Serum biochemical markers of central nerve system damage in children with acute elemental mercury intoxicatıon

Yilmaz, Fatma Meriã; Yilmaz, Hınç; Tutkun, Engın; Uysal, Samiye; Çarman, Kürşat Bora; Dilber, Cengiz; Ercan, Müjgan

doi:10.3109/15563650.2013.860986

Cited by 21 publications

(13 citation statements)

References 32 publications

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“…Originated from the brain, NSE is a protein commonly used to assess the presence and severity of neurological injury. 35 Higher levels of serum NSE reported in patients with silicosis, 36 mercury intoxication, 37 pneumoconiosis, 38 and those exposed to chromium 9 and carbon-monoxide 39 . Lower levels of serum NSE were reported in workers exposed to organic solvents, 8 and patients with major depressive and bipolar affective disorders.…”

Section: Discussionmentioning

confidence: 99%

Serum Neuron-Specific Enolase, Biogenic Amino-Acids and Neurobehavioral Function in Lead-Exposed Workers from Lead-Acid Battery Manufacturing Process

Kalahasthi¹,

Barman²,

Rajmohan³

2015

Int J Occup Environ Med

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Section: Discussionmentioning

confidence: 99%

Serum Neuron-Specific Enolase, Biogenic Amino-Acids and Neurobehavioral Function in Lead-Exposed Workers from Lead-Acid Battery Manufacturing Process

Kalahasthi¹,

Barman²,

Rajmohan³

2015

Int J Occup Environ Med

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“…In another study GRIA1 levels were investigated in cases of mercury exposure and were found to be higher than in the control group. High levels of GRIA1 were related to improvement of the neurological symptoms of exposed patients and it was suggested as a potential neurological biomarker in mercury-induced neurotoxicity (15). On the other hand, no difference was found in terms of S100B and NSE levels between groups.…”

Section: Discussionmentioning

confidence: 92%

“…GRIA1 is responsible for glutamate-mediated excitation of neural cells and is important in memory formation and learning. GRIA1 levels were investigated in acute mercury intoxication and were suggested to be a potential neurological biomarker in mercury-induced neurotoxicity (15).…”

Section: Introductionmentioning

confidence: 99%

Serum S100B, NSE and GRIA Levels as Neurological Markers in Lead Exposure

2018

Turk J Med Sci

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Background/aim: The central nervous system is one of the major targets in lead exposure. Biomarkers for the diagnosis and follow-up of lead exposure have not been identified. In this study, serum S100B, neuron-specific enolase (NSE), and glutamate receptor 1 (GRIA1) levels were determined as possible biomarkers for lead neurotoxicity. Material and methods: Twenty-five subjects with chronic lead exposure and 25 controls were included in the study. NSE and S100B were measured by electrochemiluminescence immunoassay with a Cobas E601 analyzer. GRIA1 levels were measured with an ELISA kit using a quantitative sandwich enzyme immunoassay technique. Results: GRIA1 levels were significantly higher in the lead exposure group than in the control group. No significant differences for NSE, S100B, ALT, AST, or creatinine in sera were found between lead exposure and control groups. Conclusion: Subjects with chronic lead exposure are found to have increased glutamate receptor levels and do not seem to have glial or neuronal damage, which can be demonstrated with the elevation of NSE and S100B levels. GRIA1 levels might be used as a biomarker for the neurotoxicity of lead.

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“…Elemental mercury exposure occurs frequently and might cause neurological symptoms (5). Yilmaz et al (6) have shown that serum neuron-specific enolase (NSE), S100B and glutamate receptor have been found to be significantly higher in these patients with neurological symptoms. In our case, although the patient ingested a large dose of elemental mercury, there were no clinical symptoms present.…”

Section: Discussionmentioning

confidence: 99%