Serum Bisphenol A Concentration in Postmenopausal Women with Osteoporosis

Abstract

ObjectivesBishphenol A (BPA) is a representative endocrine disruptor and is also known as a xenoestrogen. The objective of the present study is to investigate how many patients are exposed to BPA and to analyze the relationships between serum BPA concentration, bone mineral density (BMD) and biochemical bone markers in postmenopausal women with osteoporosis.MethodsTotal 51 patients were enrolled for measuring BPA and clinical variables including BMD and bone markers. The relationship between BPA and clinical variables were analyzed by the Pearson's correlation test and the Kruskal-Wallis test. Serum BPA concentration was measured by enzyme linked immunosorbent assay (ELISA).ResultsBPA was detected in all samples. The mean BPA concentration was 1.44 ± 0.52 ng/mL. There was no statistically significant correlation between BPA and clinical variables.ConclusionThere was no statistical significance between serum BPA concentration and clinical variables related to bone metabolism. To clarify the effect of BPA on bone metabolism, further large scaled and high risk group investigation may be needed.

Bisphenol A exposure and associations with obesity among adults: a critical review

“…Two studies (65,73) observed positive correlations between serum BPA levels and BMI. The other four studies did not observe an association between serum BPA concentrations and BMI (68,(77)(78)(79) . Only one of these studies reported adjusting for potential confounders, such as age or health status (79) .…”

“…For six of the articles, body composition (BMI, WC and/or weight) was the primary outcome of interest (62)(63)(64)67,71,74) . Seven studies included only women (65,67,69,73,74,77,78) , nine of the studies were in general adult populations (62)(63)(64)66,67,70,71,75,76) , one study included men and women ≥60 years (72) and another included only 70-year-old men and women (79) .…”

“…Urinary BPA levels are much higher and consist largely of conjugated BPA, which can only be formed in vivo, thus acting as a marker for ruling out contamination by extraneous sources (88) . In fourteen of the studies (64,(66)(67)(68)(69)(70)(71)(72)(73)(75)(76)(77)(78)(79) , including five of six studies that measured serum BPA levels, the manuscripts lacked sufficiently detailed information to determine whether BPA-free materials were used to collect, process and store biospecimens. Failure to use BPA-free laboratory materials could lead to sample contamination and inaccurate BPA measurements, particularly with serum measurements (64,65,67,68,73,88) .…”

“…Fourteen articles were found to be eligible for inclusion (62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75) . Four additional articles were identified in reference lists (76)(77)(78)(79) , for a final total of eighteen included articles. Reasons for exclusion included: not the study population of interest, no data on association between BPA levels and BMI, duplicate data, animal or in vitro study, review article and other (e.g.…”

The Application of SPECT in the Diagnosis of Osteoporotic Vertebral Compression Fractures

“…However, the severe osteoporosis results in a wide low back pain and thoracodorsal pain, and then bringing difficulties in diagnosing painful vertebrae through a general physical examination for many patients. X-ray and CT play an important role in diagnosing the fractured vertebral body, but they cannot diagnose the fractured vertebral body without obvious morphological changes and cannot clearly distinguish the differences between the painful vertebrae and old fractured vertebral body [11,12]. MRI is a type of tomography which uses the physical phenomenon of magnetic resonance to obtain the electromagnetic signal from the human body, and reconstruct the human body structure.…”