Serum C-reactive protein level after ventral hernia repair with mesh reinforcement can predict infectious complications: a retrospective cohort study

Pochhammer, Julius; Scholtes, Béatrice; Keuler, Jonas; Müssle, Benjamin; Welsch, Thilo; Schäffer, Michael

doi:10.1007/s10029-018-1844-7

Cited by 13 publications

(8 citation statements)

References 30 publications

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“…Thus, it can be tested easily at low cost and with good reliability. In digestive surgery, it can be used as a marker of postoperative complications, specifically infective complications such as anastomosis leakage after colorectal ( 5 , 6 ), pancreatic ( 15 ) or oesophageal ( 16 ), bariatric ( 17 ) surgery or even infectious complications in mesh repair in ventral hernia ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Predictive value of C-reactive protein levels for the early and later detection of postoperative complications after cytoreductive surgery and HIPEC

Roux

David²,

Bardet³

et al. 2022

Front. Oncol.

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SynopsisC-reactive protein (CRP), white blood cells and procalcitonin (PCT) participate in the systemic response to inflammation and increase after postoperative infective complications. Postoperative complications after CRS and HIPEC could be predicted using the CRP cut-off value (169 mg/L at PODs 3-5 and 62 mg/L at PODs 7-10).BackgroundPostoperative elevation of C-reactive protein (CRP) can be used in order to predict the postoperative complications in many indications. Cytoreduction surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with high morbidity.ObjectivesThe aim of the study was to demonstrate the CRP predictive value for the occurrence of complications.MethodsAll patients who had CRS and HIPEC, regardless of the origin of peritoneal metastasis, were included in this retrospective study. Postoperative complications and CRP and white blood cell (WBC) counts were recorded from postoperative day (POD) 1 through 10.ResultsAmong the 127 patients included, 58 (45.7%) had no complications (NCs), 53 (41.7%) had infective complications (ICs), and 16 (12.6%) had non-infective complications (NICs). The IC group had a higher CRP value than the NC group, which was statistically significant from POD7 to POD10 (41.1 versus 107.5 p = 0.023 and 77.8 versus 140 p = 0.047, respectively). A cut-off CRP value was 169 mg/L at PODs 3-5 and 62 mg/L at PODs 7-10. The area under the curve (AUC) at POD5 was 0.56 versus 0.76 at POD7, p=0.007. The sensibility, specificity, positive and negative predictive values of these cut-offs were 55%, 83%, 74% and 67%, respectively. Moreover, 17 patients (32%) with ICs had a CRP value higher than these cut-offs before the diagnosis was made by the medical team.ConclusionThis study suggested that postoperative complications could be predicted using the CRP cut-off value on PODs 3-5 (169 mg/l) and PODs 7-10 (62 mg/l) after CRS and HIPEC.

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Section: Discussionmentioning

confidence: 99%

Predictive value of C-reactive protein levels for the early and later detection of postoperative complications after cytoreductive surgery and HIPEC

Roux

David²,

Bardet³

et al. 2022

Front. Oncol.

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“…We read the publication on "Serum C-reactive protein level after ventral hernia repair with mesh reinforcement can predict infectious complications: a retrospective cohort study" with a great interest [1]. Pochhammer et al concluded that "Our results indicate that postoperative serum CRP allows for early prediction of the postoperative course.…”

Section: Dear Editormentioning

confidence: 98%

“…Pochhammer et al concluded that "Our results indicate that postoperative serum CRP allows for early prediction of the postoperative course. Low CRP during the initial PODs is associated with lower risk of ICs [1]." Indeed, CRP is a non-specific biomarker.…”

Section: Dear Editormentioning

confidence: 99%

Comment on “Serum C-reactive protein level after ventral hernia repair with mesh reinforcement can predict infectious complications: a retrospective cohort study”

Mungmunpuntipantip

Wiwanitkit

2020

Hernia

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“…CRP is a non-specific but high-sensitive indicator of inflammatory response, useful to predict postoperative complications [ 66 , 67 , 68 ]. CRP concentration and fluctuation over time were proved effective as a negative predictive test for anastomotic leakage [ 69 , 70 ], and postoperative infectious complications [ 71 , 72 , 73 , 74 , 75 ]. Besides, procalcitonin may be a valuable marker in the assessment of infections in trauma and ACS patients [ 76 , 77 , 78 , 79 ].…”

Section: Inflammatory Response and Infections In Acute Care Surgery: ...mentioning

confidence: 99%

Antimicrobial Challenge in Acute Care Surgery

Schena¹,

de’Angelis

Carra

et al. 2022

Antibiotics

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The burden of infections in acute care surgery (ACS) is huge. Surgical emergencies alone account for three million admissions per year in the United States (US) with estimated financial costs of USD 28 billion per year. Acute care facilities and ACS patients represent boost sanctuaries for the emergence, development and transmission of infections and multi-resistant organisms. According to the World Health Organization, healthcare-associated infections affected around 4 million cases in Europe and 1.7 million in the US alone in 2011 with 39,000 and 99,000 directly attributable deaths, respectively. In this scenario, antimicrobial resistance arose as a public-health emergency that worsens patients’ morbidity and mortality and increases healthcare costs. The optimal patient care requires the application of comprehensive evidence-based policies and strategies aiming at minimizing the impact of healthcare associated infections and antimicrobial resistance, while optimizing the treatment of intra-abdominal infections. The present review provides a snapshot of two hot topics, such as antimicrobial resistance and systemic inflammatory response, and three milestones of infection management, such as source control, infection prevention, and control and antimicrobial stewardship.

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Serum C-reactive protein level after ventral hernia repair with mesh reinforcement can predict infectious complications: a retrospective cohort study

Cited by 13 publications

References 30 publications

Predictive value of C-reactive protein levels for the early and later detection of postoperative complications after cytoreductive surgery and HIPEC

Predictive value of C-reactive protein levels for the early and later detection of postoperative complications after cytoreductive surgery and HIPEC

Comment on “Serum C-reactive protein level after ventral hernia repair with mesh reinforcement can predict infectious complications: a retrospective cohort study”

Antimicrobial Challenge in Acute Care Surgery

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