Serum antioxidants and risk of rheumatoid arthritis.

Heliövaara, Markku; Knekt, Paul; K, Aho; Aaran, Ritva-Kaarina; Alfthan, Georg; Aromaa, Arpo

doi:10.1136/ard.53.1.51

Cited by 199 publications

(98 citation statements)

References 7 publications

(1 reference statement)

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“…There is widespread availability and interest in the use of antioxidant supplementation by patients with inflammatory arthritis, although proof of efficacy is modest. A traditional Mediterranean diet relatively high in antioxidants improved RA disease and functional status after 3 months compared with a standard 'Western' diet, although clinical improvement was not associated with any significant change in plasma levels of antioxidants (Heliovaara et al, 1994;Skoldstam et al, 2003). In a separate study of patients with RA, supplementation with the antioxidants vitamin A, E, and C increased plasma antioxidant levels with a corresponding decrease in MDA, a key marker of OS; however, a clinical response was not reported (Jaswal et al, 2003).…”

Section: Newer Experimental Therapies With Antioxidants Evaluated In Aamentioning

confidence: 99%

See 1 more Smart Citation

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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Section: Newer Experimental Therapies With Antioxidants Evaluated In Aamentioning

confidence: 99%

“…Free radicals from oxygen metabolism destroy antioxidant systems (Harris, 2003). Researchers such as Heliovaara et al (1994) have suggested that enzymatic and/or nonenzymatic antioxidant systems are impaired in RA. RA patients are therefore exposed to oxidant stress (Harris, 2003).…”

Section: Newer Experimental Therapies With Antioxidants Evaluated In Aamentioning

confidence: 99%

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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“…Decreased plasma levels of vitamin C may indicate a decrease in the antioxidant capacity of aqueous humour. Heliovarra et al (1994) found low levels of vitamin E, β-carotene and selenium to be associated with increased risk of rheumatoid arthritis. The number of different antioxidant components in serum and tissues makes it relatively difficult to measure each antioxidant component separately.…”

Section: Antioxidant Capacity Antioxidants Free Radicals Dogmentioning

confidence: 99%

Total Antioxidant Capacity (TAC) Values and Their Correlation with Individual Antioxidants in Healthy Beagles

Nemec¹,

Drobnič‐Košorok²,

Skitek³

et al. 2000

Acta Vet. Brno

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The paper aims to establish a range for serum Total Antioxidant Capacity (TAC) and to determine the correlation between TAC and some individual antioxidants (vitamin A and E, lipid standardised vitamin E [Vit E/LS/], β-carotene, total bilirubin and albumin) in a uniform population of beagle dogs. Emphasis was directed on their general health status to establish a basis for future investigation of the role of TAC in diseases of dogs as species most frequently studied in veterinary medicine. The animal body possesses a variety of protective antioxidant substances that act as a harmoniously and finely tuned mechanism to neutralise harmful oxidants. TAC measurements provide a tool for establishing links between antioxidant capacity and the risk of disease as well as for monitoring of antioxidant therapy. Serum samples of 19 healthy beagles were assayed for TAC on LP 700 photometer (Dr. Lange, Germany) with a commercially available TAS kit ("Total Antioxidant Status" -TAS; Randox, Crumlin, UK). TAS kit measures the capacity of all of the antioxidants present in serum or plasma sample. The assay is based on the suppression of the absorbance of the radical cation of 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonate) (ABTS •+ ) by antioxidants. Assay results are expressed as mmol/l of Trolox (6-hydroxy-2, 5, 7, -tetramethylchroman-2-carboxylic acid -a water-soluble analogue of α-tocopherol) equivalents. The range for TAC expressed as mean ± SD resulted in 1.08 ± 0.08 mmol/l. TAC correlated positively with albumin (r = 0.18), vitamin E (r=0.14) and Vit E (LS) (r = 0.20), and negatively with total bilirubin (r = -0.30), vitamin A (r = -0.15) and β-carotene (r = -0.13) although no significant correaltion has been found.

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“…In subjects with RA and SLE, lower blood levels of antioxidants and decreased antioxidant intake have been reported (15,16). In a case-control study nested within a Finnish cohort, 14 subjects who developed RA a median of 20 years later had lower total levels of blood antioxidants than did healthy matched controls (17). In a similar study in Maryland, 21 individuals who later developed RA and 6 who later developed SLE had contributed samples to a serum bank 2-15 years prior to disease onset.…”

mentioning

confidence: 99%

Antioxidant Intake and Risks of Rheumatoid Arthritis and Systemic Lupus Erythematosus in Women

Costenbader¹,

Kang²,

Karlson³

2010

American Journal of Epidemiology

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Antioxidants may protect against development of rheumatoid arthritis or systemic lupus erythematosus by combating oxidative stress. The authors identified and confirmed incident cases of rheumatoid arthritis and systemic lupus erythematosus among 184,643 US women followed in the Nurses' Health Study and Nurses' Health Study II cohorts in 1980-2004. Semiquantitative food frequency questionnaires assessed intakes of vitamins A, C, and E and a-carotene, b-carotene, b-cryptoxanthin, lycopene, lutein, and zeaxanthin from foods and supplements. The authors examined total antioxidant intake by calculating a ''ferric-reducing ability of plasma'' score, a new method for quantifying the total antioxidant effect of a food based on the reduction of ferric to ferrous iron by antioxidants. Cumulative updated total energy-adjusted dietary intakes were used. Associations between intake of each nutrient and incident rheumatoid arthritis and systemic lupus erythematosus were examined in age-adjusted and Cox proportional hazards models, adjusted for confounders. Results from the cohorts were pooled meta-analytically by using random-effects models. The authors identified 787 incident rheumatoid arthritis cases and 192 systemic lupus erythematosus cases for whom prospective dietary information was available. In these large, prospective cohorts of women, antioxidant intake was not associated with the risk of developing either rheumatoid arthritis or systemic lupus erythematosus.

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Serum antioxidants and risk of rheumatoid arthritis.

Abstract: Objectives-Oxygen free

Cited by 199 publications

References 7 publications

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Total Antioxidant Capacity (TAC) Values and Their Correlation with Individual Antioxidants in Healthy Beagles

Antioxidant Intake and Risks of Rheumatoid Arthritis and Systemic Lupus Erythematosus in Women

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