Serum C-peptide concentration and prostate cancer

Guo, Zhenlang; Weng, Xiang-Tao; Chan, Franky L.; Gong, Leiliang; Xiang, Shulin; Gan, Shu; Gu, Chiming; Wang, Shusheng

doi:10.1097/md.0000000000011771

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…The advancement of PCa may be associated with markers of insulin resistance, such as increased glucose and glycohemoglobin levels. Research has indicated that males with increased levels of glucose, insulin, and glycated hemoglobin are more vulnerable to PCa-related death or metastases [31][32][33][34][35]. Studies have shown that individuals with higher plasma glucose, insulin, and glycated hemoglobin levels have a higher risk of developing metastatic disease or dying from PCa [36][37][38][39][40][41][42].…”

Section: Discussionmentioning

confidence: 99%

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and Prostate specific antigen (PSA): a cross-sectional study

Huang,

Lin,

Xiao

et al. 2024

Preprint

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Background There is mounting evidence that prostate-specific antigen (PSA) levels can be influenced by lipid metabolism. However, there is still no clear relationship between PSA levels and the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR). This study's goal is to evaluate the association between PSA and NHHR by using data from the National Health and Nutrition Examination Survey (NHANES). Methods We used data from the NHANES from 2003 to 2010 to examine the connection between PSA and NHHR. Out of 41,156 participants, 6,015 met our inclusion criteria. Serum triglycerides served as our independent variable, while PSA was the dependent variable. Results The study's participants were 59.7 years old on average, with a standard deviation of 12.7 years. After controlling for potential confounding variables, a one-unit increment in NHHR was associated with a decrease of 0.15 ng/mL in PSA levels, with a 95% confidence interval ranging from − 0.22 to -0.08, indicating a statistically significant inverse relationship. Moreover, a restricted cubic spline analysis further corroborated the presence of a statistically significant, largely inverse association between NHHR and PSA concentrations. Conclusions Among American males, NHHR is inversely correlated with PSA. This negative correlation might make it challenging for men with higher triglycerides to detect asymptomatic prostate cancer and achieve early diagnosis.

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Section: Discussionmentioning

confidence: 99%

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and Prostate specific antigen (PSA): a cross-sectional study

Huang,

Lin,

Xiao

et al. 2024

Preprint

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“…No difference in the serum C-peptide level was observed between the nBMI patients and the healthy controls. The meta-analysis by Guo et al [ 76 ] indicated that the C-peptide concentration was not associated with an increased risk of prostate cancer. On the other hand, the studies of Arcidiacono et al [ 77 ] indicated that the level of C-peptide may correlate with the development of Barrett’s esophageal carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Concentration of Selected Adipokines and Factors Regulating Carbohydrate Metabolism in Patients with Head and Neck Cancer in Respect to Their Body Mass Index

Nuszkiewicz

Czuczejko

Dróżdż

et al. 2023

IJMS

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Head and neck cancers (HNCs) are a group of tumors not common in European populations. So far, not much is known about the role of obesity, adipokines, glucose metabolism, and inflammation in the pathogenesis of HNC. The aim of the study was to determine the concentrations of ghrelin, omentin-1, adipsin, adiponectin, leptin, resistin, visfatin, glucagon, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), plasminogen activator inhibitor-1 (PAI-1), and gastric inhibitory peptide (GIP) in the blood serum of HNC patients depending on their body mass index (BMI). The study included 46 patients divided into two groups according to their BMI values: the normal BMI group (nBMI) included 23 patients with BMI < 25 kg/m2 and the increased BMI group (iBMI) included patients with BMI ≥ 25 kg/m2. A control group (CG) included 23 healthy people (BMI < 25 kg/m2). Statistically significant differences in the levels of adipsin, ghrelin, glucagon, PAI-1, and visfatin were shown between nBMI and CG. In the case of nBMI and iBMI, statistically significant differences were observed in the concentrations of adiponectin, C-peptide, ghrelin, GLP-1, insulin, leptin, omentin-1, PAI-1, resistin, and visfatin. The obtained results indicate a disruption of endocrine function of adipose tissue and impaired glucose metabolism in HNC. Obesity, which is not a typical risk factor for HNC, may aggravate the negative metabolic changes associated with this type of neoplasm. Ghrelin, visfatin, PAI-1, adipsin, and glucagon might be related to head and neck carcinogenesis. They seem to be promising directions for further research.

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“…level, have shown lower risks in relation to PCa, [2][3][4][5] especially localised PCa. However, these findings could be due to delayed detection of PCa in men with obesity and type 2 diabetes mellitus (T2DM), both common conditions in men with insulin resistance and also related to lower levels of prostate-specific antigen (PSA) and potentially less PCa screening.…”

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confidence: 95%

“…Insulin resistance is related to a higher risk of several forms of cancer 1 but in relation to prostate cancer (PCa), the commonest cancer in men in high‐income countries, evidence remains unclear. Some markers of insulin resistance, including elevated plasma glucose and glycated haemoglobin (HbA1c), a marker of long‐term blood glucose level, have shown lower risks in relation to PCa, 2–5 especially localised PCa. However, these findings could be due to delayed detection of PCa in men with obesity and type 2 diabetes mellitus (T2DM), both common conditions in men with insulin resistance and also related to lower levels of prostate‐specific antigen (PSA) and potentially less PCa screening 6–8 .…”

Section: Introductionmentioning

confidence: 99%

Prediagnostic markers of insulin resistance and prostate cancer risk and death: A pooled study

et al. 2023

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Serum C-peptide concentration and prostate cancer

Abstract: Supplemental Digital Content is available in the text

Cited by 7 publications

References 33 publications

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and Prostate specific antigen (PSA): a cross-sectional study

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and Prostate specific antigen (PSA): a cross-sectional study

Concentration of Selected Adipokines and Factors Regulating Carbohydrate Metabolism in Patients with Head and Neck Cancer in Respect to Their Body Mass Index

Prediagnostic markers of insulin resistance and prostate cancer risk and death: A pooled study

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