Serum Aspartate and Alanine Aminotransferase Activities in
Protein Energy Malnutrition

Osifo, Bola O.A.; Bolo-Deoku, J

doi:10.1159/000459115

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…A greater increase in ALT compared to AST has been shown to occur in association with the fatty liver of protein energy malnu trition [15]. No hypotheses were advanced by the authors as to why this should occur.…”

Section: Resultsmentioning

confidence: 99%

Serum Alanine Aminotransferase to Aspartate Aminotransferase Ratio and Degree of Fatty Liver in Morbidly Obese Patients

Nanji¹,

French²,

Freeman³

1986

Enzyme

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We evaluated the change in serum alanine aminotransferase (ALT; EC 2.6.1.2) to serum aspartate aminotransferase (AST; EC 2.6.1.1; ALT/AST) ratio with the degree of fatty liver in morbidly obese patients. A total of 31 patients were included in the study. Fatty liver was graded as 0 to 4+. The mean and SD of AST and ALT were not significantly different between groups of patients with various grades of fatty liver. There was, however, a significant correlation between the ALT/AST ratio and the degree of fatty infiltration of the liver. This, we believe, implies damage mainly to the plasma membrane allowing loss of cytoplasmic enzymes rather than loss of mitochrondrial enzymes.

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Section: Resultsmentioning

confidence: 99%

Serum Alanine Aminotransferase to Aspartate Aminotransferase Ratio and Degree of Fatty Liver in Morbidly Obese Patients

Nanji¹,

French²,

Freeman³

1986

Enzyme

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“…A previous study showed that elevated transaminase levels were observed in ~30% of patients with AN (3) and its histological findings were compatible with secondary NASH (4). Severe weight loss-associated fatty liver disease has also been observed in protein energy malnutrition (15) and postoperative jejunoileal bypass (16). …”

Section: Discussionmentioning

confidence: 99%

Effects of pioglitazone on nonalcoholic steatohepatitis in a patient with anorexia nervosa: A case report

Ohno

Nishigaki

Yamada

et al. 2014

Experimental and Therapeutic Medicine

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Diseases associated with metabolic syndromes are of major concern in developed countries. Nonalcoholic steatohepatitis (NASH) is one of the manifestations of metabolic syndrome in the liver. Previous studies have shown that NASH is also caused by malnutrition. In the present study, a case of malnutrition-associated NASH in a 66-year-old female with anorexia nervosa is reported. The patient had a body mass index (BMI) of only 11.1 kg/m2 and serum alanine aminotransferase levels of 1,495 IU/l. Steatohepatitis with fibrosis was confirmed by percutaneous liver needle biopsy. Total parenteral nutrition was conducted at first, followed by the administration of Stronger Neo-Minophagen C (a glycyrrhizin-containing preparation), ursodeoxycholic acid and prednisolone. The abnormal elevation of aminotransferase levels of the patient was prolonged and total bilirubin levels increased. Pioglitazone (15 mg/day), which has been identified to be effective for nonalcoholic steatohepatitis, was then administered. This resulted in marked reductions in aminotransferase and bilirubin levels within three months. Histological improvement of the liver was also confirmed by percutaneous liver needle biopsy after one year. The observations in the present case suggest that pioglitazone may be useful for the treatment of malnutrition-associated NASH.

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“…This obstacle could rapidly deplete muscle mass, strength, performance, and immune function, ultimately jeopardizing athletic pursuits (15). Osifo and Bolodeoku (1982) demonstrated in their study on dominant protein-malnourished children aged 1-8 years that the enzymatic activities of ALT and AST increased in cases of protein-energy malnutrition. They also showed that the levels of these enzymes decreased upon recovery(16).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Macronutrients and Energy Intake and Liver Serum Transaminase Levels in Elderly Athletes and Non-Athletes: Findings from the Neyshabur Longitudinal Study on Aging

Bilondi,

Arabi,

Mohammadzadeh

et al. 2024

Preprint

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Background: Evaluating liver health and influential factors is crucial in the elderly population. Lifestyle factors like nutrition and exercise may impact liver function. This study aimed to investigate the association between macronutrients and energy intake with serum levels of aminotransferases in elderly Iranian athletes and non-athletes. Methods: This cross-sectional study included 811 elderly participants (369 athletes, 442 non-athletes) from the Neyshabur Longitudinal Study on Aging (NeLSA). Dietary intake was evaluated using a food frequency questionnaire. Serum Alanine aminotransferase and aspartate aminotransferase levels were measured. Regression Analyzes evaluated the associations between macronutrient intake and liver enzymes, adjusting for potential confounding variables. Results: For elderly athletes, higher calorie intake (β=0.0020, 95% CI: 0.0006, 0.0035, p=0.005), protein intake (β=0.0549, 95% CI: 0.0143, 0.0955, p=0.008), and carbohydrate intake (β=0.0107, 95% CI: 0.0033, 0.0181, p=0.005) were significantly associated with increased ALT levels in adjusted models. Higher carbohydrate intake (β=0.0061, 95% CI: 0.0021, 0.0100, p=0.003) and calorie intake (β=0.0009, 95% CI: 0.0001, 0.0017, p=0.018) were also associated with a notable increase in AST levels in elderly athletes. For elderly non-athletes, only higher protein intake (β=0.0411, 95% CI: 0.0046, 0.0777, p=0.027) was significantly associated with increased ALT levels, while none of the nutritional factors were associated with a notable change in AST levels in adjusted models for non-athletes. Conclusions: This study found higher calorie, protein, and carbohydrate intake were associated with increased liver enzymes ALT and AST in elderly individuals, particularly athletes. For athletes, all three nutrients were linked to elevated ALT, while only carbohydrates and calories impacted AST. For non-athletes, only protein affected ALT. These findings suggest tailored nutritional strategies may be needed to preserve liver health in active aging populations.

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Serum Aspartate and Alanine Aminotransferase Activities in Protein Energy Malnutrition

Cited by 10 publications

References 4 publications

Serum Alanine Aminotransferase to Aspartate Aminotransferase Ratio and Degree of Fatty Liver in Morbidly Obese Patients

Serum Alanine Aminotransferase to Aspartate Aminotransferase Ratio and Degree of Fatty Liver in Morbidly Obese Patients

Effects of pioglitazone on nonalcoholic steatohepatitis in a patient with anorexia nervosa: A case report

Relationship between Macronutrients and Energy Intake and Liver Serum Transaminase Levels in Elderly Athletes and Non-Athletes: Findings from the Neyshabur Longitudinal Study on Aging

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