Serum brain‐derived neurotrophic factor levels in epilepsy

Zhao, Hong; Li, W.; Qu, Bo; Zou, Xinyu; Chen, J.; Sander, Josemir W.; Zhou, Dong

doi:10.1111/ene.12232

Cited by 45 publications

(40 citation statements)

References 30 publications

(32 reference statements)

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“…38 However, the different adult age group of their patients with mature women and a high estrogen level may explain the difference. We found a highly significant difference in the levels of serum and breastmilk BDNF in relation to duration of illness and frequency of seizures per month; this agrees with Hong et al, 30 who found significant negative correlations between seizure frequency and disease duration with serum BDNF levels. One of the objectives of our research was to assess the BDNF value as a marker of epilepsy severity, and we found significant differences in serum and breastmilk BDNF levels for epileptic infants with different disease severity, as the levels were significantly higher in the severe form than in the mild and moderate forms with a p < 0.0001.…”

Section: Discussionsupporting

confidence: 92%

“…One of the objectives of our research was to assess the BDNF value as a marker of epilepsy severity, and we found significant differences in serum and breastmilk BDNF levels for epileptic infants with different disease severity, as the levels were significantly higher in the severe form than in the mild and moderate forms with a p < 0.0001. So, serum and milk BDNF levels for epileptic infants are associated with disease severity and may be used as a helpful marker of severity, and this agrees with the results obtained by Hong et al 30 …”

Section: Discussionsupporting

confidence: 91%

“…In contrast, LaFrance et al 29 concluded that unlike children, adults with epilepsy appeared to have decreased levels of serum BDNF. But in another study carried out by Hong et al, 30 they found that BDNF levels in adult epileptic patients were not different from those of controls.…”

Section: Discussionmentioning

confidence: 85%

See 2 more Smart Citations

Brain-Derived Neurotrophic Factor in Sera of Breastfed Epileptic Infants and in Breastmilk of Their Mothers

Ismail

BabersGihan

RehanyMahmoud

2015

Breastfeeding Medicine

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Brain-Derived Neurotrophic Factor in Sera of Breastfed Epileptic Infants and in Breastmilk of Their Mothers

Ismail

BabersGihan

RehanyMahmoud

2015

Breastfeeding Medicine

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“…CREB does not only influence transcription in the nucleus, but also leads to cell wide supply of protein and mRNA that can localize to the synapse when the synapse has been tagged, thereby permitting LTP [88, 89]. One transcript targeted by CREB is the brain derived neurotrophic factor (BDNF) [92], which has been associated to temporal lobe epilepsy in many cases [93] and may serve as a serum marker for epilepsy [94]. …”

Section: Crebmentioning

confidence: 99%

mTOR and MAPK: from localized translation control to epilepsy

Pernice¹,

Schieweck²,

Kiebler³

et al. 2016

BMC Neurosci

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BackgroundEpilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse and not really understood. All in common is the misregulation of proteins that determine excitability such as potassium and sodium channels as well as GABA receptors; which are all known as biomarkers for epilepsy. Two recently identified key pathways involve the kinases mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinases (MAPK). Interestingly, mRNAs coding for those biomarkers are found to be localized at or near synapses indicating a local misregulation of synthesis and activity.ResultsResearch in the last decade indicates that RNA-binding proteins (RBPs) responsible for mRNA localization, stability and translation mediate local expression control. Among others, they are affected by mTOR and MAPK to guide expression of epileptic factors. These results suggest that mTOR/MAPK act on RBPs to regulate the fate of mRNAs, indicating a misregulation of protein expression at synapses in epilepsy.ConclusionWe propose that mTOR and MAPK regulate RBPs, thereby guiding the local expression of their target-mRNAs encoding for markers of epilepsy. Thus, misregulated mTOR/MAPK-RBP interplay may result in excessive local synthesis of ion channels and receptors thereby leading to hyperexcitability. Continuous stimulation of synapses further activates mTOR/MAPK pathway reinforcing their effect on RBP-mediated expression control establishing the basis for epilepsy. Here, we highlight findings showing the tight interplay between mTOR as well as MAPK with RBPs to control expression for epileptic biomarkers.

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“…Recently, it has been found that decreased plasma BDNF level in adults is reduced with epileptic seizures [14], while serum BDNF concentration in children with epilepsy has not been previously well described. Connolly et al [15] recorded no differences in serum BDNF concentrations between epileptic children and controls.…”

Section: Discussionmentioning

confidence: 99%

Serum Brain Derived Neurotrophic Factor as Biomarker for Epilepsy Diagnosis in Egyptian Children With Epilepsy; Relationship to Disease Severity and Cognitive Function.

El-Alameey

Ahmed

2018

Asian J Pharm Clin Res

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Objectives: This study was designed to estimate serum brain-derived neurotrophic factor (BDNF) concentration in a group of Egyptian children with epilepsy to clarify its utility as a biomarker for epilepsy diagnosis and to evaluate its relationship with their cognitive function and disease severity. Methods:Intelligence was assessed using Arabic version of the WISC-R test. Serum concentration of BDNF was assessed using enzyme-linked immunosorbent assay in 40 children with epilepsy and 40 apparently healthy children of matched age and sex controls.Results: Of total 40 epileptic patients aged 6-12 years, the mean age was 8.32 ± 0.7 years and male to female ratio was 1.5:1. The mean serum BDNF concentration and cognitive IQ scores were statistically significantly reduced in the studied patient's group versus to controls (p<0.001). There were highly significant differences in serum BDNF concentration as regards epileptic severity. Serum concentration of BDNF showed significantly positive correlation with cognitive, verbal, performance, and totals IQ scores and negative correlation with the age at the onset of seizures, and duration of therapy. The linear regression analysis showed a statistically significant association between age at the onset of seizures, duration of therapy, cognitive function, and serum BDNF concentrations among the studied patients. Conclusions:Concentration of BDNF in serum is involved in the mechanism of epileptogenesis in children with epilepsy. It should be used as a helpful marker for epilepsy diagnosis and detection of severity.

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Serum brain‐derived neurotrophic factor levels in epilepsy

Abstract: It seems that the concentration of BDNF in serum is associated with disease severity in people with epilepsy and may be a helpful marker for severity.

Cited by 45 publications

References 30 publications

Brain-Derived Neurotrophic Factor in Sera of Breastfed Epileptic Infants and in Breastmilk of Their Mothers

Brain-Derived Neurotrophic Factor in Sera of Breastfed Epileptic Infants and in Breastmilk of Their Mothers

mTOR and MAPK: from localized translation control to epilepsy

Serum Brain Derived Neurotrophic Factor as Biomarker for Epilepsy Diagnosis in Egyptian Children With Epilepsy; Relationship to Disease Severity and Cognitive Function.

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