Serum apelin-13 and risk of death following severe traumatic brain injury

Zhuang, Yao-Kun; Wang, Wenhua; Chen, Long; Lu, Wei; Xu, Minhui

doi:10.1016/j.cca.2021.01.014

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…Moreover, serum apelin-13 can serve as a prognostic biomarker to determine the severity of brain trauma. A study demonstrated that the serum concentration of apelin-13 was significantly lower in post-traumatic patients and correlated with trauma severity assessed alongside the Glasgow Coma Scale (GCS) [132].…”

Section: Apelinmentioning

confidence: 99%

The Role of Adipokines in the Pathologies of the Central Nervous System

Huber,

Szerenos,

Lewandowski

et al. 2023

IJMS

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Adipokines are protein hormones secreted by adipose tissue in response to disruptions in physiological homeostasis within the body’s systems. The regulatory functions of adipokines within the central nervous system (CNS) are multifaceted and intricate, and they have been identified in a number of pathologies. Therefore, specific adipokines have the potential to be used as biomarkers for screening purposes in neurological dysfunctions. The systematic review presented herein focuses on the analysis of the functions of various adipokines in the pathogenesis of CNS diseases. Thirteen proteins were selected for analysis through scientific databases. It was found that these proteins can be identified within the cerebrospinal fluid either by their ability to modify their molecular complex and cross the blood–brain barrier or by being endogenously produced within the CNS itself. As a result, this can correlate with their measurability during pathological processes, including Alzheimer’s disease, amyotrophic lateral sclerosis, multiple sclerosis, depression, or brain tumors.

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Section: Apelinmentioning

confidence: 99%

The Role of Adipokines in the Pathologies of the Central Nervous System

Huber,

Szerenos,

Lewandowski

et al. 2023

IJMS

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show abstract

“…A clinical study on 126 patients with severe TBI and 126 healthy controls found that lower serum level of apelin-13 in the patients correlated significantly with increased severity of TBI, and was an independent predictor of short-term mortality, indicating that serum apelin-13 is a promising prognostic biomarker for severe TBI ( Zhuang et al, 2021 ). The protective effects of apelin-13 in TBI are associated with inhibition of autophagy ( Bao et al, 2015 ), suppression of neuronal apoptosis through the GLP-1R/PI3K/Akt signaling ( Liu et al, 2019 ), and mitigation of blood-brain barrier (BBB) destruction and brain edema ( Bao et al, 2016a ).…”

Section: Apelin-13mentioning

confidence: 99%

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies

Chen

et al. 2022

Front. Pharmacol.

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The incidence of cerebral ischemia has increased in the past decades, and the high fatality and disability rates seriously affect human health. Apelin is a bioactive peptide and the ligand of the G protein-coupled receptor APJ. Both are ubiquitously expressed in the peripheral and central nervous systems, and regulate various physiological and pathological process in the cardiovascular, nervous and endocrine systems. Apelin-13 is one of the subtypes of apelin, and the apelin-13/APJ signaling pathway protects against cerebral ischemia by promoting angiogenesis, inhibiting excitotoxicity and stabilizing atherosclerotic plaques. In this review, we have discussed the role of apelin-13 in the regulation of cerebral ischemia and the underlying mechanisms, along with the therapeutic potential of the apelin-13/APJ signaling pathway in cerebral ischemia.

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“…Under severe traumatic brain injury (TBI), endogenous apelin-13 is depleted, and reduced serum apelin-13 concentration is negatively correlated with the disease and independently related to the mortality within 30 days [ 47 ]. The course of TBI can be divided into primary injury and secondary injury, and the changes of biomarkers and drug treatment are generally concentrated in the secondary injury stage.…”

Section: Apelin/apj System Inhibits Traumatic Brain Injurymentioning

confidence: 99%

“…In a series of cerebrovascular diseases, apelin has also demonstrated neuroprotective capabilities similar to those of biochemical experiments. Serum apelin-13 concentrations in patients with ischemic stroke are strongly associated with disability and mortality [ 47 ]. Patients with high apelin-13 levels had a lower incidence of stroke over one year [ 117 ].…”

Section: Clinical Application Of Apelin/apj System In Nervous Systemmentioning

confidence: 99%

Apelin/APJ system: an emerging therapeutic target for neurological diseases

Zhao

Chen

et al. 2022

Mol Biol Rep

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Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively expressed in various systems, especially the nervous system. This article reviews the role of apelin/APJ system in neurological diseases. In detail, apelin/APJ system can relieve acute brain injury including subarachnoid hemorrhage, traumatic brain injury, and ischemic stroke. Also, apelin/APJ system has therapeutic effects on chronic neurodegenerative disease models, involving the regulation of neurotrophic factors, neuroendocrine, oxidative stress, neuroinflammation, neuronal apoptosis, and autophagy. In addition, through different routes of administration, apelin/APJ system has a biphasic effect on depression, epilepsy, and pain. However, apelin/APJ system exacerbates the proliferation and invasion of glioblastoma. Thus, apelin/APJ system is expected to be a therapeutic target for the treatment of nervous system diseases.

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Serum apelin-13 and risk of death following severe traumatic brain injury

Cited by 9 publications

References 19 publications

The Role of Adipokines in the Pathologies of the Central Nervous System

The Role of Adipokines in the Pathologies of the Central Nervous System

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies

Apelin/APJ system: an emerging therapeutic target for neurological diseases

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