Serum betatrophin levels are significantly increased in obese patients compared to lean patients regardless to the presence of PCOS

Keyif, Betül; Çelik, Hale Göksever; Balcı, Burçin Karamustafaoğlu; Celebi, Merve Mehves; Ozaltin, Selin; Takmaz, Özgüç; Buyru, Faruk; Baştu, Ercan

doi:10.1080/09513590.2020.1725964

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Our findings accord with a previous study that reported a positive correlation between ANGPTL8 and TG, LDL, and IR levels and a negative correlation between ANGPTL8 and HDL levels. 30 These findings provide evidence that glycolipid metabolic abnormality, IR, and hyperandrogenism are key factors stimulating ANGPTL8 secretion and that ANGPTL8 upregulation further aggravates glycolipid metabolic disorders and IR.…”

Section: Discussionmentioning

confidence: 65%

Association Between rs2278426 Polymorphism of the ANGPTL8 Gene and Polycystic Ovary Syndrome

Wu,

Wang,

Sun

et al. 2024

DMSO

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To study the relationship between the single nucleotide polymorphism (SNP) rs2278426 in the angiopoietin-like protein 8 gene (ANGPTL8) and polycystic ovary syndrome (PCOS). Patients and methods: A total of 122 patients with PCOS and 108 controls were recruited for comparison of glucose, lipid, insulin, sex hormone, and ANGPTL8 levels. Polymerase chain reaction (PCR) and gene sequencing were performed for comparison of the frequency of the CC, CT, and TT rs2278426 genotypes and the rs2278426 allele distributions between the PCOS and control groups and between the obese and non-obese subgroups of the PCOS and control groups. Results: The frequency of the T allele was significantly higher in the PCOS group than that in the controls (P = 0.037). In the dominant genetic model, the proportion of the CT+TT genotype in the PCOS group was significantly higher than that in the controls (P = 0.047). Subgroup analysis demonstrated that the T allele proportion was significantly higher in obese PCOS group than obese control group (P = 0.027). PCOS with the CT+TT genotype had significantly higher body mass index (BMI; P = 0.001), triglyceride (TG; P = 0.005), homeostasis model assessment of insulin resistance (HOMA-IR; P = 0.035), testosterone (P = 0.041), and ANGPTL8 (P = 0.037) levels and significantly lower high-density lipoprotein (HDL) levels (P = 0.025) than PCOS with the CC genotype. Obese PCOS group with the CT+TT genotype had significantly higher TG (P = 0.015), luteinizing hormone (LH; P = 0.030), fasting insulin (FINS; P = 0.039), HOMA-IR (P = 0.018), and ANGPTL8 (P = 0.049) levels than obese PCOS group with the CC genotype. Conclusion: Polymorphisms of rs2278426 may induce glycolipid metabolic disorders by affecting ANGPTL8 levels and functions in Han Chinese females with obesity from the Shandong region, increasing the risk of PCOS in this population.

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Section: Discussionmentioning

confidence: 65%

Association Between rs2278426 Polymorphism of the ANGPTL8 Gene and Polycystic Ovary Syndrome

Wu,

Wang,

Sun

et al. 2024

DMSO

View full text Add to dashboard Cite

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“…In contrast, another study disclosed that betatrophin levels were comparable in obese and insulin-resistant as well as in non-obese subjects ( Battal et al, 2018 ), while another study indicated that betatrophin levels in obese were higher than in non-obese people ( Abu-Farha et al, 2016 ). The serum levels of ANGPTL8/betatrophin/lipasin are significantly increased in obese patients compared to lean individuals independently to the present of polycystic ovary syndrome ( Keyif et al, 2020 ). Furthermore, other studies portrayed that betatrophin increases in both overweight and obese subjects ( Fu et al, 2014 , Borniger et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Dynamic alteration of plasma levels of betatrophin in younger female onset obesity post acute moderate-intensity exercise training

Susanto

Sugiharto

Taufiq

et al. 2023

Saudi Journal of Biological Sciences

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Investigation the role of vaspin and some hormones in pathogenicity of polycystic ovary syndrome in Diyala Province

Hasan¹,

Sahab²

2023

2nd International Conference on Mathematical Techniques and Applications: Icmta2021

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Serum betatrophin levels are significantly increased in obese patients compared to lean patients regardless to the presence of PCOS

Cited by 3 publications

References 23 publications

Association Between rs2278426 Polymorphism of the ANGPTL8 Gene and Polycystic Ovary Syndrome

Association Between rs2278426 Polymorphism of the ANGPTL8 Gene and Polycystic Ovary Syndrome

Dynamic alteration of plasma levels of betatrophin in younger female onset obesity post acute moderate-intensity exercise training

Investigation the role of vaspin and some hormones in pathogenicity of polycystic ovary syndrome in Diyala Province

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