Serum BDNF levels, glycolipid metabolism in deficit schizophrenia: A case-control study

Zhu, Xu; Chen, Dachun; Xiu, Meihong; Shen, Li; Zhang, Xiang Yang

doi:10.1016/j.ajp.2022.103003

Cited by 4 publications

(4 citation statements)

References 57 publications

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“…On the other hand, antioxidant defenses and innate immune system defenses against inflammation and bacterial infections are decreased in deficit schizophrenia, including sulfhydryl groups, total radical antioxidant trapping parameter (of plasma), paraoxonase 1 (PON1) activity, IgM responses to a variety of oxidative specific epitopes and TRYCATs [ 65 ]. Additionally, neuroprotective compounds including brain-derived neurotrophic factor (BDNF) are decreased in deficit schizophrenia [ 66 ]. Interactions between activated immune-inflammatory pathways and lowered BDNF may play a key role in schizophrenia [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

In Schizophrenia, the Effects of the IL-6/IL-23/Th17 Axis on Health-Related Quality of Life and Disabilities Are Partly Mediated by Generalized Cognitive Decline and the Symptomatome

Al-Musawi

Al‐Hakeim

Al-Khfaji

et al. 2022

IJERPH

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Schizophrenia patients show increased disabilities and lower quality of life (DisQoL). Nevertheless, there are no data on whether the activation of the interleukin (IL)-6, IL-23, T helper (Th)-17 axis, and lower magnesium and calcium levels impact DisQoL scores. This study recruited 90 patients with schizophrenia (including 40 with deficit schizophrenia) and 40 healthy controls and assessed the World Health Association QoL instrument-Abbreviated version and Sheehan Disability scale, Brief Assessment of Cognition in Schizophrenia (BACS), IL-6, IL-23, IL-17, IL-21, IL-22, tumor necrosis factor (TNF)-α, magnesium and calcium. Regression analyses showed that a large part of the first factor extracted from the physical, psychological, social and environmental HR-QoL and interference with school/work, social life, and home responsibilities was predicted by a generalized cognitive deterioration (G-CoDe) index (a latent vector extracted from BACs scores), and the first vector extracted from various symptom domains (“symptomatome”), whereas the biomarkers had no effects. Partial Least Squares analysis showed that the IL6IL23Th17 axis and magnesium/calcium had highly significant total (indirect + direct) effects on HR-QoL/disabilities, which were mediated by G-CoDe and the symptomatome (a first factor extracted from negative and positive symptoms). The IL6IL23Th17 axis explained 63.1% of the variance in the behavioral-cognitive-psycho-social (BCPS) worsening index a single latent trait extracted from G-CoDe, symptomatome, HR-QoL and disability data. In summary, the BCPS worsening index is partly caused by the neuroimmunotoxic effects of the IL6IL23Th17 axis in subjects with lowered antioxidant defenses (magnesium and calcium), thereby probably damaging the neuronal circuits that may underpin deficit schizophrenia.

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Section: Discussionmentioning

confidence: 99%

In Schizophrenia, the Effects of the IL-6/IL-23/Th17 Axis on Health-Related Quality of Life and Disabilities Are Partly Mediated by Generalized Cognitive Decline and the Symptomatome

Al-Musawi

Al‐Hakeim

Al-Khfaji

et al. 2022

IJERPH

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“…A metaanalysis from 2019 proved that lower levels of BDNF are related to the reduction of cognitive function in patients with chronic schizophrenia [32]. Moreover, BDNF levels are higher in patients with non-deficit schizophrenia, which can be related to its neuroprotective effects [33]. It was reported that higher BDNF expression correlates with better problem-solving abilities among patients [34].…”

Section: Bdnf In Schizophreniamentioning

confidence: 99%

“…Some researchers proposed using serum BDNF level as a biomarker of the course and management of the disease. The majority of studies suggested that lower levels of BDNF relate to more severe symptoms [33,46,47]. It was reported that repeated BDNF serum level assessment can be useful in monitoring the effectiveness of neurorehabilitation, which improves social functioning among patients [48], whereas baseline values of BDNF can be valuable to assess the severity of negative schizophrenia symptoms; however, they are not associated with the risk of relapse [49,50].…”

Section: Bdnf In Schizophreniamentioning

confidence: 99%

Neuroprotective factors in schizophrenia: BDNF, NGF, NT3, GDNF and their connection to the pathogenesis of schizophrenia. A narrative review

Sikorski

SIKORSKA²,

Michalska

et al. 2023

Curr Probl Psychiatry

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Introduction: There are several hypotheses of schizophrenia pathogenesis, including the neurodegenerative theory, which is supported by evidence for the decrease of neuroprotective factors’ serum levels. The proteins, that exert a protective effect on neurons and are researched concerning schizophrenia pathogenesis, include the brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin 3 (NT3), and glial cell line-derived neurotrophic factor (GDNF). This review aims to discuss the role of neuroprotective factors in the development of schizophrenia and their relevance in clinical trials. Material and methods: This review was performed by search of the PubMed, Google Scholar, and Science Direct databases from December 25th, 2022, through January 31st, 2023, using keywords: ‘schizophrenia’, ‘schizophrenia pathogenesis’, ‘neuroprotection’, ‘neurodegeneration’, ‘BDNF’, ‘NGF’, ‘NT3’, and ‘GDNF’. We considered original research papers and systematic reviews published in English or Polish. Additionally, clinical trials, which included the assessment of neuroprotective factors’ levels in schizophrenia as outcome measures, were searched for on clinicaltrials.gov. Results: Lower levels of serum BDNF have been linked to cognitive impairment in schizophrenia. In clinical trials, the assessment of serum BDNF is used as a clinical outcome measure for novel schizophrenia therapies. Schizophrenia has also been associated with reduced peripheral NGF levels. During remission, lower NGF levels correlate with higher severity of negative symptoms. Decreased NT3 and GDNF levels can also be seen, but literature reports are inconsistent. Conclusions: Neuroprotective factors are most likely related to the pathogenesis of schizophrenia. Assessing the serum level of these proteins may prove to be an invaluable element of schizophrenia management. Keywords: schizophrenia, brain-derived neurotrophic factor, nerve growth factor,neurotrophin 3, glial cell line-derived neurotrophic factor

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“…Therefore, it is important to increase our understanding of the risk factors for GLMD during childhood and adolescence. Previous studies have illustrated that risk factors for GLMD in children include unhealthy dietary habits[ 2 ], genetic factors[ 3 , 4 ], poor prenatal exposure to high maternal fasting blood glucose (FBG) levels[ 5 ], and gestational diabetes. Overall, conclusions about insulin resistance (IR) and quality of life (QoL) are controversial.…”

Section: Introductionmentioning

confidence: 99%

Relationship between quality of life and adolescent glycolipid metabolism disorder: A cohort study

Liang

Ren

Liang

et al. 2022

WJD

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BACKGROUND The prevalence of glucolipid metabolic disorders (GLMDs) in children and adolescents has a recognized association with cardiovascular diseases and type 2 diabetes mellitus in adulthood. Therefore, it is important to enhance our under-standing of the risk factors for GLMD in childhood and adolescence. AIM To explore the relationship between quality of life (QoL) and adolescent GLMD. METHODS This study included 1956 samples in 2019 from a cohort study established in 2014. The QoL scale and glycolipid indexes were collected during follow-up; other covariates of perinatal factors, physical measures, and socioeconomic indicators were collected and adjusted. A generalized linear regression model and logistic regression model were used to analyse the correlation between QoL and GLMD. RESULTS Higher scores of QoL activity opportunity, learning ability and attitude, attitude towards doing homework, and living convenience domains correlated negatively with insulin and homeostasis model assessment insulin resistance (IR) levels. Psychosocial factors, QoL satisfaction factors, and total QoL scores had significant protective effects on insulin and IR levels. Activity opportunity, learning ability and attitude, attitude towards doing homework domains of QoL, psychosocial factor, and total score of QoL correlated positively with high density lipoprotein. In addition, the attitude towards doing homework domain was a protective factor for dyslipidaemia, IR > 3, and increased fasting blood glucose; four factors, QoL and total QoL score correlated significantly negatively with IR > 3. In subgroup analyses of sex, more domains of QoL correlated with insulin and triglyceride levels, dyslipidaemia, and IR > 3 in females. Poor QoL was associated with an increased prevalence of GLMD, and the effect was more pronounced in males than in females. Measures to improve the QoL of adolescents are essential to reduce rates of GLMD. CONCLUSION Our study revealed that QoL scores mainly correlate negatively with the prevalence of GLMD in adolescents of the healthy population. The independent relationship between QoL and GLMD can be illustrated by adjusting for multiple covariates that may be associated with glycaemic index. In addition, among females, more QoL domains are associated with glycaemic index.

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Serum BDNF levels, glycolipid metabolism in deficit schizophrenia: A case-control study

Cited by 4 publications

References 57 publications

In Schizophrenia, the Effects of the IL-6/IL-23/Th17 Axis on Health-Related Quality of Life and Disabilities Are Partly Mediated by Generalized Cognitive Decline and the Symptomatome

In Schizophrenia, the Effects of the IL-6/IL-23/Th17 Axis on Health-Related Quality of Life and Disabilities Are Partly Mediated by Generalized Cognitive Decline and the Symptomatome

Neuroprotective factors in schizophrenia: BDNF, NGF, NT3, GDNF and their connection to the pathogenesis of schizophrenia. A narrative review

Relationship between quality of life and adolescent glycolipid metabolism disorder: A cohort study

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