Serum Beta-Trace Protein and Cystatin C as Biomarkers for Renal Dysfunction in Patients with Chronic Kidney Disease

El‐Aarag, Bishoy; Abdu-Allah, Azza M; Abo-Alfa, Mohamed Aid; Sayed, Ibrahim El Tantawy El

doi:10.4172/2155-9929.1000399

Cited by 2 publications

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“…Via the glomerular basement membrane, it is freely filtered and almost entirely excreted by the kidneys. Because of its low molecular mass, steady rate of production and stability, BTP has been proposed as a new endogenous glomerular filtration rate marker, and serum BTP levels have been estimated in patients with various stages of CKDs [10].…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and the risk of kidney diseases: the impact of life style modification

et al. 2021

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Background:The relationship between metabolic syndrome (MetS) and chronic kidney diseases (CKDs) is complex and bidirectional. However, the etiological role of MetS in CKDs is less clear. Objective: To assess the impact of the MetS on the kidney function using new renal biomarkers, and to study the effect of lifestyle modification by following a balanced hypocaloric diet and increasing physical activity. Subjects and Methods: Eighty seven obese women were enrolled in this study. The MetS criteria were studied which included from 0 to 5 components. Lifestyle changes were performed for eight weeks by following a low caloric balanced diet, and increasing their physical activity. Renal biomarkers were estimated before and after intervention. Results: About 65.5% of the obese volunteers were suffering from MetS, about 37% of them were complaining of renal symptoms. Higher consumption rate of high caloric diet and lower consumption rate of protein, vegetables and fruits were detected among obese metabolic patients compared to obese control. Improvement of all the MetS criteria and the biochemical renal markers were detected after intervention. Conclusion: The MetS raises the risk of CKDs. A change in the lifestyle, by including a low calorie healthy diet and increasing physical activity is necessary. Cystatin C/ Betatrace protein (Cys-C/ BTP) proved to be good promising biomarkers for detection of early changes in renal functions and defining better tools for prevention, early diagnosis and follow up.

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Section: Introductionmentioning

confidence: 99%