Serum brain‐derived neurotrophic factor (<scp>BDNF</scp>) in sleep‐disordered patients: relation to sleep stage N3 and rapid eye movement (<scp>REM</scp>) sleep across diagnostic entities

Deuschle, Michael; Schredl, Michael; Wisch, Christian; Schilling, Cláudia; Gilles, Maria; Geisel, Olga; Hellweg, Rainer

doi:10.1111/jsr.12577

Cited by 42 publications

(29 citation statements)

References 26 publications

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“…An epidemiological survey revealed that serum BDNF levels are lower in women with sleep disturbances [ 19 ]. Other studies have reported that serum BDNF levels are correlated with perceived severity of insomnia [ 20 ], and polysomnographically confirmed disturbances in non-rapid eye movement sleep [ 21 ], i.e., reduced theta EEG activity and reduced percentage of deep non-rapid eye movement sleep. These studies imply that BDNF may participate in homeostatic regulation of sleep that controls brain recovery.…”

Section: Introductionmentioning

confidence: 90%

Association of serum BDNF levels and the BDNF Val66Met polymorphism with the sleep pattern in healthy young adults

et al. 2018

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BackgroundBrain-derived neurotrophic factor (BDNF) is widely expressed in the brain and plays an important role in neuronal maintenance, plasticity, and neurogenesis. Prior studies have found that decreased serum BDNF levels are associated with perceived stress, depression, or sleep disturbances in humans.Study objectivesTo elucidate whether the serum BDNF levels and BDNF genotype were associated with the sleep pattern in healthy young adults.MethodsThe study group consisted of 79 healthy paid volunteers (45 men, 34 women) aged 20 to 29 years. Serum BDNF levels were measured with an enzyme-linked immunosorbent assay, and a single-nucleotide polymorphism (Val66Met) in the BDNF gene was assessed with a TaqMan assay. Details of the sleep pattern were obtained from 1-week sleep/wake records.ResultsSerum BDNF levels were significantly associated with sleep parameters on weekends, whereas no such association was found on weekdays. On weekends, longer total sleep time and time in bed, and later mid-sleep time were associated with lower serum BDNF levels. The difference between mid-sleep time on weekdays and that on weekends, otherwise known as social jetlag, was negatively associated with serum BDNF levels. Met/Met homozygotes of the BDNF Val66Met polymorphism had significantly longer time in bed on weekends than Val/Val homozygotes. Heterozygotes did not differ from Val/Val homozygotes.ConclusionsWe first found that serum BDNF levels and the BDNF Val66Met polymorphism in healthy young adults were associated with the sleep pattern on weekends but not with that on weekdays, suggesting that the systems involved in BDNF control may be linked to endogenous sleep characteristics rather than the socially constrained sleep schedule in healthy young adults.

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Section: Introductionmentioning

confidence: 90%

Association of serum BDNF levels and the BDNF Val66Met polymorphism with the sleep pattern in healthy young adults

et al. 2018

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“…It remains unclear whether an increase in brain BDNF accounts for the sleep-deepening effects of exercise in humans. For instance, a study including a group of participants with heterogeneous sleep problems found that those with higher basal serum BDNF concentrations have lower SWS and REM sleep [ 52 ]. Of note, serum BDNF levels are increased two-to three-fold after acute exercise compared to resting conditions [ 53 ].…”

Section: Bdnfmentioning

confidence: 99%

“…Of note, serum BDNF levels are increased two-to three-fold after acute exercise compared to resting conditions [ 53 ]. Thus, it remains unclear whether exercise-induced increases in blood and brain BDNF concentrations would show similar negative associations with time spent in SWS and REM sleep as described under rest conditions in [ 52 ].…”

Section: Bdnfmentioning

confidence: 99%

The role of exercise-induced peripheral factors in sleep regulation

Tan

Egmond

Cedernaes

2020

Molecular Metabolism

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Background Recurrently disrupted sleep is a widespread phenomenon in our society. This is worrisome as chronically impaired sleep increases the risk of numerous diseases that place a heavy burden on health services worldwide, including type 2 diabetes, obesity, depression, cardiovascular disease, and dementia. Therefore, strategies mitigating the current societal sleep crisis are needed. Scope of review Observational and interventional studies have found that regular moderate to intensive exercise is associated with better subjective and objective sleep in humans, with and without pre-existing sleep disturbances. Here, we summarize recent findings from clinical studies in humans and animal experiments suggesting that molecules that are expressed, produced, and released by the skeletal muscle in response to exercise may contribute to the sleep-improving effects of exercise. Major conclusions Exercise-induced skeletal muscle recruitment increases blood concentrations of signaling molecules, such as the myokine brain-derived neurotrophic factor (BDNF), which has been shown to increase the depth of sleep in animals. As reviewed herein, BDNF and other muscle-induced factors are likely to contribute to the sleep-promoting effects of exercise. Despite progress in the field, however, several fundamental questions remain. For example, one central question concerns the optimal time window for exercise to promote sleep. It is also unknown whether the production of muscle-induced peripheral factors promoting sleep is altered by acute and chronic sleep disturbances, which has become increasingly common in the modern 24/7 lifestyle.

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“…These findings are supported by clinical studies. In particular a very recent study by Deuschle et al [61] measured morning serum BDNF levels followed by sleep polysomnography in a significant number of participants with either primary insomnia, restless legs syndrome, idiopathic hypersomnia or narcolepsy as well as healthy controls. Across all disorders low BDNF levels were associated with a low percentage of SWS and REM sleep [61] consistent with translational studies indicating the importance of BDNF in generating the homeostatic drive for SWS and REM.…”

Section: Bdnf and Sleepmentioning

confidence: 99%

“…In particular a very recent study by Deuschle et al [61] measured morning serum BDNF levels followed by sleep polysomnography in a significant number of participants with either primary insomnia, restless legs syndrome, idiopathic hypersomnia or narcolepsy as well as healthy controls. Across all disorders low BDNF levels were associated with a low percentage of SWS and REM sleep [61] consistent with translational studies indicating the importance of BDNF in generating the homeostatic drive for SWS and REM. Conversely, full or partial sleep deprivation, which increases sleep pressure and has been reported in several studies to produce a rapid reduction in depressive symptoms, leads to a rapid increase in BDNF levels [62].…”

Section: Bdnf and Sleepmentioning

confidence: 99%

Thermoregulatory Fear of Harm Mood Disorder: In Depth Exploration of a Unique Juvenile-Onset Phenotype That Provides a Parsimonious Clinical Description of Certain Youths with Highly Comorbid Treatment Refractory Psychiatric Disorders

Papolos¹,

Mattis²,

Lachman³

et al. 2019

J Psychiatry Brain Sci

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Among aggressive youths with severe mood lability who frequently fail to benefit from mood stabilizers and antipsychotics there is a discrete subtype called 'Thermoregulatory Fear of Harm Mood Disorder' (FOH). This disorder is characterized by an underlying thermoregulatory deficit, a specific prodromal sequence and a unique constellation of symptoms.The underlying problem appears to be a deficit in thermoregulation resulting in excessive heat that manifests as thermal discomfort in neutral ambient temperatures and moderate to extreme cold tolerance, and produces REM sleep-related problems and parasomnias, such as night-terrors and hypnogogic hallucinations. Clinically, FOH is associated with the advent in childhood of frequent, recurrent, vivid nightmares with themes of pursuit and abandonment. The apparent psychological sequelae of exposure to this frightening imagery is fear sensitization and auto-traumatization. A developmental sequence of fear based defensive behaviors arises and includes obsessive bedtime rituals, fear of the dark, separation anxiety, contamination fears, hypervigilance, perfectionism, misperception of neutral stimuli as threatening, as well as reactive aggression in response to limit setting and perceived threat or loss. Ketamine, chosen as a potential treatment because of its effectiveness in reducing fear sensitization and dose-dependent lowering of body temperature in preclinical studies, has been associated with sustained Journal of Psychiatry and Brain Science 2 of 43 J Psychiatry Brain Sci. 2019;4:e190004. https://doi.org/10.20900/jpbs.20190004 improvement in otherwise refractory youths. We present a detailed description of this heritable disorder, link its clinical features to a potential disturbance in brain derived neurotropic factor (BDNF) and orexin, and indicate how ketamine rapidly affects BDNF through multiple mechanisms, to produce a dramatic beneficial response in youths with this disorder.

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Serum brain‐derived neurotrophic factor (BDNF) in sleep‐disordered patients: relation to sleep stage N3 and rapid eye movement (REM) sleep across diagnostic entities

Cited by 42 publications

References 26 publications

Association of serum BDNF levels and the BDNF Val66Met polymorphism with the sleep pattern in healthy young adults

Association of serum BDNF levels and the BDNF Val66Met polymorphism with the sleep pattern in healthy young adults

The role of exercise-induced peripheral factors in sleep regulation

Thermoregulatory Fear of Harm Mood Disorder: In Depth Exploration of a Unique Juvenile-Onset Phenotype That Provides a Parsimonious Clinical Description of Certain Youths with Highly Comorbid Treatment Refractory Psychiatric Disorders

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