Serum C-reactive protein and neutrophil-to-lymphocyte ratio as predictors of survival in cirrhotic patients with systemic inflammatory response syndrome and bacterial infection

Tapadia, Ashishkumar; Jain, Mayank; Reddy, Mettu Srinivas; Mahadevan, B; Varghese, Joy; Venkataraman, Jayanthi

doi:10.1007/s12664-020-01134-8

Cited by 3 publications

(2 citation statements)

References 27 publications

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“… Study Liver disease No. of patients Markers measured Outcome assessed Significance Vijayalekshmi, et al 54 Severe alcoholic hepatitis 50 Plasma VWF antigen 3-month mortality adjusted HR: 1.002 (95% CI: 1- 1.004) Tiwari, et al 55 Severe alcoholic hepatitis 34 Plasma VWF collagen binding activity In–hospital mortality (hospital stay: 6 days, median) AUC: 0.72 (95% CI: 0.54-0.89) Prasanna, et al 36 ACLF (as defined by APASL criteria) 50 Plasma VWF collagen binding activity In-hospital composite poor outcome a (hospital stay: 6 days, median) AUC: 0.68 (95% CI: 0.52-0.84) Grønbæk, et al 39 ACLF (as per EASL criteria) 185 Serum sCD163 3-month mortality AUC: 0.66 (0.59-0.73) Serum sMR AUC: (0.66 (0.59-0.72) ACLF: acute on chronic liver failure, APASL: Asia Pacific Association for Study of Liver, VWF: von Willebrand factor, AUC: Area under receiver operating curve, EASL: European Association for Study of Liver, sCD163: soluble CD163, sMR: soluble Mannose Receptor. a Composite poor outcome: Death/Liver transplant/Discharge in moribund state.…”

Section: Is the Liver An Immune Organ ( Table1 )?mentioning

confidence: 99%

“…Immune cells in peripheral blood: In hospitalized patients with cirrhosis and with ACLF, the ratio of neutrophils (innate immune cells) to lymphocytes (adaptive immune cells) - a marker of immune dysregulation - independently predicted 90-day mortality 53 , 54 .…”

Section: Indices Of Immune Activation In Cirrhosis and Aclf – Diagnostic Utility ( Table 2 )mentioning

confidence: 99%

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Recognizing Dysfunctional Innate and Adaptive Immune Responses Contributing to Liver Damage in Patients With Cirrhosis

Goel

Eapen

2022

Journal of Clinical and Experimental Hepatology

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Section: Is the Liver An Immune Organ ( Table1 )?mentioning

confidence: 99%

Section: Indices Of Immune Activation In Cirrhosis and Aclf – Diagnostic Utility ( Table 2 )mentioning

confidence: 99%

Recognizing Dysfunctional Innate and Adaptive Immune Responses Contributing to Liver Damage in Patients With Cirrhosis

Goel

Eapen

2022

Journal of Clinical and Experimental Hepatology

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Editorial commentary on the Indian Journal of Gastroenterology– May–June 2021

Limdi

2021

Indian J Gastroenterol

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Serum C-reactive protein and neutrophil to lymphocyte ratio as predictors of survival in cirrhotic patients with systemic inflammatory response syndrome and bacterial infection Patients with liver cirrhosis are at risk of significant morbidity and mortality from infectious complications [1]. Data on biochemical surrogates as predictors of infection are scarce. Tapadia et al. from Gleneagles Global Health City, Chennai, India assessed the predictive value of C-reactive protein (CRP) and the neutrophil-lymphocyte ratio (NLR) alone and in combination in predicting infection in a cohort of 208 consecutive hospitalized patients with cirrhosis [2].In addition to standard assessments (laboratory, ultrasound and appropriate cultures), CRP and NLR were also obtained. Investigators noted an infection rate of 62% with 58.5% culture positivity and mortality of 30.8%. Optimal cut-off values for NLR and CRP to predict infection were 5.86 and 33.7, respectively. One-month mortality risk was 2-3 times with NLR and CRP above these cut-off values. The combination of NLR + CRP (≥5.86 and ≥ 33.7) increased specificity and diagnostic accuracy for infection suggesting that these may have a role in predicting infection and even culture positivity. Prospective controlled studies are needed to validate this interesting observation.

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Prognostic potential of inflammatory markers, oxidative status, thrombocyte indices, and renal biochemical markers in neonatal calf diarrhoea-induced systemic inflammatory response syndrome

Yanar,

Eren,

Aktaş

et al. 2023

Veterinary Immunology and Immunopathology

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Serum C-reactive protein and neutrophil-to-lymphocyte ratio as predictors of survival in cirrhotic patients with systemic inflammatory response syndrome and bacterial infection

Cited by 3 publications

References 27 publications

Recognizing Dysfunctional Innate and Adaptive Immune Responses Contributing to Liver Damage in Patients With Cirrhosis

Recognizing Dysfunctional Innate and Adaptive Immune Responses Contributing to Liver Damage in Patients With Cirrhosis

Editorial commentary on the Indian Journal of Gastroenterology– May–June 2021

Prognostic potential of inflammatory markers, oxidative status, thrombocyte indices, and renal biochemical markers in neonatal calf diarrhoea-induced systemic inflammatory response syndrome

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