Serum C-Reactive Protein Concentration as an Indicator of Remission Status in Dogs with Multicentric Lymphoma

Nielsen, Lise Nikolic; Toft, Nils; Eckersall, P. D.; Mellor, D. J.; Morris, Joanna S.

doi:10.1892/07-058.1

Cited by 43 publications

(65 citation statements)

References 24 publications

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“…The present study showed significantly increased serum AGP levels in dogs with carcinoma, sarcoma, and lymphoma (round cell tumor), when compared with healthy dogs. This supports the findings of Ogilvie et al (1993), Hahn et al C-reactive protein, serum amyloid A, and haptoglobin are all acute-phase proteins (APPs) like AGP, and are known to be elevated in some mammary tumors and lymphomas in dogs (Nielsen et al 2007;Tecles et al 2009). However, the dynamics of these APPs in other tumors are not well known.…”

Section: Discussionsupporting

confidence: 89%

Investigation of serum concentrations and immunohistochemical localization of α1-acid glycoprotein in tumor dogs

et al. 2010

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The purpose of this study was to measure the dynamics of serum α1-acid glycoprotein (AGP) concentration in dogs with various tumors, and to investigate the localization of AGP in some tissues using immunohistochemical staining. Sera were obtained from 171 dogs bearing tumors of various types. Serum AGP concentration was measured by single radial immunodiffusion. Tumors occurring in the liver and spleen were also investigated immunohistochemically using anti-canine AGP antibody. Mean serum AGP levels were 749 ± 602 mg/L in dogs with carcinoma (n = 39), 1,014 ± 971 mg/L with sarcoma (n = 18), and 887 ± 935 mg/L with round cell tumors (n = 46), all significantly higher than serum AGP level in healthy dogs (n = 137, 364 ± 106 mg/L). Mean serum AGP levels were significantly higher than in healthy dogs in complex mammary gland carcinoma (n = 5, 876 ± 721 mg/L), malignant melanoma (n = 7, 1,010 ± 821 mg/L), and hepatocellular carcinoma (n = 5, 936 ± 741 mg/L) among carcinomas, hemangiosarcoma (n = 5, 1,740 ± 1,323 mg/L) among sarcomas, and lymphoma (n = 19, 1,072 ± 965 mg/L) and histiocytic tumor (n = 6, 1,800 ± 1,387 mg/L) among round cell tumors. In an immunohistochemical investigation of AGP localization, both weak and strong staining for anti-AGP antibody were seen in hepatic tissue in dogs with primary non-tumorous lesions originating in the spleen (hematoma) and elevated serum AGP, but all tumor tissue in the spleen was negative. Among dogs with primary tumor lesions of the spleen (hemangiosarcoma) and elevated serum AGP levels, both weak, moderate and strong staining for anti-AGP antibody were seen in hepatic tissue, while strong positive staining was apparent in all tumorous tissue from the spleen. In primary tumor lesions in the liver (hepatocellular carcinoma), both moderate and strong staining for anti-AGP antibody were seen in normal hepatic tissue, and both weak, moderate and strong staining were seen in tumor tissues of the liver. AGP levels thus appear to be elevated in dogs with carcinomas, sarcomas, and round cell tumors. With some of these malignant tumors, localization of AGP in tumor tissue was seen.

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Section: Discussionsupporting

confidence: 89%

Investigation of serum concentrations and immunohistochemical localization of α1-acid glycoprotein in tumor dogs

et al. 2010

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“…However, as a biomarker it is not disease specific. 3,[11][12][13] Coupling biomarkers for rapid cell proliferation and inflammation has a strong relevance to the neoplastic process and malignant transformation. Chronic inflammation has been shown to predispose a patient to the development of neoplasia.…”

Section: Tests For Lymphoma Veterinary Diagnostics Institute Tkcanine1mentioning

confidence: 99%

“…12 In human oncology, serum CRP concentrations have shown potential as diagnostic and prognostic markers in various neoplastic diseases, including epithelial ovarian cancer, thymic cell carcinoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, and multiple myeloma. 12 Specifically, in lymphoma it has been used as a prognostic factor and as a marker for remission and relapsed disease and correlated with stage and substage of affected patients. 12,13,19 A 2005 study by Tecles and colleagues 13 evaluated serum concentrations of APPs haptoglobin, ceruloplasmin, serum amyloid A, and CRP in dogs.…”

Section: Sensitest/petscreen/tri-screen/canine Lymphoma Blood Testmentioning

confidence: 99%

“…12 Specifically, in lymphoma it has been used as a prognostic factor and as a marker for remission and relapsed disease and correlated with stage and substage of affected patients. 12,13,19 A 2005 study by Tecles and colleagues 13 evaluated serum concentrations of APPs haptoglobin, ceruloplasmin, serum amyloid A, and CRP in dogs. The sample cohorts included 15 healthy dogs, 12 with acute inflammation, 16 with hematologic cancer, 20 with nonhematologic cancer, and 8 with immune-mediated hemolytic anemia.…”

Section: Sensitest/petscreen/tri-screen/canine Lymphoma Blood Testmentioning

confidence: 99%

“…This would suggest a need for establishment of baseline levels in an individual patient if these values were to be used for monitoring the disease process in a particular patient. 12 A study by Merlo and colleagues 11 studied the concentrations of serum cCRP in dogs with multicentric lymphoma treated with chemotherapy. Of the 20 dogs with multicentric lymphoma, only 4 had an increased serum cCRP concentration at the time of relapse.…”

Section: Sensitest/petscreen/tri-screen/canine Lymphoma Blood Testmentioning

confidence: 99%

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Acute phase proteins (APP) were first identified in the early 1900s as early reactants to infectious disease. They are now understood to be an integral part of the acute phase response (APR) which is the cornerstone of innate immunity. APP have been shown to be valuable biomarkers as increases can occur with inflammation, infection, neoplasia, stress, and trauma. All animals--from fish to mammals--have demonstrable APP, but the type of major APP differs by species. While the primary application of these proteins in a clinical setting is prognostication, studies in animals have demonstrated relevance to diagnosis and detection and monitoring for subclinical disease. APP have been well documented in laboratory, companion, and large animals. With the advent of standardized and automated assays, these biomarkers are available for use in all fields of veterinary medicine as well as basic and clinical research.

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Serum C-Reactive Protein Concentration as an Indicator of Remission Status in Dogs with Multicentric Lymphoma

Cited by 43 publications

References 24 publications

Investigation of serum concentrations and immunohistochemical localization of α1-acid glycoprotein in tumor dogs

Investigation of serum concentrations and immunohistochemical localization of α1-acid glycoprotein in tumor dogs

Cancer Screening Tests for Small Animals

Acute Phase Proteins in Animals

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