Serum antiphospholipid antibody levels as biomarkers for diagnosis of pulmonary tuberculosis patients

Takenami, Iukary; Oliveira, Carolina Camargo de; Petrilli, Jéssica Dias; Machado, Adriana Rodrigues; Riley, Lee W.; Arruda, Silvana Gonçalves Brito de

doi:10.5588/ijtld.17.0874

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…B and T cells with self-reactive antigen receptors are usually deleted during their development in order to avoid AIDs. On the contrary, innate-like B-1 cells in mice are positively selected for self-reactivity as long-lived, self-renewing B cells that generate most of the circulating natural IgM [82]. They respond to self-determinants, such as carbohydrates and glycolipids, and often cross-react with bacterial antigens.…”

Section: B-1 B Cells Produce Igm Antiphospholipid Antibodies Which Ha...mentioning

confidence: 99%

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Tuberculosis and Autoimmunity

2022

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Tuberculosis remains a common and dangerous chronic bacterial infection worldwide. It is long-established that pathogenesis of many autoimmune diseases is mainly promoted by inadequate immune responses to bacterial agents, among them Mycobacterium tuberculosis. Tuberculosis is a multifaceted process having many different outcomes and complications. Autoimmunity is one of the processes characteristic of tuberculosis; the presence of autoantibodies was documented by a large amount of evidence. The role of autoantibodies in pathogenesis of tuberculosis is not quite clear and widely disputed. They are regarded as: (1) a result of imbalanced immune response being reactive in nature, (2) a critical part of TB pathogenicity, (3) a beginning of autoimmune disease, (4) a protective mechanism helping to eliminate microbes and infected cells, and (5) playing dual role, pathogenic and protective. There is no single autoimmunity-mechanism development in tuberculosis; different pathways may be suggested. It may be excessive cell death and insufficient clearance of dead cells, impaired autophagy, enhanced activation of macrophages and dendritic cells, environmental influences such as vitamin D insufficiency, and genetic polymorphism, both of Mycobacterium tuberculosis and host.

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Section: B-1 B Cells Produce Igm Antiphospholipid Antibodies Which Ha...mentioning

confidence: 99%

“…Major stimulating B-1 B cells antigens are phospholipids [23]. IgM aPL antibodies have self-and polyreactive properties [82].…”

Section: B-1 B Cells Produce Igm Antiphospholipid Antibodies Which Ha...mentioning

confidence: 99%

Tuberculosis and Autoimmunity

2022

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“…In addition, aPE have recently been shown to be significantly elevated in patient with tuberculosis [6] as in mouse model [11]. To the best of our knowledge, no infections other than tuberculosis have been associated with aPE to date.…”

Section: Discussionmentioning

confidence: 94%

“…In Q fever, Coxiella burnetii infection, deep vein thrombosis is mediated by anti-cardiolipid (aCL) IgG [5]. In tuberculosis, a significant elevation of antiphospholipid (aPL) antibodies such as, aCl IgM and anti beta2-glycoprotein 1 (aB2GP1) IgM and IgG was reported, but the link with thrombosis was not established [6]. To the best of our knowledge, there is no evidence in the literature of the association between elevation of aPL and VTE during tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Thromboses in tuberculosis are linked to antiphosphatidylethanolamine antibodies levels: A cross-sectional study

Bessis

Bertin

Million

et al. 2019

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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“…Different anti-phospholipid antibodies have been reported during infections of important global pathogens such as Mycobacterium tuberculosis ( 65 ), HIV ( 66 ) and others such as hepatitis C, cytomegalovirus, varicella zoster, Epstein-Barr virus, adenovirus, and parvovirus B ( 67 , 68 ). Active tuberculosis has been associated with a range of autoantibodies including with high levels of anti-cardiolipin and other anti-phospholipid antibodies ( 65 , 69 ). Additionally, autoantibodies targeting RBC components have been reported to increase tuberculosis susceptibility in HIV patients through erythrophagocytosis ( 70 ), suggesting a pathogenic role for autoantibodies in co-infection scenarios.…”

Section: Lessons From Malaria Applied To Covid-19 and Other Infectionsmentioning

confidence: 99%

Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections

Rivera-Correa

Rodrı́guez

2022

Front. Immunol.

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Autoimmunity is a common phenomenon reported in many globally relevant infections, including malaria and COVID-19. These and other highly inflammatory diseases have been associated with the presence of autoantibodies. The role that these autoantibodies play during infection has been an emerging topic of interest. The vast numbers of studies reporting a range of autoantibodies targeting cellular antigens, such as dsDNA and lipids, but also immune molecules, such as cytokines, during malaria, COVID-19 and other infections, underscore the importance that autoimmunity can play during infection. During both malaria and COVID-19, the presence of autoantibodies has been correlated with associated pathologies such as malarial anemia and severe COVID-19. Additionally, high levels of Atypical/Autoimmune B cells (ABCs and atypical B cells) have been observed in both diseases. The growing literature of autoimmune B cells, age-associated B cells and atypical B cells in Systemic Lupus erythematosus (SLE) and other autoimmune disorders has identified recent mechanistic and cellular targets that could explain the development of autoantibodies during infection. These new findings establish a link between immune responses during infection and autoimmune disorders, highlighting shared mechanistic insights. In this review, we focus on the recent evidence of autoantibody generation during malaria and other infectious diseases and their potential pathological role, exploring possible mechanisms that may explain the development of autoimmunity during infections.

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Serum antiphospholipid antibody levels as biomarkers for diagnosis of pulmonary tuberculosis patients

Abstract: Our results suggest that the total IgG anti-CL level could be useful to complement conventional bacteriological tests for the rapid diagnosis of adult pulmonary TB.

Cited by 9 publications

References 17 publications

Tuberculosis and Autoimmunity

Tuberculosis and Autoimmunity

Thromboses in tuberculosis are linked to antiphosphatidylethanolamine antibodies levels: A cross-sectional study

Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections

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