Serum autoantibodies in silicosis and non‐silicosis cement workers

Beshir, Safia; Shaheen, Weam; Elserougy, Safaa; Aziz, Hisham M.

doi:10.1002/ajim.22413

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Silicosis is characterized in part by elevations in serum and bronchoalveolar lavage immunoglobulins in silicosis patients [46,47] and experimentally exposed animals [20]. Another well-known health outcome associated with silica exposure is an increase in the incidence of autoimmune disorders [48,49] including rheumatoid arthritis [50], scleroderma [51], systemic lupus erythematosus [52], and antineutrophilic cytoplasmic antibody-related nephritis [53].…”

Section: Discussionmentioning

confidence: 99%

Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions

Shimada

Kohara

Naota

et al. 2016

Folia Histochem Cytobiol.

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Introduction. Exposure to Asian sand dust (ASD) is associated with enhanced pulmonary morbidity and mortality, and the reporting of such cases has rapidly increased in East Asia since 2000. The purpose of the study was to assess chronic lung toxicity induced by ASD. Material and methods. A total of 174 ICR mice were randomly divided into 5 control and 17 exposure groups. Suspensions of low dose (0.2, 0.4 mg) and high dose (3.0 mg) of ASD particles in saline were intratracheally instilled into ICR mice, followed by sacrifice at 24 hours, 1 week, and 1, 2, 3 and 4 months after instillation. Paraffin sections of lung tissues were stained with hematoxylin and eosin and by immunohistochemistry to detect a-smooth muscle actin, collagen III, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), CD3, CD20, immunoglobulin G, interleukin-1b and inducible nitric oxide synthase. Results. A lung histological examination revealed similar patterns in the lesions of the groups treated with high (3.0 mg) or low dose (0.4 mg) of ASD. Acute inflammation was observed 24 h after treatment and subsided after 1 week; persistent granulomatous changes were observed at 2 months, focal lymphocytic infiltration at 3 months, and granuloma formation at 4 months. An increase in the size of granulomatous lesions was observed over time and was accompanied by collagen deposition in the lesions. The cytoplasm of macrophages in inflammatory lesions showed positive immunolabeling for MMP-9 at 24 h, 1 and 2 months after instillation of 3.0 mg of ASD. Positive immunolabeling for TIMP-1 was demonstrated in the cytoplasm of macrophages at 2 and 4 months after instillation of 3.0 mg of ASD. These findings suggest association between the expression of MMP-9 and TIMP-1 with the development of lung granulomatous lesions. Conclusions. These findings suggest that collagen deposition resulting from the altered regulation of extracellular matrix is associated with granuloma formation in the lungs of mice treated with ASD.

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Section: Discussionmentioning

confidence: 99%

Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions

Shimada

Kohara

Naota

et al. 2016

Folia Histochem Cytobiol.

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“…Our data showed that serum IgA concentration increased and IgM also elevated. Increasing of IgM was commonly reported in silicosis or silica dust contacted [ 24 – 26 ], so we speculated the discrepancy may be due to differences between coal mines and, thus, the coal dust composition or different genetic background [ 27 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis

et al. 2023

Journal of Immunology Research

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Evidence suggests that exposure to coal dust increases immunoglobulin concentration. However, there is a paucity of data reporting immunoglobulin G (IgG) subclass in coal workers’ pneumoconiosis (CWP). Therefore, this study intended to evaluate potential diagnostic biomarkers for the disease. CWP patients, dust-exposed workers without pneumoconiosis (DEW), and matched healthy controls (HCs) presented to the General Hospital of Datong Coal Mining Group and Occupational Disease Prevention and Treatment Hospital of Datong Coal Mining Group between May 2019 and September 2019 were recruited. The serum immunoglobulin concentration was determined by the multiplex immunoassay technique. Totally, 104 CWP patients, 109 DEWs, and 74 HCs were enrolled. Serum levels of IgG1, IgG2, IgM, and IgA were elevated in CWPs compared with those in DEWs and HCs ( P < 0.05 ). The order of diagnostic accuracy between CWPs and DEWs depicted by the receiver operating characteristic (ROC) curve was IgG2, IgM, IgG1, IgG3, and IgA. Significantly higher IgG1/IgG3 and IgG2/IgG3 ratios were observed in the CWP group than in DEW and HC groups. Based on the IgG2/IgG3 ratio, the area under the ROC curve between CWP and DEW was 0.785 (95% CI 0.723-0.838), with a sensitivity of 73.1% and a specificity of 73.4%. Our findings suggest that IgG1, IgG2, IgM, and IgA are higher in the CWPs than DEWs and HCs. The IgG2/IgG3 ratio provides a viable alternative for the diagnosis of CWP.

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“…Beshir et al revealed serum IgA mean level was significantly higher in the silicosis group compared to the non-silicosis group (315.1 AE 165.3 vs. 154.7 AE 105.1 mg/dl, respectively). 13 More interestingly, a recent study may explain the putative link between silicosis and IgA N, which is a NOD-like receptor, pyrin domain-containing 3 (NLRP3). In fact, NLRP3 are the key in the inflammatory process caused by silica: they are involved, in association with alveolar macrophages, in binding and eliminating crystalline silica particles, and thus leading to pulmonary fibrosis in recent studies.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Silicosis and IgA nephropathy, an exceptional association

et al. 2021

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A 57-year-old male who had been working in masonry for 33 years was hospitalized for renal function decline associated with exertional dyspnea. He presented with hypertension and limb edema. Urinalysis revealed an active urine sediment with glomerular proteinuria at 1.5 g/24h and the renal biopsy identified mesangial IgA Nephropathy. Chest tomography scans showed signs of silicosis. The patient received Angiotensin-Converting Enzyme Inhibitors with stable renal function. To our knowledge, the association of silicosis-IgA nephropathy has rarely been reported in the literature. This case highlights the effect of chronic exposure to silica dust and its association with both silica and renal disease.

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Serum autoantibodies in silicosis and non‐silicosis cement workers

Abstract: Serum IgA, ASMA, and anti-GBM are the principal immunologic parameters associated with silicosis.

Cited by 5 publications

References 33 publications

Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions

Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions

The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis

Case Report: Silicosis and IgA nephropathy, an exceptional association

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