Serum calcium, alkaline phosphotase and hemoglobin as risk factors for bone metastases in bladder cancer

Huang, Ping; Lan, Min; Peng, Ai-Fen; Yu, Qing-Fu; Chen, Wenzhao; Liu, Zhi‐Li; Liu, Jiaming; Huang, Shan-Hu

doi:10.1371/journal.pone.0183835

Cited by 46 publications

(39 citation statements)

References 17 publications

(17 reference statements)

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“…In other words, pre-treatment ALP values may be a useful biomarker in the choice of treatment, even in early metastatic PC. The prognostic value of ALP has been shown in various solid malignancies with bone metastasis [11][12][13]. However, while there is a biological rationale underlying this association, the exact mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of alkaline phosphatase in hormone-sensitive prostate cancer: a systematic review and meta-analysis

et al. 2019

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Purpose To assess the prognostic value of alkaline phosphatase in patients with hormone-sensitive prostate cancer. Methods A systematic review and meta-analysis was performed using the PUBMED, Web of Science, Cochrane Library, and Scopus in April 2019 according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. Studies were deemed eligible if they compared hormone-sensitive prostate cancer patients with high vs. low alkaline phosphatase to determine its predictive value for overall survival, cancer-specific survival, and progression-free survival. We performed a formal meta-analysis of these outcomes. Results 42 articles with 7938 patients were included in the systematic review and 28 studies with 5849 patients for the qualitative assessment. High alkaline phosphatase was associated with worse overall survival (pooled HR 1.72; 95% CI 1.37−2.14) and progression-free survival (pooled HR 1.30; 95% CI 1.10−1.54). In subgroup analyses of patients with "high-volume" and "low-volume", alkaline phosphatase was associated with the overall survival (pooled HR 1.41; 95% CI 1.21−1.64 and pooled HR 1.64; 95% CI, 1.06−2.52, respectively). Conclusions In this meta-analysis, elevated serum levels of alkaline phosphatase were associated with an increased risk of overall mortality and disease progression in patients with hormone-sensitive prostate cancer. In contrast, those were not associated with an increased risk of cancer-specific mortality. Alkaline phosphatase was independently associated with overall survival in both patients with "high-volume" and "low-volume" hormone-sensitive prostate cancer. Alkaline phosphatase may be useful for being integrated into prognostic tools that help guide treatment strategy, thereby facilitating the shared decision making process.

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Section: Discussionmentioning

confidence: 99%

“…ALP is a glycoprotein derived from bones, liver, kidney, or placenta that has been shown to be elevated and of prognostic value for various malignancies [10][11][12][13]. In PC, ALP has been shown to be of prognostic value in CRPCreflecting disease outcome, independent of therapy [14].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of alkaline phosphatase in hormone-sensitive prostate cancer: a systematic review and meta-analysis

et al. 2019

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“…The high ALP level has been reported related to the poor survival in colorectal cancer 71. The elevation of ALP is also an independent risk factor in the bone metastasis of gastric cancer and bladder cancer 72,73. However, the underlying mechanisms of ALP in patients with PCa remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of serum alkaline phosphatase in the survival of prostate cancer: evidence from a meta-analysis

Li¹,

Lv²,

Hao³

et al. 2018

CMAR

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BackgroundMany studies have evaluated the relationship between alkaline phosphatase (ALP) and the prognosis for prostate cancer (PCa). But they have not reached a widespread consensus yet. Therefore, we completed a meta-analysis to ascertain the significance of ALP and the prognosis for PCa.MethodsA literature search was performed in the PubMed, Embase, and Web of Science databases. HRs concerning overall survival (OS), progression-free survival (PFS), and cancer-specific survival (CSS) were extracted to evaluate the impacts of ALP on the prognosis for PCa. Subgroup analyses were conducted on different study types, regions, sample sizes, and cutoff values. Sensitivity analysis was performed by removing one study in sequence.ResultsA total of 63 studies from 54 articles with 16,135 patients were included in this meta-analysis. The pooled results indicated that high baseline ALP was associated with obviously poor OS (HR=1.74, 95% CI: 1.47–2.06) and PFS (HR=1.60, 95% CI: 1.13–2.26) in patients with PCa. The pooled HR for bone-specific ALP and OS was 1.76 (95% CI: 1.45–2.15). However, no association between ALP and CSS (HR=1.002, 95% CI: 0.998–1.005) was found for PCa. The results of subgroup analyses were all in accordance with the main findings. Sensitivity analysis suggested that no single study could affect the stability of the results.ConclusionHigh serum ALP is significantly associated with poor OS and PFS except for CSS in PCa. ALP is an efficient and convenient biomarker for PCa prognosis.

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“…18 What is more, tumor markers can be used to predict cancer metastasis, which is of great significance. For, example, Huang et al 19 observed that ALP and HB were risk factors for bone metastases in patients with bladder cancer. And CA-125 might play an important role in tumor metastasis, and could be thought as an independent risk factor for bone metastases in patients with lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer

Chen

Liu

et al. 2019

Cancer Medicine

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Lung cancer is prone to metastasis to various organs. Although intraocular metastasis (IOM) occurs at a later stage than metastasis to other organs, it often adversely affects the quality of life and suggests a poor prognosis. In this study, we selected 1608 patients with lung cancer who had metastasis to at least one site and explored clinical differences between those with IOM and non‐IOM (NIOM). An independent t test and chi‐squared test were used to analyze the clinical features of the patients. The statistically significant parameters were analyzed by binary logistic regression to determine the risk factors for IOM. A receiver operating characteristic curve was constructed to assess their diagnostic value in IOM. The results showed that no significant differences were noted in age, gender, and pathological type between the IOM and NIOM groups. However, the IOM group had higher levels of alpha‐fetoprotein, carcinoembryonic antigen, cancer antigen (CA)‐125, CA‐153, cytokeratin fragment 19 (CYFRA 21‐1), and total prostate‐specific antigen, compared with the NIOM group. Binary logistic regression indicated that CA‐153 and CYFRA 21‐1 were risk factors for IOM in patients with MLC (P < 0.05). Area under the curve of CA‐153, CYFRA 21‐1 and their combination were 0.791, 0.860, and 0.872 respectively. The cutoff values for CA‐153 and CYFRA 21‐1 were 22.2 U/mL and 6.785 ng/mL. In conclusion, both CA‐153 and CYFRA 21‐1 were independent risk factors for IOM in patients with metastatic lung cancer (MLC), whereas the combination of CA‐153 and CYFRA 21‐1 assessment yields the most value in the detection of IOM in patients with MLC.

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Serum calcium, alkaline phosphotase and hemoglobin as risk factors for bone metastases in bladder cancer

Cited by 46 publications

References 17 publications

Prognostic value of alkaline phosphatase in hormone-sensitive prostate cancer: a systematic review and meta-analysis

Prognostic value of alkaline phosphatase in hormone-sensitive prostate cancer: a systematic review and meta-analysis

Prognostic value of serum alkaline phosphatase in the survival of prostate cancer: evidence from a meta-analysis

Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer

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