take the phosphorus level into consideration [28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

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Association between Serum Calcium and Risk of Cardiometabolic Disease among Community-dwelling Adults in Taiwan

Chou

Fang

Chen

et al. 2020

Sci Rep

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Serum calcium, although only comprising 1% of total body calcium, is involved in intracellular signal pathways, vascular dilatation/constriction, and muscle contraction, which are crucial for insulin secretion, cholesterol catabolism, and blood pressure regulation. As far as we know, research on the relationship between serum calcium level and metabolic syndrome (MetS), diabetes, and hypertension in one longitudinal study is rare. Owing to the crucial role of serum calcium in human cardiometabolic physiology and lack of related study so far, this study aims to describe the relationship between serum calcium level and the incidence of MetS, diabetes, and hypertension. During the period 2010-2016, there are two parts to our study: cross-sectional analysis and longitudinal analysis. Logistic regression was applied for cross-sectional analysis of the association between serum calcium level or albumincorrected calcium (ACCA) and the prevalence of MetS, diabetes, or hypertension. Receiver operating characteristic (ROC) curve analysis was used for calculating of optimal cut-off value of serum calcium and ACCA. Cox proportional regression for development of MetS, diabetes, and hypertension according to different cut-off values of serum calcium level and ACCA were conducted. At baseline, there were 27,364 participants in our study. Serum calcium level had positive association with diabetes in the total population, male, and female. ACCA level had positive association with diabetes in the total population, male, and female. In unadjusted and multivariate Cox proportional hazard models, serum calcium level was associated with increased risk of incident MetS in the total population and male. ACCA was associated with increased risk of incident MetS in the total population and male. ACCA was associated with increased risk of incident diabetes in the total population and male participants. This study describes the relationship between serum calcium level and the incidence of MetS, diabetes, and hypertension. Higher serum calcium level is associated with increased risk of MetS, diabetes, and hypertension.Metabolic syndrome (MetS), diabetes mellitus, and hypertension are three major health challenges in industrialized countries worldwide. According to the estimation of the International Diabetes Federation (IDF), the prevalence of MetS around the world is 25% 1 . The estimated number of people with diabetes in 2030 will be 366 million, and the number of adults with hypertension in 2025 is predicted to be 1. 56 billion 2 . Serum calcium, although only open Scientific RepoRtS | (2020) 10:3192 | https://doi.org/10.1038/s41598-020-60209-wwww.nature.com/scientificreports www.nature.com/scientificreports/ comprising 1% of total body calcium, is involved in intracellular signal pathways, vascular dilatation/constriction, and muscle contraction 3 . These functions are crucial for insulin secretion, cholesterol catabolism, and blood pressure regulation, which are important etiologies of MetS, diabetes, and hypertension. Hypertension occu...

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between Serum Calcium and Risk of Cardiometabolic Disease among Community-dwelling Adults in Taiwan

Chou

Fang

Chen

et al. 2020

Sci Rep

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“…Several studies have found associations between high levels of calcium in the blood and risk of developing T2DM. Such studies include the PREDIMED study [74], the Atherosclerosis Risk in Communities (ARIC) study [75], the Insulin Resistance Atherosclerosis study [76] and the Tromsø study [77]. In addition, elevated total plasma calcium levels are also found in individuals with T2DM compared to healthy controls; no difference was observed between males and females and the duration of diabetes had no influence on calcium levels [78].…”

Section: Changes In Metal Ion Homeostasismentioning

confidence: 99%

Coagulatory Defects in Type-1 and Type-2 Diabetes

Sobczak

Stewart

2019

IJMS

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Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

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“…However, obesity continues to be a serious health issue in the United States, and preventive efforts have not been fruitful. In addition to obesity, other risk factors, such as the one suggested by Rooney et al (1) in this issue of the Journal, imply opportunities for the development of new prevention strategies. In this study, the investigators evaluated serum calcium as a potential risk factor for incident diabetes in a large biracial prospective cohort from the ARIC (Atherosclerosis Risk in Communities) study.…”

mentioning

confidence: 99%