Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Dyssomnia in Females, but not Males, among Japanese Workers

“…Because the serum BDNF levels have been reported to change according to age, 31 body weight, BMI, 32 depression, 16,17 metabolic disorders, including diabetes mellitus, [19][20][21] and regular exercise, 33,34 we adjusted the model for these potential confounding factors. The association between the serum BDNF levels and dyssomnia remained statistically significant even after adjusting for these confounders.…”

“…[13][14][15] Accumulating evidence shows the serum BDNF levels to be associated with psychiatric and metabolic disorders, including depression, 16,17 Alzheimer disease, 18 and diabetes mellitus. [19][20][21] However, no studies have examined the association between the serum BDNF levels and dyssomnia.…”

Posttraumatic stress disorder eliminates association of <i>TrkB rs1187327</i> with HDL-C in Chinese Han adolescents

“…BDNF-TrkB signaling pathway has been found to play an important role in lipid metabolism (19). However, the association of TrkB with serum lipid profiles has not been explored yet in human being, although it has been reported that there is a decreasing trend of HDL-C level in the transgenic mice overexpressing TrkB when compared with the control mice (25).…”

Comment on: Krabbe KS, Nielsen AR, Krogh-Madsen R et al (2007) Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50:431–438

“…Altogether, these data were conceptualised as a metabotrophin-deficit hypothesis of cardiometabolic disease, suggesting novel roles for NGF and BDNF in metabolic and vascular health and disease, that is, their metabotrophic potentials, including the improvement of glucose, lipid and antioxidant metabolism [3,4]. Accordingly, increased BDNF circulating levels documented in cardiometabolic disease [7][8][9] might be considered a protective phenomenon. Of note: (1) wounded diabetic skin reveals increased levels of NGF, whereas a local treatment with NGF benefits the healing process; and (2) experimentally induced cardiac ischaemia upregulates local NGF levels, whereas exogenously administered NGF improves the cardiac function [3].…”