Serum bile acids associate with liver volume in polycystic liver disease and decrease upon treatment with lanreotide
Shosha E. I. Dekker,
Jörgen Bierau,
Martin Giera
et al.
Abstract:BackgroundPolycystic liver disease (PLD) is a common extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD). Bile acids may play a role in PLD pathogenesis. We performed a post‐hoc exploratory analysis of bile acids in ADPKD patients, who had participated in a trial on the effect of a somatostatin analogue. Our hypothesis was that serum bile acid levels increase in PLD, and that lanreotide, which reduces liver growth, may also reduce bile acid levels. Furthermore, in PLD, urinary excr… Show more
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