Serum Apelin 13 Levels in Patients With Pulmonary Embolism

Şen, Hadice Selimoğlu; Kaplan, İbrahim; Abakay, Özlem; Sezgı, Cengizhan; Yılmaz, Süreyya; Taylan, Mahşuk; Abakay, Abdurrahman; Tanrıkulu, Abdullah Çetin

doi:10.1177/1076029615572467

Cited by 10 publications

(11 citation statements)

References 29 publications

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“…Sensitivity was 92.7% and specificity was 96.7% (95% confidence interval: 0.939 to 0.995, area under ROC curve: 0.979, p<0.001) ( Figure 2). Recently, Sen et al found that serum apelin-13 level was significantly higher in the PTE group than in the control group (p<001) [24]. This result is similar to our study results.…”

Section: Discussionsupporting

confidence: 92%

Diagnostic value of serum apelin-13 in patients with pulmonary thromboembolism

Karataş¹

2018

Ann Clin Anal Med

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Aim: We aimed to investigate whether serum apelin-13 value could be a novel biomarker in the diagnosis of pulmonary thromboembolism (PTE). Material and Method: The study included 142 patients, 82 of which were diagnosed with PTE and 60 were control cases. Serum apelin-13 level was measured using venous blood samples with the ELISA kit. Results: The serum apelin level was 2219.4 ± 65.2 ng/mL in the PTE group and 1234.7 ± 35.5 ng/mL in the control group (p<0.05). Serum apelin-13 was 2495.8 ± 738.0 ng/mL in the DVT (+) group and 2118.0 ± 496.8 ng/mL in the DVT (-) group (p=0.009). The best cutoff value for apelin-13 in the control and PTE groups was determined as 1579 ng/mL. Sensitivity was 92.7% and specificity was 96.7% (95% confidence interval: 0.939 to 0.995, area under ROC curve: 0.979, p<0.001). Discussion: This study showed that serum apelin-13 value can be used as new diagnostic biomarker in patients with PTE. Apelin-13 value also elevates in patients with DVT (+). These results suggest that apelin-13 value may be used as a novel biomarker in the patients with acute PTE and DVT (+) in future practice.

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Section: Discussionsupporting

confidence: 92%

Diagnostic value of serum apelin-13 in patients with pulmonary thromboembolism

Karataş¹

2018

Ann Clin Anal Med

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“…These findings were concurrent with previous studies. [ 28–30 ] On the other hand, our study showed that the administration of PD markedly alleviated lung histopathological alterations, fiber formation, collagen deposition, and decreased elevated α‐SMA levels in MTX‐treated rats. As previously reported, [ 31 ] the current results confirmed the effect PD on reducing hydroxyproline.…”

Section: Discussionmentioning

confidence: 71%

Polydatin combats methotrexate‐induced pulmonary fibrosis in rats: Involvement of biochemical and histopathological assessment

Ali

Ahmed

El‐Raouf

et al. 2022

J Biochem & Molecular Tox

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Polydatin (PD) is a polyphenolic compound found naturally in many fruits such as grapes. It has anti‐oxidant and anti‐inflammatory activities that are of paramount importance for its pharmacological actions. This study aimed to explore possible protective effects of PD against methotrexate (MTX)‐induced pulmonary fibrosis in rats. A single oral dose of MTX (14 mg/kg) per week for 2 weeks caused a significant decrease in glutathione (GSH) content with a marked increase in transforming growth factor‐beta (TGF‐β), alpha‐smooth muscle actin (α‐SMA), pulmonary content of malondialdehyde (MDA), interleukin‐1β (IL‐1β), Hydroxyproline, tumor necrosis factor‐alpha (TNF‐α), and 8‐hydroxy‐2'‐deoxyguanosine (8‐OHdG) as compared with the control group. Contrarily, daily administration of PD (25, 50, and 100 mg/kg, p.o.) for 14 days concomitantly with MTX ameliorated MTX‐induced pulmonary fibrosis as indicated by mitigation of the previously mentioned biochemical parameters and histopathological changes in a dose‐dependent manner. In conclusion, the protective effect of PD against pulmonary fibrosis induced by MTX in rats might be attributed to its anti‐oxidant, anti‐inflammatory as well as anti‐fibrotic effects.

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“…However, further studies are required to test these hypotheses. Moreover, higher concentration of apelin (1-13) during severe pulmonary embolism [212], a common complication in COVID-19 and the major cause of death in the patients [213,214], might be suggested as a possible biomarker for diagnosis of the stages of the COVID-19 severity. Losses of taste and smell have also been listed as COVID-19 symptoms which might be due to accumulation of the dynorphin A (1-13).…”

Section: Discussionmentioning

confidence: 99%