Serum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: Effects of choline administration

Protective effects of S-adenosylmethionine (SAMe) and silybin on hepatorenal and hemostatic functions in dogs with endotoxemia

“…A possible mechanism is that SAMe and silybin in combination could inhibit the inflammation and oxidative stress that are associated with liver injury and development of liver diseases (18). Our previous studies showed that oxidative stress inhibition by choline treatment resulted in decreased sepsis severity and good prognosis in dogs with endotoxemia (27).…”

Serum paraoxonase 1 (PON1) measurement: an update

“…But more recently research has been focused on other clinical aspects such as protective role in vascular disease as well as its use as biomarker of diseases involving mainly three situations: (a) oxidative stress, since PON1 protects against oxidation [8]; (b) inflammation, being considered PON1 as a negative acute phase protein [9] and (c) liver diseases, because PON1 is synthesized in this organ [10]. In veterinary medicine, studies of PON1 have been traditionally focused in bovine [11,12], however in recent years it has gained interest in other species such as dogs [13,14], cats [15] and horses [16]. …”

Inflammatory and oxidative biomarkers of disease severity in dogs with parvoviral enteritis

“…A drop in activity of the two enzymes (BChE and PON1) has been observed in experimentally induced endotoxaemia in dogs (Tvarijonaviciute et al . ) and in naturally occurring sepsis in humans and experimental animals (Novak et al . ).…”