Serum Arsenic and Lipid Peroxidation Levels in Patients with Multiple Sclerosis

Abstract

Oxidative stress plays a crucial role in the pathogenesis of multiple sclerosis (MS). Previous studies have shown that oxidative stress is one of the main underlying mechanisms of arsenic-induced cellular damage. The aim of this study was to assess the serum levels of arsenic and its relationship with lipid peroxidation in MS patients from Tabriz, as the third polluted city of Iran. The study population included 38 MS female patients and 38 age-matched healthy controls. Serum malondialdehyde (MDA) and arsenic levels were measured using thiobarbituric acid reactive substances (TBARS) assay and electrothermal atomic absorption spectrometry, respectively. The results showed that the arsenic (P < 0.01) and MDA (P = 0.03) levels were significantly higher in patients with MS than those in control. Moreover, serum levels of arsenic and MDA were positively correlated in MS patients. The elevated levels of serum arsenic might explain the increased oxidative stress in MS patients. We suggest that high arsenic levels in serum may lead to MS development, and therefore, exposure to this metal should be limited.

Iron and copper in progressive demyelination – New lessons from Skogholt's disease

“…Progression of the disease seems to be influenced by oxidative stress, since the invasion of immune cells is accompanied by release of soluble factors including cytokines and ROS [59]. Several recent studies have reported peroxidative processes during the progression of MS [60][61][62], also in conjunction with metal exposure [63]. A presumption precipitating from the present and previous studies is that myelin is susceptible to ROS toxicity.…”

Protective role of eugenol on arsenic induced oxidative DNA damage and modulatory effect of GSTO2 polymorphism

“…There was considerably higher lipid peroxidation observed in arsenic (20.5 ± 0.31nM/Proteins(mg)) treated culture as compared to control (4.25 + 0.17nM/Proteins(mg)). Similarly in a study high lipid peroxidation levels were observed in serum of multiple sclerosis patients with high arsenic exposure from Tabriz, city of Iran (Yousefi, Ahmadi, Ghorbanihaghjo, Faghfoori, & Irannejad, ).…”

“…25 1 0.17 nM/Proteins(mg)). Similarly in a study high lipid peroxidation levels were observed in serum of multiple sclerosis patients with high arsenic exposure from Tabriz, city of Iran(Yousefi, Ahmadi, Ghorbanihaghjo, Faghfoori, & Irannejad, 2014).…”

Gas chromatography‐mass spectrometry based metabolomics profile of hippocampus and cerebellum in mice after chronic arsenic exposure

“…Though mechanism of MS is still in exploration, it is known characterized by progressive demyelination and neurodegeneration in CNS. Furthermore, a study suggested that high serum As level might exacerbate progress of MS . In term of these previous studies, cerebellar impairment caused by As exposure was confirmed, which might in relation to CNS neurodegeneration.…”