Serum CA 19–9 Level is Correlated to the Clinical Characteristics and Chronic Complications of Patients Newly Diagnosed with Type 2 Diabetes Mellitus

Cui, Limei; Lv, Naqiang; Li, Bin; Tao, Jing; Zheng, Xiaoya; Yan, Yunqi; Liu, Cuiping

doi:10.1055/a-0994-9970

Cited by 6 publications

(9 citation statements)

References 34 publications

(47 reference statements)

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“…Retrospective studies have suggested an association between type 2 diabetes mellitus and elevated CEA and CA 19-9. 29,30 Our study has several notable limitations. This study was designed as a retrospective cohort study and has an inherent risk of bias, both known and unknown.…”

Section: Discussionmentioning

confidence: 96%

“…Retrospective studies have suggested an association between type 2 diabetes mellitus and elevated CEA and CA 19‐9. 29 , 30 …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the common etiology of elevation of CA 19‐9 in this setting, including acute biliary pancreatitis, and chronic pancreatitis, were excluded in both of cohorts. Retrospective studies have suggested an association between type 2 diabetes mellitus and elevated CEA and CA 19‐9 29,30 …”

Section: Discussionmentioning

confidence: 99%

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Does acute pancreatitis herald pancreatic ductal adenocarcinoma? A multicenter electronic health research network study

et al. 2022

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Background and Objectives High mortality in pancreas ductal adenocarcinoma (PDAC) is related to delayed diagnosis and lack of cost‐effective early detection strategies. Retrospective studies have demonstrated an association between PDAC and acute pancreatitis (AP). Herein, we explore the incidence of PDAC in patients with non‐biliary and non‐alcoholic AP. Methods A population‐based, retrospective cohort study was conducted utilizing TriNetX (Cambridge, MA). Patients ≥40 years with AP (ICD‐10‐CM code: K85) and without biliary AP (K85.1), alcohol‐induced AP (K85.2) or chronic pancreatitis (K86.0, K86.1), were identified. The primary outcome was incidence of PDAC (C25) in patients at defined intervals following AP. We compared the rate of early‐stage diagnosis (stage 1–2) and surgical resection among patients with and without preceding AP. Results The incidence of PDAC ranged from 2.16% (1 year) to 3.43% (5 years). Patients with PDAC and AP in preceding year were more likely to undergo surgical resection relative to those without AP (10.1% vs. 6.3%, risk ratio 1.62: 95% confidence interval, CI 1.47–1.79). Early‐stage diagnosis of PDAC was more frequent in patients with preceding AP; however, difference was insignificant ( p = 0.48; 95% CI 0.64–2.58). Conclusion AP is infrequently associated with PDAC and can precede a diagnosis of PDAC in a minority of patients without another known etiology of pancreatitis. Patients with a recent AP are more likely to undergo surgical resection of PDAC and a trend toward diagnosis at an earlier stage compared to patients with PDAC and without AP. The impact of AP‐related PDAC on survival is unknown.

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Section: Discussionmentioning

confidence: 96%

“…Retrospective studies have suggested an association between type 2 diabetes mellitus and elevated CEA and CA 19‐9. 29 , 30 …”

Section: Discussionmentioning

confidence: 99%

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Does acute pancreatitis herald pancreatic ductal adenocarcinoma? A multicenter electronic health research network study

et al. 2022

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“…[20,21] However, other studies found proteinuria only in 9%, 14%, and 13.5% patients, respectively. [22][23][24] Presently,microalbuminuria is defined as 30 -300mg/24hours (20 -200μg/min) of albumin in the urine is equivalent to 0.46 to 4.6 μmol/24-h. [25] Urine samples should not be taken from patients in diabetic ketoacidosis, hyperosmolar state, or from patients having poor control until adequate glycemic control is established, and should ideally be collected in resting position. A urinary albumin excertion of less than 20μg/min is considered to be normal.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Proteinuria in Newly Diagnosed Diabetic Patients

Rahman¹,

Babar²,

Sebtain³

et al. 2022

PJMHS

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Introduction: Diabetes mellitus is a huge global health issue, affecting more than 350 million people worldwide, and the number might rise to 439 million in 2030. Diabetes Mellitus is associated with many complications. Most of these complications usually develop after many years or even decades of exposure to chronic hyperglycemia. Diabetic Nephropathy is one of the most common and grave complication of diabetes mellitus and is associated with increased morbidity and mortality. Study Design: A cross-sectional study was performed on 285 patients from August 2021 to February 2022 on all newly diabetic patients in Hayatabad Medical Complex, Peshawar. Their 24-hour urine for protein analysis was measured to screen them for proteinuria.After measuring the urine protein level in each patient, the study's total frequency was computed across all the patients who had been diagnosed. Data was recorded into a proforma. Results: The age range in this study was from 15 to 70 years with a mean age of 43.01±6.90 years, mean BMI was 27.67±1.99 Kg/m2, and mean proteinuria levels were 42.38±34.142mg/ dl. Males constituted the majority of the patient-group (62.1%). 34.7% of patients were also hypertensive. Proteinuria was seen in 114 patients (40%). Conclusion: This study has concluded that screening for the complications of diabetic patients is beneficial in the preventive management of the disease. Keywords: Diabetic patients, proteinuria

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“…• Diabetes mellitus is associated with increased CA19-9 values, particularly if metabolic control is poor. 121 Higher cut-off values have also been proposed.…”

Section: Screening (Asymptomatic Subjects)mentioning

confidence: 99%

Challenging biliary strictures: pathophysiological features, differential diagnosis, diagnostic algorithms, and new clinically relevant biomarkers - part 1

Dumonceau

Delhaye

Charette

et al. 2020

Therap Adv Gastroenterol

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It is frequently challenging to make the correct diagnosis in patients with biliary strictures. This is particularly important as errors may have disastrous consequences. Benign-appearing strictures treated with stents may later be revealed to be malignant and unnecessary surgery for benign strictures carries a high morbidity rate. In the first part of the review, the essential information that clinicians need to know about diseases responsible for biliary strictures is presented, with a focus on the most recent data. Then, the characteristics and pitfalls of the methods used to make the diagnosis are summarized. These include serum biomarkers, imaging studies, and endoscopic modalities. As tissue diagnosis is the only 100% specific tool, it is described in detail, including techniques for tissue acquisition and their yields, how to prepare samples, and what to expect from the pathologist. Tricks to increase diagnostic yields are described. Clues are then presented for the differential diagnosis between primary and secondary sclerosing cholangitis, IgG4-related sclerosing cholangitis, cholangiocarcinoma, pancreatic cancer, autoimmune pancreatitis, and less frequent diseases. Finally, algorithms that will help to achieve the correct diagnosis are proposed.

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Serum CA 19–9 Level is Correlated to the Clinical Characteristics and Chronic Complications of Patients Newly Diagnosed with Type 2 Diabetes Mellitus

Cited by 6 publications

References 34 publications

Does acute pancreatitis herald pancreatic ductal adenocarcinoma? A multicenter electronic health research network study

Does acute pancreatitis herald pancreatic ductal adenocarcinoma? A multicenter electronic health research network study

Frequency of Proteinuria in Newly Diagnosed Diabetic Patients

Challenging biliary strictures: pathophysiological features, differential diagnosis, diagnostic algorithms, and new clinically relevant biomarkers - part 1

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