Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study

Zinkevičienė, Auksė; Kainov, Denis E.; Lastauskienė, Eglė; Kvedarienė, Violeta; Bychkov, Dmitrii; Byrne, Myles; Girkontaitė, Irutė

doi:10.1159/000442749

Cited by 15 publications

(11 citation statements)

References 21 publications

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“…Nevertheless, the mechanisms of the association between RBP-4 and these diseases are still unclear. It remains similar with the other allergic conditions [12,17].…”

Section: Discussionsupporting

confidence: 81%

“…In a case-control study of prepubertal children, high plasma RBP-4 levels correlated with lower forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) or forced expiratory flow at 25% and 75% (FEF25-75) in male asthmatics; however, no significant difference in its level was found between asthmatics and controls [12]. Zinkeviciene et al [17] suggested RBP-4 as a possible serum biomarker in allergic contact dermatitis. However, to our knowledge, none has examined their association in general populations.…”

Section: Discussionmentioning

confidence: 99%

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Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

Kim

Song

Seo

et al. 2021

Korean J Intern Med

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Background/Aims: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin sensitivity. We evaluated the association between metabolic parameters and allergic sensitization in the elderly. Methods: We analysed the database of the Korean Longitudinal Study on Health and Aging cohort study conducted during 2005 to 2006. Atopy was identified by inhalant allergen skin prick test. Metabolic conditions were assessed using anthropometric indices and serum biomarkers such as fasting glucose, lipid, adiponectin, and RBP-4. Results: Among the 854 elderly subjects, 17.2% had atopy. Plasma RBP-4 levels were significantly higher in the atopic elderly than nonatopic elderly (p = 0.003). When RBP-4 percentiles were categorized as under three groups, the prevalence of atopy and current rhinitis increased significantly with percentiles of RBP-4 levels (p = 0.019 and p = 0.007, respectively). Log RBP-4 was associated with atopy (odds ratio [OR], 4.10; p = 0.009) and current rhinitis (OR, 2.73; p = 0.014), but not with current asthma (OR, 1.17; p = 0.824). Higher RBP-4 level in atopic elderly was also observed in current rhinitis patients. Atopy, but not current rhinitis, showed significant relationships with log RBP-4 levels in multivariate analyses adjusted for other metabolic markers including body mass index. Conclusions: RBP-4 positively associated with atopy in the general elderly population irrespective of other metabolic markers.

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“…Nevertheless, the mechanisms of the association between RBP-4 and these diseases are still unclear. It remains similar with the other allergic conditions [12,17].…”

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

Kim

Song

Seo

et al. 2021

Korean J Intern Med

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“…Platelet factor 4 (PF4) and β-thromboglobulin (β-TG) are the most abundantly expressed CXC chemokines in platelet α-granules that could be released in high concentrations following activated platelets [48]. Significant differences in plasma levels of PF4 or β-TG were found between many inflammatory skin diseases and normal controls, such as systemic sclerosis [49], allergic contact dermatitis [50], and atopic dermatitis [51], elevated expression indicating the critical role of platelet activation. β-TG together with PF4 levels in psoriasis was also reported to be higher than in healthy controls, and PF4 levels were correlated with PASI [51].…”

Section: In the Role Of Psoriasis Inflammationmentioning

confidence: 99%

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

et al. 2020

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Background: Psoriasis is an immune-mediated inflammatory skin disease in conjunction with the systemic inflammatory process. It appears to be related to increased risks of cardiovascular disease events, especially in severe cases. The hemostatic balance is disrupted due to the prothrombotic bias in psoriasis, which might be mainly preserved by platelet hyperactivity. Platelets are also immune cells that initiate and regulate immune and inflammatory processes, except as the principal mediator of hemostasis and thrombosis, and platelet dysfunction is deeply involved in the pathogenesis of psoriasis. Summary: The aim of this study is to perform a review that expounds abnormal platelet function in psoriasis and explains the important role of platelets in the pathogenic mechanism of psoriasis in order to provide new targets for comprehensive medical treatment.

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“…[7] Increased hsCRP is found in many skin diseases including allergic contact dermatitis, mycosis fungoides, hidradenitis suppurativa, and psoriasis. [89101112] Increased CRP in psoriatic patients was correlated with active arthritis, psoriasis area severity index (PASI) score, and with an increased incidence of cardiovascular diseases. [13] Patients with increased hsCRP levels were found to have a better response to cyclosporine therapy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum adenosine deaminase and inflammatory markers in psoriatic patients

et al. 2019

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Background: Adenosine deaminase (ADA) is an enzyme involved in purine metabolism and it is a marker of nonspecific T-cell activation. Few studies have shown high levels of ADA in the epidermis and sera of psoriatic patients. Other inflammatory markers such as high-sensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), and serum uric acid (SUA) have shown correlations with psoriasis area severity index (PASI) score. The correlation between ADA and PASI score is still a matter of debate. Aims: The aim of this study was to evaluate serum ADA, hsCRP, SUA, and ESR in psoriatic patients and their correlation with PASI score. Patients and Methods: This study included 60 psoriatic patients divided according to PASI score into three groups (mild, moderate, and severe) each containing 20 patients. PASI score <10 was defined as mild, (10–20) moderate, and >20 severe. Twenty healthy subjects of matched age and sex were included as control. Serum ADA, hsCRP, SUA, and ESR were evaluated for patients and controls. Correlations of ADA, hsCRP, SUA, and ESR with PASI scores were done. Results: While ADA, hsCRP, SUA, and ESR showed a significant increase in psoriatic patients compared with that of the controls (P<001), they showed no significant difference between different psoriatic groups (P>0.05) and no correlations with PASI score (P>0.05). The frequency of joint affection increased with increasing severity of psoriasis (5%, 10%, and 25% in mild, moderate, and severe psoriasis, respectively). Conclusion: Serum ADA, hsCRP, SUA, and ESR showed higher levels among psoriatic patients than in controls. The increased ADA in psoriatic patients supports the role of T-cell activation and proliferative disorder in the pathogenesis of psoriasis. No significant correlations were found between these biomarkers and PASI score. Further studies are needed to validate these biomarkers as diagnostic and prognostic factors in psoriasis.

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Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study

Cited by 15 publications

References 21 publications

Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

Evaluation of serum adenosine deaminase and inflammatory markers in psoriatic patients

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