Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis

Karantali, Eleni; Kazis, Dimitrios; Papavasileiou, Vasileios; Prevezianou, Angeliki; Chatzikonstantinou, Symela; Petridis, Foivos; McKenna, John F.; Luca, Alina-Costina; Truş, Constantin; Ciobîcă, Alin; Mavroudis, Ioannis

doi:10.3390/medicina57030297

Cited by 36 publications

(28 citation statements)

References 45 publications

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“…Interestingly, it is also lower in patients with post-stroke depression compared to PwS without depression. These results are compatible with the hypothesis that a lower level of BDNF is associated with the pathogenesis of neural loss in several neuropsychiatric disorders and cognitive deficits [ 12 , 86 – 91 ]. Although the severity and type of stroke, either ischemic or hemorrhagic, can possibly correlate with the BDNF level as addressed by Chaturvedi et al [ 82 ], the lack of reporting data from the included studies prohibited us from further regression analysis of these influential factors.…”

Section: Discussionsupporting

confidence: 91%

“…Many studies have focused on the alternation of the peripheral BDNF level in different situations and reported BDNF changes in neurodegenerative disorders, brain insults, and psychiatric disorders [ 12 , 89 – 91 , 93 ]. Stroke as the second leading cause of death and morbidity worldwide is investigated remarkably, specifically in regards to post-stroke recovery measures.…”

Section: Discussionmentioning

confidence: 99%

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Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis

et al. 2022

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Background Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. The adaptation and reorganization process following any neuronal damage is regarded as neuroplasticity. Among many factors believed to attribute to this process, Brain-derived Neurotrophic Factor (BDNF) is a neurotrophin coordinating neuroplasticity after various neurological disorders such as stroke. Methods We conducted a systematic search in the main electronic medical databases in January 2021. Primarily we want to compare BDNF levels between patients with stroke and healthy controls (HC). Additional aims included investigation of (1) longitudinal changes in the BDNF levels post-stroke, (2) effects of physical training, (3) repeated transcranial magnetic stimulation (rTMS), and presence of depression on BDNF levels in patients with stroke. Results Among 6243 reviewed records from PubMed, Web of Science, and Scopus, 62 studies were eligible for inclusion in our systematic review. Subjects with stroke, n = 1856, showed lower BDNF levels compared to HC, n = 1191 (SMD [95%CI] = − 1.04 [− 1.49 to − 0.58]). No significant difference was detected in the level of BDNF through time points past stroke. BDNF levels were lower in the patients with depression compared to non-depressed subjects (SMD [95%CI] = − 0.60 [− 1.10 to − 0.10]). Physical training had an immediate positive effect on the BDNF levels and not statistically significant effect in the long term; SMD [95%CI] = 0.49 [0.09 to 0.88]) and SMD [95%CI] = 0.02 [− 0.43 to 0.47]). Lastly, rTMS showed no effect on the level of BDNF with 0.00 SMD. Conclusions Our study confirms that stroke significantly decreases the level of BDNF in various domains such as cognition, affect, and motor function. As BDNF is the major representative of neuroplasticity within nervous system, it is believed that stroke has a significant impact on the CNS regeneration, which is permanent if left untreated. This effect is intensified with coexisting conditions such as depression which further decrease the BDNF level but the net impact yet needs to be discovered. We also conclude that exercise and some interventions such as different medications could effectively reverse the damage but further studies are crucial to reach the exact modality and dosage for their optimal effect.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis

et al. 2022

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“…Interestingly, it is also lower in patients with post-stroke depression compared to PwS without depression. These results are compatible with the hypothesis that a lower level of BDNF is associated with the pathogenesis of neural loss in several neuropsychiatric disorders and cognitive de cits (15,(92)(93)(94)(95)(96)(97). In addition, our analysis also con rmed a positive effect of physical training, regardless of performing exercise or routine physiotherapy or rehabilitation, on the BDNF level immediately after the intervention.…”

Section: Discussionsupporting

confidence: 90%

“…Many studies have focused on the alternation of the BDNF level in different situations and reported BDNF changes in neurodegenerative disorders, brain insults, and psychiatric disorders (15,(95)(96)(97)99). Stroke as the second leading cause of death and morbidity worldwide is investigated remarkably, speci cally in regards to post-stroke recovery measures.…”

Section: Discussionmentioning

confidence: 99%

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

Mojtabavi

Shaka²,

Momtazmanesh³

et al. 2021

Preprint

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Background Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. Neuroplasticity is adaptation and reorganization following neuronal damage. Brain-derived neurotrophic factor (BDNF) is a neurotrophin coordinating neuroplasticity after various neurological disorders such as stroke. Methods We conducted a systematic search in the main electronic medical databases through January 2021 and identified studies that measured blood levels of BDNF in patients with stroke. The primary aim was to compare BDNF levels between patients with stroke and healthy controls (HC). The secondary aims included investigation of (1) longitudinal changes in the BDNF levels post-stroke, (2) effects of physical training, (3) repeated transcranial magnetic stimulation (rTMS), and presence of depression on BDNF levels in patients with stroke. Results Among 6243 reviewed records from PubMed, Web of Science, and Scopus, 62 studies were eligible for inclusion. Subjects with stroke, n = 1856, showed lower BDNF levels compared to HC, n=1191 (SMD [95%CI] = -1.04 [-1.49 to -0.58]). No significant difference was detected in the level of BDNF through time points past stroke. BDNF levels were lower in the patients with depression compared to non-depressed subjects (SMD [95%CI] = -0.60 [-1.10 to -0.10]). Physical training had an immediate positive effect on the BDNF levels and not statistically significant effect in the long term; SMD [95%CI] = 0.49 [0.09 to 0.88]) and SMD [95%CI] = 0.02 [-0.43 to 0.47]). Lastly, rTMS showed no effect on the level of BDNF with 0.00 SMD. Conclusions This study confirms that stroke significantly affects the level of BDNF in various domains such as cognition, affect, and motor function. We believe that BDNF could be regarded as a valuable diagnostic biomarker for acute stroke and a potential prognostic biomarker for depression and cognitive deficits.

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“…В метаанализе 26 научных работ, посвященных изучению уровня BDNF у пациентов в остром периоде инсульта (Karantali Е. et. al., 2021) [7], отмечена обратная корреляционная зависимость уровня BDNF в сыворотке крови и выраженности неврологического дефицита по шкале NIHSS. В то же время не наблюдалось корреляционных связей между уровнем BDNF и степенью функционального восстановления пациентов.…”

Section: результаты исследования и их обсуждениеunclassified

The role of neurotrophic proteins as prognostic markers of neurological, functional and cognitive impairments in the acute period of cerebral infarction in patients with sleep apnea

Сереброва¹,

Усова²

2021

Humans and their Health

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The objective: to evaluate the diagnostic efficacy of neurotrophic proteins BDNF, NGF, NT3 as prognostic markers of neurological, functional and cognitive impairments in the acute period of cerebral infarction in patients with and without sleep apnea. Materials and methods. 52 patients were examined in the first 72 hours from the onset of cerebral infarction (CI). The survey included an assessment on the NIHSS, mRs and MOSA scales (in the first 72 hours and after a month); study of the concentration of proteins BDNF, NGF, NT3 in plasma by enzyme immunoassay and respiratory polygraphy. The patients were divided into the main group (32 patients with sleep apnea (SA)) and the comparison group (20 patients without SA). The control group consisted of 32 patients without CI and SA. Results. In patients of main group at the end of the acute period of CI threshold concentrations of BDNF ≤1605.2 pg/ml (AUC - 80%), NGF ≤697.37 pg/ml (AUC - 78%) and NT3 ≤400.7 pg/ml (AUC - 70%) were established as effective prognostic markers of an unfavorable functional outcome (MRs≥3); BDNF ≤1994.8 pg/ml (AUC - 75%) - of severe neurological deficit (NIHSS> 4); BDNF ≤1724.7 pg/ml (AUC - 76%) and NGF ≤858.55 pg/ml (AUC - 73%) - of the presence of cognitive impairments (MOCA <26). In patients of the comparison group the threshold concentration of BDNF protein ≤1189.6 pg/ml was established as an effective prognostic marker of unfavorable functional outcome (AUC - 85%) and severe neurological deficit (AUC - 80%). Conclusion. Neurotrophic proteins have good indicators of diagnostic accuracy as prognostic markers of neurological, functional, and cognitive impairments at the end of the acute period of CI in patients with and without SA.

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Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis

Cited by 36 publications

References 45 publications

Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis

Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

The role of neurotrophic proteins as prognostic markers of neurological, functional and cognitive impairments in the acute period of cerebral infarction in patients with sleep apnea

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