Serum autoantibodies against epithelial cell adhesion molecules as disease biomarkers of eosinophilic esophagitis

Dellon, Evan S.; Lin, Lan; Beitia, Rose Mary; Moran, Timothy P.; Qian, Yuping

doi:10.1111/cea.13070

Cited by 10 publications

(6 citation statements)

References 11 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[112][113][114][115][116] Noninvasive markers have also been assessed in the blood, stool, and urine, though in general results have not been strong enough to be applied clinically. [117][118][119][120][121][122] Esophageal gene expression has also been assessed. The EoE Diagnostic Panel consists of a 94-gene signature that is strongly associated with a diagnosis of EoE, 123 can be assessed on a single biopsy, 124 and is responsive to successful treatment.…”

Section: Range Of Potential Outcomes In Eoementioning

confidence: 99%

A Conceptual Approach to Understanding Treatment Response in Eosinophilic Esophagitis

Dellon

Gupta

2019

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

Section: Range Of Potential Outcomes In Eoementioning

confidence: 99%

A Conceptual Approach to Understanding Treatment Response in Eosinophilic Esophagitis

Dellon

Gupta

2019

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

“…The characteristics of relevant but not included studies [ 18 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ] are reported in Table S1 ( ). Based on the ROBINS-I criteria [ 25 ], they were excluded due to serious or critical RoB in at least one domain, as shown in Table S2 ( ).…”

Section: Resultsmentioning

confidence: 99%

Allergy-Test-Based Elimination Diets for the Treatment of Eosinophilic Esophagitis: A Systematic Review of Their Efficacy

Pitsios

Vassilopoulou

Pantavou

et al. 2022

JCM

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disorder, linked with sensitization to food and airborne allergens. Dietary manipulations are proposed for the management of EoE inflammation and are often successful, confirming the etiological role of food allergens. Three different dietary approaches are widely used: the elemental, the empirical, and the allergy-test-driven approach. We performed a systematic review to assess the evidence on the association of allergens, detected by allergy tests, with clinically confirmed triggers of EoE. We systematically searched PubMed, Scopus, Embase, and the Cochrane Library, through 1 June 2021. We sought studies examining the correlation of skin-prick tests (SPT), atopy patch tests (APT), specific IgE, and serum-specific IgG4, with confirmed triggers of EoE. Data on the use of prick–prick tests were also extracted. Evidence was independently screened by two authors against predefined eligibility criteria. Risk of bias was assessed with the ROBINS-I tool. Of 52 potentially eligible studies, 16 studies fulfilling quality criteria were included. These studies used one to three different allergy tests detecting food sensitization. The positive predictive value was generally low to moderate but higher when a combination of tests was used than single-test evaluations. None of the selected studies used serum-specific IgG4. Although an extreme methodological variability was noticed in the studies, allergy-based elimination diets were estimated to be efficient in 66.7% of the cases. The efficacy of targeted elimination diets, guided by SPT, sIgE, and/or APT allergy tests, does not appear superior to empirical ones. In the future, tests using esophageal prick testing or ex vivo food antigen stimulation may prove more efficient to guide elimination diets.

show abstract

“…The association with autoimmunity is increasingly being investigated, as 6% of patients with EoE have concomitant psoriasis, psoriatic arthritis, rheumatoid arthritis, or Hashimoto's thyroiditis [33]. Indeed, antibodies against transmembrane desmoglein-3 (DSG3) and collagen XVII (NC16A) appeared to be increased in the sera of EoE patients [34].…”

Section: Genetic and Environmental Factors And Autoimmunitymentioning

confidence: 99%

Mechanistic Insights into Eosinophilic Esophagitis: Therapies Targeting Pathophysiological Mechanisms

Massironi,

Mulinacci,

Gallo

et al. 2023

Cells

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic predisposition (susceptibility loci), environmental triggers (allergens and dietary antigens), and a dysregulated immune response, mainly mediated by type 2 T helper cell (Th2)-released cytokines, such as interleukin (IL)-4, IL-5, and IL-13. These cytokines control eosinophil recruitment and activation as well as tissue remodeling, contributing to the characteristic features of EoE. The pathogenesis of EoE includes epithelial barrier dysfunction, mast cell activation, eosinophil degranulation, and fibrosis. Epithelial barrier dysfunction allows allergen penetration and promotes immune cell infiltration, thereby perpetuating the inflammatory response. Mast cells release proinflammatory mediators and promote eosinophil recruitment and the release of cytotoxic proteins and cytokines, causing tissue damage and remodeling. Prolonged inflammation can lead to fibrosis, resulting in long-term complications such as strictures and dysmotility. Current treatment options for EoE are limited and mainly focus on dietary changes, proton-pump inhibitors, and topical corticosteroids. Novel therapies targeting key inflammatory pathways, such as monoclonal antibodies against IL-4, IL-5, and IL-13, are emerging in clinical trials. A deeper understanding of the complex pathogenetic mechanisms behind EoE will contribute to the development of more effective and personalized therapeutic strategies.

show abstract

Serum autoantibodies against epithelial cell adhesion molecules as disease biomarkers of eosinophilic esophagitis

Cited by 10 publications

References 11 publications

A Conceptual Approach to Understanding Treatment Response in Eosinophilic Esophagitis

A Conceptual Approach to Understanding Treatment Response in Eosinophilic Esophagitis

Allergy-Test-Based Elimination Diets for the Treatment of Eosinophilic Esophagitis: A Systematic Review of Their Efficacy

Mechanistic Insights into Eosinophilic Esophagitis: Therapies Targeting Pathophysiological Mechanisms

Contact Info

Product

Resources

About