Serum Apo J as a potential marker of conversion from mild cognitive impairment to dementia

Romagnoli, Tommaso; Ortolani, Beatrice; Sanz, Jesús M.; Trentini, Alessandro; Seripa, Davide; Nora, Edoardo Dalla; Capatti, Eleonora; Cervellati, Carlo; Passaro, Angelina; Zuliani, Giovanni; Brombo, Gloria

doi:10.1016/j.jns.2021.117537

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…However, in contrast to their result, our findings revealed a significant association between CSF clusterin levels and executive function in the MCI population in cross-sectional. In a study of plasma clusterin levels, lower clusterin groups were also found to have lower cognitive scores, which was consistent with our findings ( Romagnoli et al, 2021 ).…”

Section: Discussionsupporting

confidence: 92%

Association between cerebrospinal fluid clusterin and biomarkers of Alzheimer’s disease pathology in mild cognitive impairment: a longitudinal cohort study

Wang,

Ma,

Sheng

et al. 2023

Front. Aging Neurosci.

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BackgroundClusterin, a glycoprotein implicated in Alzheimer’s disease (AD), remains unclear. The objective of this study was to analyze the effect of cerebrospinal fluid (CSF) clusterin in relation to AD biomarkers using a longitudinal cohort of non-demented individuals.MethodsWe gathered a sample comprising 86 individuals under cognition normal (CN) and 134 patients diagnosed with MCI via the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. To investigate the correlation of CSF clusterin with cognitive function and markers of key physiological changes, we employed multiple linear regression and mixed-effect models. We undertook a causal mediation analysis to inspect the mediating influence of CSF clusterin on cognitive abilities.ResultsPathological characteristics associated with baseline Aβ42, Tau, brain volume, exhibited a correlation with initial CSF clusterin in the general population, Specifically, these correlations were especially prominent in the MCI population; CSF Aβ42 (PCN = 0.001; PMCI = 0.007), T-tau (PCN < 0.001; PMCI < 0.001), and Mid temporal (PCN = 0.033; PMCI = 0.005). Baseline CSF clusterin level was predictive of measurable cognitive shifts in the MCI population, as indicated by MMSE (β = 0.202, p = 0.029), MEM (β = 0.186, p = 0.036), RAVLT immediate recall (β = 0.182, p = 0.038), and EF scores (β = 0.221, p = 0.013). In MCI population, the alterations in brain regions (17.87% of the total effect) mediated the effect of clusterin on cognition. It was found that variables such as age, gender, and presence of APOE ε4 carrier status, influenced some of these connections.ConclusionOur investigation underscored a correlation between CSF clusterin concentrations and pivotal AD indicators, while also highlighting clusterin’s potential role as a protective factor for cognitive abilities in MCI patients.

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Section: Discussionsupporting

confidence: 92%

Association between cerebrospinal fluid clusterin and biomarkers of Alzheimer’s disease pathology in mild cognitive impairment: a longitudinal cohort study

Wang,

Ma,

Sheng

et al. 2023

Front. Aging Neurosci.

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“…LPS is transported in blood by the Lipopolysaccharide Binding Protein (LBP) ( Opal et al, 1999 ), which transfers it to its receptor or into lipoproteins ( Levels et al, 2005 ). Apolipoproteins, natural components of lipoproteins, are related to inflammation ( Castellani et al, 1997 ; Berbée et al, 2005 ; Mousa et al, 2023 ) and cognition ( Lewis et al, 2010 ; Koch et al, 2018 ; Shi et al, 2020 ; Romagnoli et al, 2021 ), including APOE4 ( Kloske and Wilcock, 2020 ; Duro et al, 2022 ; Liu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Divergent Roles of APOAI and APOM in the Identification of Alcohol Use Disorder and Their Association With Inflammation and Cognitive Decline: A Pilot Study

Escudero,

López-Valencia,

Arias Horcajadas

et al. 2024

International Journal of Neuropsychopharmacology

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Background Alcohol Use Disorder (AUD) courses with inflammation and cognitive decline. Apolipoproteins have emerged as novel target compounds related to inflammatory processes and cognition. Methods A cross-sectional study was performed on abstinent AUD patients with at least one month of abstinence (n=33; 72.7% men) and healthy controls (n=34; 47.1% men). A battery of plasma apolipoproteins (APOAI, APOAII, APOB, APOCII, APOE, APOJ and APOM), plasma inflammatory markers (LPS, LBP), and their influence on cognition and presence of the disorder were investigated. Results Higher levels of plasma APOAI, APOB, APOE and APOJ, as well as the proinflammatory LPS, were observed in the AUD group, irrespective of sex, whereas APOM levels were lower versus controls. Hierarchical logistic regression analyses, adjusting for covariates (age, sex, education), associated APOM with the absence of cognitive impairment in AUD, and identified APOAI and APOM as strong predictors of the presence or absence of the disorder, respectively. APOAI and APOM did not correlate with alcohol abuse variables or liver status markers but they showed an opposite profile in their associations with LPS (positive for APOAI; negative for APOM) and cognition (negative for APOAI; positive for APOM) in the entire sample. Conclusions The HDL constituents APOAI and APOM were differentially regulated in the plasma of AUD subjects compared to controls, playing divergent roles in the disorder identification and associations with inflammation and cognitive decline.

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A new generation of AD biomarkers: 2019 to 2021

Hawksworth

Fernández

Gevaert

2022

Ageing Research Reviews

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Serum Apo J as a potential marker of conversion from mild cognitive impairment to dementia

Cited by 5 publications

References 40 publications

Association between cerebrospinal fluid clusterin and biomarkers of Alzheimer’s disease pathology in mild cognitive impairment: a longitudinal cohort study

Association between cerebrospinal fluid clusterin and biomarkers of Alzheimer’s disease pathology in mild cognitive impairment: a longitudinal cohort study

Divergent Roles of APOAI and APOM in the Identification of Alcohol Use Disorder and Their Association With Inflammation and Cognitive Decline: A Pilot Study

A new generation of AD biomarkers: 2019 to 2021

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