Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance

Iwasaki, Tomoyuki; Yoneda, Masato; Nakajima, Atsushi; Terauchi, Yasuo

doi:10.2169/internalmedicine.46.0049

Cited by 118 publications

(80 citation statements)

References 22 publications

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“…). In comparison with AChE, BuChE is not constituted in situ but in different organs, mainly in the liver 11 . BuChE reaches serum levels of 5 mg/ml with a half time of 12 days 12 .…”

Section: Butyrylcholinesterasementioning

confidence: 93%

Cholinesterases, a Target of Pharmacology and Toxicology

Pohanka¹

2011

BIOMED PAP

313

219

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Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and acetylcholinesterase (AChE), AChE plays the key role in ending cholinergic neurotransmission. Cholinesterase inhibitors are substances, either natural or man-made that interfere with the break-down of ACh and prolong its action. Hence their relevance to toxicology and pharmacology.Methods and Results. The present review summarizes current knowledge of the cholinesterases and their inhibition. Particular attention is paid to the toxicology and pharmacology of cholinesterase-related inhibitors such as nerve agents (e.g. sarin, soman, tabun, VX), pesticides (e.g. paraoxon, parathion, malathion, malaoxon, carbofuran), selected plants and fungal secondary metabolites (e.g. aflatoxins), drugs for Alzheimer's disease (e.g. huperzine, metrifonate, tacrine, donepezil) and Myasthenia gravis (e.g. pyridostigmine) treatment and other compounds (propidium, ethidium, decamethonium).Conclusions. The crucial role of the cholinesterases in neural transmission makes them a primary target of a large number of cholinesterase-inhibiting drugs and toxins. In pharmacology, this has relevance to the treatment of neurodegenerative disorders.

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“…). In comparison with AChE, BuChE is not constituted in situ but in different organs, mainly in the liver 11 . BuChE reaches serum levels of 5 mg/ml with a half time of 12 days 12 .…”

Section: Butyrylcholinesterasementioning

confidence: 93%

Cholinesterases, a Target of Pharmacology and Toxicology

Pohanka¹

2011

BIOMED PAP

313

219

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“…However, the results obtained in the present study support the findings of Iwasaki and cols. (45) which indicate that BChEA is associated with the parameters of adiposity, serum lipid profile and the degree of insulin resistance. This current study suggests that BCHEA activities were more frequently correlated to obesity and metabolic syndrome disorder than to just the β-cell dysfunction in the CHE2 C5-DM1 group.…”

Section: Butyrylcholinesterase and Diabetes Mellitusmentioning

confidence: 93%

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Cwiertnia

Alcântara

Réa

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To investigate the relationship between butyrylcholinesterase (BChE) activities (total and band specific) and diabetes mellitus. Subjects and methods: BChE activities (BChEA, AC 4/5 , AC OF and RC 5 ) were analyzed in 101 type 1 (DM1) and in 145 type 2 (DM2) diabetic patients, in relation to phenotype, weight and incidence of metabolic syndrome (MS) in these patients. The C 4/5 and C 5 complex were separated from other molecular forms (C OF ) using an acid agar gel. Results: The BChE activity (BChEA) and the absolute activities of C 4/5 (AC 4/5 ) and C OF (AC OF ) showed a high positive correlation coefficient to weight in the CHE2 C5-group, while the relative activity of C 5 complex (RC 5 ) showed a negative correlation to weight. Conclusions: The present study suggests that the positive correlation of the BChE activities to diabetes mellitus and to insulin resistance may depend on the CHE2 locus variability. High values of BChE activities were associated with insulin resistance only in CHE2 C5-diabetic patients, while in CHE2 C5+ diabetic patients, the presence of C 5 complex, especially in a relatively high proportion, leads to less fat storage and better protection against metabolic syndrome. Arq Bras Endocrinol Metab. 2010;54(1):60-7 Keywords BCHE and CHE2 loci; C 4/5 and C 5 complexes; obesity, insulin resistance; metabolic syndrome; serum cholinesterase RESUMO Objetivo: Investigar a associação entre as atividades (total e banda específica) da butirilcolinesterase (BChE) e diabetes melito. Sujeitos e métodos: As atividades da BChE (BChEA, AC 4/5 , AC OF e RC 5 ) foram analisadas em 101 pacientes diabéticos do tipo 1 (DM1) e 145 do tipo 2 (DM2) em relação aos fenótipos, ao peso e à incidência da síndrome metabólica. Os complexos C 4/5 e C 5 foram separados das outras formas moleculares (C OF ), usando gel de ágar ácido. Resultados: A atividade da BChE (BChEA) e as atividades absolutas de C 4/5 (AC 4/5 ) e de C OF (AC OF ) mostraram altos coeficientes de correlações positivos com peso no grupo de CHE2 C5-, enquanto a atividade relativa do complexo C 5 (RC 5 ) mostrou correlação negativa com o peso. Conclusões: O presente estudo sugere que as correlações positivas das atividades da BChE com diabetes melito e com a resistência à insulina podem depender da variabilidade do loco CHE2. Altos valores nas atividades da BChE estão associados com a resistência à insulina somente nos pacientes diabéticos CHE2 C5-, enquanto nos pacientes diabéticos CHE2 C5+ a presença do complexo C 5 , especialmente em alta proporção relativa, leva a um menor estoque de gordura e à maior proteção contra a síndrome metabólica. Arq Bras Endocrinol Metab. 2010;54(1):60-7 DescritoresLocos BCHE e CHE2; complexos C 4/5 e C 5 ; obesidade, resistência à insulina; síndrome metabólica; colinesterase do soro

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“…These are acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) [13] . Pseudocholinesterase or butrylcholinesterase is an enzyme synthesized in various tissues that include liver, brain, lungs and heart and the enzyme has many roles in tissues such as lipoprotein metabolism [14] , myelin maintenance [15] , neurogenesis and neurite growth [16] .…”

Section: Introductionmentioning

confidence: 99%

“…Butyrylcholinesterase hydrolyses butyrylcholine at higher rate than acetylcholine and propionylcholine [17] . However until now many studies were performed physiological functions of the enzyme remains unknown [13] . Diagnosis of botulism is not so challenge but few of biochemistry analysis investigated.…”

Section: Introductionmentioning

confidence: 99%

Botulismuslu İneklerde Serum Haptoglobulin, Seruloplazmin ve Pseudokolinesteraz Seviyelerinin Değerlendirilmesi

Aytekin¹,

Kaya²,

Atalay³

2016

Kafkas Univ Vet Fak Derg

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The aim of this study was to determine serum pseudocholinesterase, rheumatoid factor, troponin I, C-reactive protein, caeruloplasmin, haptoglobin, urea, creatinin, creatinin kinase (CK), phosporus, calcium, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in cows with or without botulism. The study included 15 holstein cows aged two to five years as the botulism group and control group consisting of 10 healthy cows. The group included both pregnant and dry period cattle. Serum concentration of all the parameters were measured using an autoanalyzer and Nefelometre equipment BNII. Mice inoculation test was performed to make diagnosis and Clostridium Botulinum type C and D toxins were determined in silage and blood that cows with botulism. Serum troponin I, C-reactive protein, rheumatoid factor, creatinine, creatinine kinase, phosphorus, calcium and AST did not differ significantly between two groups. Biochemistry analysis of serum showed that in the botulism group haptoglobin, caeruloplasmin and urea were higher and that pseudocholinesterase and alanine aminotransferase were lower than in the control group. Serum haptoglobin, caeruloplasmin, urea, alanine aminotransferase and especially pseudocholinesterase concentrations may prove beneficial to the prognosis of botulism. Keywords: Botulism, Cow, Toxin, Pseudocholinesterase, Ceruloplasmin, Haptoglobin Botulismuslu İneklerde Serum Haptoglobulin, Seruloplazmin ve Pseudokolinesteraz Seviyelerinin Değerlendirilmesi ÖzetBu çalışmada botulismuslu ve sağlıklı ineklerde serum pseudokolinesteraz, seruloplazmin, haptoglobin, romatoid faktör, troponin I, C-reactive protein, üre, kreatin, kreatin kinaz (CK), alanine aminotransferase (ALT) ve aspartate aminotransferase (AST), fosfor ve kalsiyum seviyeleri araştırıldı. Çalışma ve kontrol grubunu gebe ve kuru dönemde iki ile beş yaşları arasında değişen 15 adet botulismuslu ve 10 adet sağlıklı holştayn inek oluşturdu. Parametrelerin serum düzeyleri Nefelometre BNII ve otoanalizör kullanılarak ölçüldü. Botilusmuslu hayvanların kan serumlarından ve silajdan fare inokulasyon testi yapılarak clostridium botulinum tip C ve tip D toksini tespit edildi. Serum troponin I, C-reactive protein, romatoid faktör, kreatin, kreatin kinaz, AST, fosfor ve kalsiyum seviyeleri botulismuslu ve sağlıklı ineklerde önemli bir değişiklik göstermedi. Botulismuslu ineklerde haptoglobin, seruloplazmin ve üre yüksek çıkarken, ALT ve pseudokolinesterazın sağlıklı ineklere göre daha düşük çıktığı tespit edildi. Botulismuslu ineklerde serum üre, ALT, haptoglobin, seruloplazmin ve özellikle pseudokolinesteraz düzeylerinin belirlenmesi botulismusun prognozuna faydalı olabileceği sonucuna varıldı.

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Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance

Cited by 118 publications

References 22 publications

Cholinesterases, a Target of Pharmacology and Toxicology

Cholinesterases, a Target of Pharmacology and Toxicology

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Botulismuslu İneklerde Serum Haptoglobulin, Seruloplazmin ve Pseudokolinesteraz Seviyelerinin Değerlendirilmesi

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