Serum Bilirubin Level Changes in Multiple Sclerosis Patients

Barzegar, Mahdi; Shaygannejad, Vahid; Mirmosayyeb, Omid; Valipour, Samane; Akbari, Roya; Vesal, Sahar; Ashtar, Fereshte; Dehghani, Leila; Mohammadi, Abdolrasoul; Esmaeil, Nafiseh

doi:10.29252/nirp.cjns.4.12.30

Cited by 1 publication

(1 citation statement)

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“…45 The possible causes of the bilirubin decline include its role as an endogenous antioxidant and neuroprotective agent, other reports found a lower level of Bilirubin in neurological diseases such as Multiple sclerosis and Acute Ischemic Stroke. 46,47 A defect in the blood-brain barrier (BBB) may be the cause of elevated albumin levels. it has been demonstrated that BBB dysfunction and subsequent serum albumin extravasation contribute to epileptogenesis and the pathophysiology of epilepsy.…”

Section: Resultsmentioning

confidence: 99%

Hydrogen Sulfide and Cystathionine γ–Lyase with Oxidants and Antioxidants Levels for Patients with Epilepsy Diseases

Al-Taee,

Al-Helaly

2024

Pharmacogn J.

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The research includes studying the levels of hydrogen sulphide (H 2 S) and cystathionine γ-lyase (CSE) with some oxidants and antioxidants in the serum of patients with epilepsy disease in Mosul city which include: malondialdehyde (MDA), peroxynitrite (ONOO-), glutathione (GSH), total bilirubin (TSB), albumin (Alb) and uric acid (UA), were measured in the patient group who suffered from epilepsy disease in Mosul city, Samples reached (116), which included: (56) samples for epilepsy patients group, and (60) for control group. The results showed there was a significant decrease in the levels of H2S, CSE, GSH, and TSB and a significant increase in the levels of MDA, ONOO-, Alb and UA in serum for epilepsy patients when Compared with the control group. The study concluded that H 2 S gas produced within the body and CSE suffer from low levels within the body, and they also decrease with the increase in the duration of the disease as a result of their use as protective functions in the body against epilepsy disease and developing it, by observing the levels of oxidants and antioxidants compounds and stimulating the body to increase their levels (H 2 S, and CSE) in various ways can lead to improving the health condition of patients.

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Section: Resultsmentioning

confidence: 99%