Serum antioxidant levels and nutritional status in early and advanced stage lung cancer patients

Klarod, Kultida; Hongsprabhas, Pranithi; Khampitak, Tueanjit; Wirasorn, Kosin; Kiertiburanakul, Sasisopin; Tangrassameeprasert, Roongpet; Daduang, Jureerut; Yongvanit, Puangrat; Boonsiri, Patcharee

doi:10.1016/j.nut.2010.12.019

Cited by 25 publications

(22 citation statements)

References 17 publications

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“…This finding is further corroborated by an earlier study where serum level of vitamin A (a group of organic compound including retinol) and E (a group of organic compound including tocopherol) was also found to be lower in cases as compared to controls where low serum level of these vitamins was associated with 10.9 times and 5.6 times increased risk for oral cancer (Lawal et al, 2012). Inverse association of retinol and α-tocopherol have also been reported in other cancers such as lung (Klarod et al, 2011), breast (Shim et al, 2012) and gastric cancer (Jenab et al, 2006). The protective effect exerted by retinol and α-tocopherol could be explained by their role as potent regulators of cellular activities, thus having significant impact on oral carcinogenesis (Mukherjee et al, 2011).…”

Section: Discussionsupporting

confidence: 74%

High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

Athirajan¹,

Razak²,

Thurairajah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: A comparative cross-sectional study involving oral cancer patients and healthy individuals was designed to investigate associations between retinol, α-tocopherol and β-carotene with the risk of oral cancer. Materials and Methods: This study included a total of 240 matched cases and controls where subjects were selected from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). Retinol, α-tocopherol and β-carotene levels and intake were examined by high-performance liquid chromatography (HPLC) and food frequency questionnaire (FFQ) respectively. Results: It was found that results from the two methods applied did not correlate, so that further analysis was done using the HPLC method utilising blood serum. Serum levels of retinol and α-tocopherol among cases (0.177±0.081, 1.649±1.670µg/ml) were significantly lower than in controls (0.264±0.137, 3.225±2.054µg/ml) (p<0.005). Although serum level of β-carotene among cases (0.106±0.159 µg/ml) were lower compared to controls (0.134±0.131µg/ml), statistical significance was not observed. Logistic regression analysis showed that high serum level of retinol (OR=0.501, 95% CI=0.254-0.992, p<0.05) and α-tocopherol (OR=0.184, 95% CI=0.091-0.370, p<0.05) was significantly related to lower risk of oral cancer, whereas no relationship was observed between β-carotene and oral cancer risk. Conclusions: High serum levels of retinol and α-tocopherol confer protection against oral cancer risk.

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Section: Discussionsupporting

confidence: 74%

High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

Athirajan¹,

Razak²,

Thurairajah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Two studies dealt with histological classification [115], [116]: no significant difference was observed in adenocarcinoma and squamous cell carcinoma using random effects and significant decrease in large cell carcinoma using fixed effects (−0.78; 95% CI, −1.32 to −0.23). serum zinc level and stage was analyzed in two studies [114], [116]. Klarod et al determined significantly lower serum zinc level in advanced compared to low stages [114].…”

Section: Resultsmentioning

confidence: 99%

“…serum zinc level and stage was analyzed in two studies [114], [116]. Klarod et al determined significantly lower serum zinc level in advanced compared to low stages [114]. Similarly, descending trend was observed between stages T1, T2, and T3 [116].…”

Section: Resultsmentioning

confidence: 99%

Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis

et al. 2014

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Background and ObjectivesCurrent studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper.MethodsWeb of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis.ResultsAnalysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size = −1.04), head and neck (effect size = −1.43), breast (effect size = −0.93), liver (effect size = −2.29), stomach (effect size = −1.59), and prostate (effect size = −1.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tissue (effect size = 1.80) and decrease in prostatic (effect size = −3.90), liver (effect size = −8.26), lung (effect size = −3.12), and thyroid cancer (effect size = −2.84). The rest of the included tumors brought ambiguous results, both in serum and tissue zinc levels across the studies. The association between zinc level and stage or grade of tumor has not been revealed by meta-regression.ConclusionThis study provides evidence on cancer-specific tissue zinc level alteration. Although serum zinc decrease was associated with most tumors mentioned herein, further – prospective - studies are needed.

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“…Numerous prospective studies show that serum levels of b-cryptoxanthin are inversely associated with the risk of a variety of cancers in several tissues (3,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). However, controversial results have been published, such as those describing no association between b-cryptoxanthin and risk of colon (20), breast (21), ovarian (22), and prostate cancer (23), and non-Hodgkin lymphoma (24).…”

Section: Introductionmentioning

confidence: 99%

β-Cryptoxanthin Synergistically Enhances the Antitumoral Activity of Oxaliplatin through ΔNP73 Negative Regulation in Colon Cancer

Millán

Soldevilla

Martín

et al. 2015

Clinical Cancer Research

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Background: The acquired resistance to chemotherapy represents the major limitation in the treatment of cancer. New strategies to solve this failure and improve patients' outcomes are necessary. The cancer preventive effect of b-cryptoxanthin has been widely described in population studies. Few reports support its putative use as an antitumoral compound. Here we focus on the therapeutic potential of b-cryptoxanthin individually or in combination with oxaliplatin in colon cancer and try to decipher the molecular basis underlying its effect.Methods: Apoptosis, viability and proliferation assays, mouse models, and an intervention study in 20 healthy subjects were performed. A PCR array was carried out to unravel the molecular putative basis of the b-cryptoxanthin effect, and further signaling experiments were conducted. Comet Assay was completed to evaluate the genotoxicity of the treatments.

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Serum antioxidant levels and nutritional status in early and advanced stage lung cancer patients

Cited by 25 publications

References 17 publications

High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis

β-Cryptoxanthin Synergistically Enhances the Antitumoral Activity of Oxaliplatin through ΔNP73 Negative Regulation in Colon Cancer

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