Serum bilirubin is inversely associated with insulin resistance and metabolic syndrome among children and adolescents

Biochemical Profile of Serbian Youth National Soccer Teams

“…Low total bilirubin levels may be related with dysregulation of insulin signaling (Lin et al, 2009). Results similar to ours have been reported by some authors (Banfi).…”

High sensitive c-reactive protein and serum amyloid a are inversely related to serum bilirubin: effect-modification by metabolic syndrome

“…Remarkably, effect modification of the relationship of SAA with bilirubin was observed in the context of MetS, T2DM and insulin resistance, despite expected robust correlations between hs-CRP and SAA levels, which were present in all subject categories. Lower bilirubin levels in MetS, and the inverse relationship of bilirubin with HOMA-IR extend other studies that reported on such inverse relationships of bilirubin with abdominal obesity [35], insulin resistance [36] and diabetes [3,37]. In a large Korean cohort, higher bilirubin levels were also found to be associated with a low prevalence of MetS [5].…”

Relationship Between Bilirubin Concentration, Coronary Endothelial Function, and Inflammatory Stress in Overweight Patients

“…Previous studies 7,33) demonstrated that serum total bilirubin was inversely associated with insulin resistance in children and adolescents with metabolic syndrome and in young adults, possibly via its anti-oxidative effect or via the effect of its metabolic pathway (biliverdin reductase cycle) on insulin signaling [34][35][36] . Giral et al 37) .…”

“…and attenuates insulin resistance in patients with metabolic syndrome 7) . Further, low serum concentrations of bilirubin are associated with endothelial dysfunction 6) and an increased risk of CHD 8,9) and metabolic syndrome 10,11) .…”