Serum Calcitonin Gene-Related Peptide and Receptor Protein Levels in Patients With Fibromyalgia Syndrome: A Cross-Sectional Study

Abstract

Objectives This study aims to compare the serum calcitonin gene-related peptide (CGRP) and CGRP receptor protein levels between patients with fibromyalgia syndrome (FM) and healthy control subjects. Patients and methods The study included 88 patients (7 males, 81 females; mean age 44.5±9.1 years; range, 20 to 72 years) newly-diagnosed with FM according to the 2010 American College of Rheumatology criteria and 88 healthy volunteers (6 males, 82 females; mean age 43.0±6.1 years; range, 20 to 57 years). Venous blood samples were collected from both groups for the measurement of the levels of serum CGRP and CGRP receptor proteins (receptor component protein [RCP], receptor activity modifying protein 1 [RAMP 1] and calcitonin receptor-like receptor [CLR]). Results A comparison of the serum CGRP, CLR and RCP levels of the FM and control groups revealed a statistically significant difference (p=0.001, p=0.005, p=0.001, respectively). The difference between the groups in respect of the serum RAMP 1 levels was not statistically significant (p=0.107). Conclusion The serum CGRP, CLR and RCP levels were found to be higher in the FM patients, but no difference was determined between the FM patients and the healthy control group in respect of the RAMP 1 level. These results can be of guidance for further clinical studies of the etiopathogenesis and treatment of FM.

Fragile X Mental Retardation Protein (FMRP) expression in human nociceptor axons of the spinal dorsal horn— Implications for RNA targeting and localized translation

“…FMRP puncta colocalized with CGRP+ loci in the spinal branches of primary nociceptors in female but not male donor spinal cord. Maladaptive changes in CGRP signaling are emerging as a feature of many chronic pain phenotypes specifically in females (Avona et al, 2019, 2021; Casale et al, 2021; Iyengar et al, 2017; KORUCU et al, 2020; Paige et al, 2022; Siracusa et al, 2021; Sluka & Clauw, 2016; Tavares-Ferreira, Ray, et al, 2022). In female rodents, spinal CGRP signaling plays an important role in multiple chronic pain models by regulating excitatory/inhibitory balance in intrinsic spinal cord neurons (Paige et al, 2022).…”

“…FMRP puncta colocalized with CGRP+ loci in the spinal branches of primary nociceptors in female but not male donor spinal cord. Maladaptive changes in CGRP signaling are emerging as a feature of many chronic pain phenotypes specifically in females (Avona et al, 2019(Avona et al, , 2021Casale et al, 2021;Iyengar et al, 2017;KORUCU et al, 2020;Paige et al, 2022;Siracusa et al, 2021;Sluka & Clauw, 2016;.…”

Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome

“…Some chemokines, cytokines and neuromodulators are known to function during postsynaptic and presynaptic processing of a peripheral nociceptive stimulus in the CNS (2). It has been suggested that hyperalgesia and allodynia develop due to increases or inhibition loss in membrane excitability and synaptic activity through reductions or increases in the inhibitor and excitatory neurotransmitters (3)(4)(5)(6).…”

The Effect of Non-pharmacological Combine Treatment Methods on Serum Beta-Endorphin Level, Pain, Depression, Sleep Quality and Functional Status in Patients with Fibromyalgia

“…Fibromiyalji Sendromu (FMS) yaygın ağrı ile karakterize kronik bir kas iskelet sistemi hastalığıdır (1). FMS'nin etyopatogenezi henüz net olarak bilinmemekle birlikte genetik, çevresel ve immünolojik faktörlerin, periferik ve santral mekanizmaların rol oynadığı düşünülmektedir (2,3). Daha önce yapılan bazı klinik çalışmalarda hipotalamik-pituiter-adrenal (HPA) aksta meydana gelen bir bozukluğun FMS patogenezinde rol oynayabileceği bildirilmiştir (4,5).…”