Serum biomarkers in normal pressure hydrocephalus

Abstract

<p><strong>Aim</strong> <br />To investigate the serum value of brain derived neurotrophic factor (BDNF), proteins S-100, NSE, IL-6 in normal pressure patients (NPH) compared to control (healthy) group and also a possible correlation with radiological findings in NPH patients.<br /><strong>Methods</strong> <br />Study patients were included during the period of 2020-2022. All NPH patients met the diagnostic criteria for probability<br />of NPH. Control patients group included patients without known brain disorder, without clinical symptoms of NPH. Blood samples were taken before planned surgery for NPH. BDNF serum concentrations were assessed by a sensitive ELISA kit, and serum concentrations of S-100, NSE and IL-6 were assessed by using ECLIA technology for immunoassay detection.<br /><strong>Results</strong> <br />Among 15 patients who were included, seven NPH patients were compared to eight control patients. Non-significant<br />decrease in BDNF serum concentrations, an increase of protein S-100 serum concentrations, a decrease of NSE serum concentrations, as well as an increase of IL-6 serum concentrations in NPH patients compared to healthy controls was found. Strong positive correlation between BNDF and Evans index was observed (p=0.0295).<br /><strong>Conclusion</strong> <br />We did not find a significant difference of BDNF, protein S-100, IL-6 and NSE between serum concentration in NPH<br />and healthy patients. More future research is needed to find the<br />role of BDNF in NPH patients.</p>