Serum biomarkers of aging in the Brown Norway rat

Gordon, Christopher J.; Rowsey, Pamela Johnson; Bishop, Britton L.; Ward, William O.; MacPhail, Robert C.

doi:10.1016/j.exger.2011.07.006

Cited by 21 publications

(28 citation statements)

References 18 publications

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“…The Brown Norway (BN) rat is an inbred strain with longevity and is suitable for use in aging studies [5, 12]. Age-dependent renal damages in BN rats was previously assessed and compared with those in other inbred rats, and it was found that chronic nephrosis progressed more slowly in BN rats [6].…”

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confidence: 99%

Age-Related Histological Changes in Kidneys of Brown Norway Rat

Yabuki

Yoneshige

Tanaka

et al. 2014

The Journal of Veterinary Medical Science

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In this study, age-dependent histological changes in the kidneys of Brown Norway rat, a strain useful for conducting aging research, were evaluated. Examination was performed at 3, 12, 18, 24 and 30 months of age. Sclerotic and hypertrophic changes of the glomeruli were observed, and quantitative scores of these changes persistently increased with age. A marginal increase in scores was observed for glomerular cystic changes and tubulointerstitial damage. Further, urothelial hyperplasia was observed in the renal papillae, particularly at 30 months of age. In conclusion, the findings of the present study demonstrate that the Brown Norway strain exhibits persistent, but mild progression of age-dependent renal histological changes.

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confidence: 99%

Age-Related Histological Changes in Kidneys of Brown Norway Rat

Yabuki

Yoneshige

Tanaka

et al. 2014

The Journal of Veterinary Medical Science

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“…In terms of variability and overall changes from 4 to 12 to 24 months, CRP and MDC-2 were concluded to be the most reliable indicators. Myoglobin was also a significant indicator but showed marked variability with age (Gordon et al, 2011). The current study found that several additional analytes were significantly influenced by age (Table 5).…”

Section: Discussionmentioning

confidence: 71%

“…A recent study from this laboratory used the same panel of biomarkers in 4-, 12-and 24-month-old BN rats (Gordon et al, 2011), and found just five analytes that were significantly affected by age (CRP, MDC-2, FGF-basic, myoglobin and VCAM). CRP showed a marked elevation with age from 4 to 24 months, whereas levels of the other analytes declined with age.…”

Section: Discussionmentioning

confidence: 93%

“…The current study found that several additional analytes were significantly influenced by age (Table 5). It is important to note that the rats in the current study were handled differently compared to the Gordon et al (2011) study. Rats in the earlier study were left undisturbed in home cages with very little manipulation, compared to the frequent handling and movement to exposure cages of the rats in the current study.…”

Section: Discussionmentioning

confidence: 96%

“…The functional significance of these two analytes in adult versus senescent rats exposed to O 3 is unknown. Myoglobin levels have been found to increase in aged humans but decrease in senescent BN rats (Gordon et al, 2011). That O 3 exposure in senescent rats led to an elevation in serum myoglobin levels was unexpected, but could nonetheless represent a unique serum biomarker of O 3 exposure in aged animals.…”

Section: Discussionmentioning

confidence: 97%

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Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function

Gordon¹,

Jarema²,

Lehmann³

et al. 2013

Inhalation Toxicology

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Ozone (O₃) is a pervasive air pollutant that produces pulmonary and cardiovascular dysfunction and possible neurological dysfunction. Young and old individuals are recognized as being susceptible to O₃; however, remarkably little is known about susceptibility with senescence. This study explored the pulmonary, cardiovascular and neurological effects of O₃ exposure in adult (4 m) and senescent (20 m) Brown Norway rats exposed to 0 or 0.8 ppm O₃ for 6 h, 1 d/week, for 17 weeks. Ventilatory function was assessed 1 and 7 d after each exposure (Buxco). Heart rate, blood pressure (tail cuff) and motor activity were measured biweekly. Blood, aorta and bronchoalveolar lavage fluid (BALF) were analyzed 24 h after the last exposure for pulmonary inflammation, serum biomarkers and aorta mRNA markers of vascular disease. Measures of normal ventilatory function declined following each O₃ exposure in both adult and senescent rats, however, senescent rats took weeks to exhibit a decline. Evidence for residual respiratory effects of O₃ 7 d after exposure in both age groups was observed. O₃ had no effect on either heart rate or blood pressure, but decreased motor activity in both age groups. BALF indicated mild neutrophilic inflammation and protein leakage in adults. Age affected 17/58 serum analytes, O₃ affected 6/58; 2/58 showed an age-O₃ interaction. Leptin, adiponectin, lipocalin and insulin were increased in senescent rats. Overall, adult rats exhibited more immediate effects of episodic O₃ than senescent rats. Residual effects were, however, obtained in both ages of rat, especially for ventilatory endpoints.

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Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing

Koh

Kovalik

2021

ESC Heart Failure

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The purpose of this review is to explore how metabolomics can help uncover new biomarkers and mechanisms for cardiovascular ageing. Cardiovascular ageing refers to cardiovascular structural and functional alterations that occur with chronological ageing and that can lead to the development of cardiovascular disease. These alterations, which were previously only detectable on tissue histology or corroborated on blood samples, are now detectable with modern imaging techniques. Despite the emergence of powerful new imaging tools, clinical investigation into cardiovascular ageing is challenging because ageing is a life course phenomenon involving known and unknown risk factors that play out in a dynamic fashion. Metabolomic profiling measures large numbers of metabolites with diverse chemical properties. Metabolomics has the potential to capture changes in biochemistry brought about by pathophysiologic processes as well as by normal ageing. When combined with non-invasive cardiovascular imaging tools, metabolomics can be used to understand pathological consequences of cardiovascular ageing. This review will summarize previous metabolomics and imaging studies in cardiovascular ageing. These methods may be a clinically relevant and novel approach to identify mechanisms of cardiovascular ageing and formulate or personalize treatment strategies.

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Serum biomarkers of aging in the Brown Norway rat

Cited by 21 publications

References 18 publications

Age-Related Histological Changes in Kidneys of Brown Norway Rat

Age-Related Histological Changes in Kidneys of Brown Norway Rat

Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function

Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing

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