Serum Antimüllerian hormone does not predict elevated progesterone levels among women who undergo controlled ovarian hyperstimulation for in vitro fertilization

Kavoussi, Shahryar K.; Chen, Shu-Hung; Hunn, Caitlin; West, Brady T.; Wininger, J. David; Kavoussi, Keikhosrow M.; Kavoussi, Parviz K.

doi:10.1186/s12958-019-0477-8

Cited by 3 publications

(3 citation statements)

References 36 publications

(24 reference statements)

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“…However, AMH has not been shown to predict P4 rise on the day of oocyte aspiration. Our finding is consistent with a recent study by Kavoussi et al 25 , who also did not find a predictive value of AMH in P4 rise. Studies have shown that AMH can predict the response to ovarian stimulation as well as the number of achieved oocytes and embryos; however, its correlation with P4 rise has not been extensively studied 25 .…”

Section: Discussionsupporting

confidence: 93%

Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART

Tulić

Bila

et al. 2020

Sci Rep

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This study aimed to assess whether basal hormonal levels can predict the levels of progesterone (P4) on the day of oocyte retrieval (OR) and examine the impact of P4 levels on the day of OR on the outcome of assisted reproduction. One hundred sixty-four patients that were enrolled in the assisted reproduction procedure were classified according to their P4 levels on the OR day (< 2 ng/ml vs. ≥ 2 ng/ml). Patients who had P4 levels < 2 ng/ml had significantly higher follicle stimulating hormone (FSH) levels and significantly lower anti-Mullerian hormone (AMH) levels. More than half of patients with P4 levels < 2 ng/ml on the OR day got pregnant and delivered healthy infants. There was a significant correlation between lower FSH values and higher P4 values at OR and between higher AMH values and higher P4 values on the day of OR. Regression analysis showed that high FSH levels are the most important factor that can reliably imply lower P4 levels on OR day. Our study confirmed that lower basal FSH levels can predict the levels of P4 on the OR day. Moreover, lower levels of P4 on the day of OR are associated with a positive outcome in assisted reproduction.

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Section: Discussionsupporting

confidence: 93%

Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART

Tulić

Bila

et al. 2020

Sci Rep

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“…The endocrine and metabolic status of PCOS patients are relatively abnormal, which leads to important causes of abnormal uterine bleeding, infertility, and other adverse conditions, so the treatment needs of women in gestational age are often high [ 22 ]. This study aimed to investigate the relationship between the levels of endocrine and metabolic indicators and ultrasound parameters in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Ovarian Ultrasound Parameters and Endocrine and Metabolic Indicators in Patients with Ovarian Syndrome

Sheng

Zhang²,

Jiang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study is to investigate the relationship between the levels of endocrine and metabolic indicators and ovarian ultrasonography indicators in patients with ovarian syndrome (PCOS). Methods. Three hundred and forty patients with PCOS from January 2017 to February 2022 were selected as the observation group, and 340 healthy women of the same age were selected as the control group. A retrospective analysis was performed to observe the levels of endocrine and metabolic indicators and ovarian ultrasound examination indicators in the two groups. Results. The levels of testosterone, dehydroepiandrosterone (DHEA-S), luteinizing hormone (LH), LH/FSH, blood glucose, and insulin were higher in the observation group than those in the control group. The levels of low-density lipoprotein (LDL) and free insulin-like growth factor (IGF-I) were higher in the observation group than those in the control group. However, the level of high-density lipoprotein (HDL) was lower in the observation group than that in the control group. The ovarian interstitial area, total ovarian area, ovarian volume, number of follicles, uterine artery pulsatility index (PI), and resistance index (RI) were higher in the observation group than those in the control group. Pearson correlation analysis concluded that estrone (E1) levels in PCOS patients were correlated with ovarian interstitial area, total ovarian area, and ovarian volume. In addition, E1 levels correlated with LH levels, LH/FSH, testosterone, DHEA-S, and progesterone at P < 0.05 . Compared with different treatment methods, the total testosterone, LH, and LH/FSH levels in the two groups were decreased compared with those before treatment, and the degree of decrease in the combined treatment group was more significant than that in the treatment alone group. Conclusion. The levels of endocrine metabolism and ovarian ultrasound in PCOS patients are abnormal and there is a close relationship between the levels of endocrine metabolism and ovarian ultrasound. Attention should be paid to the monitoring and regulation of endocrine metabolism and ovarian ultrasound. Integrated traditional Chinese and western medicine can greatly improve the hormone levels in PCOS patients.

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“…The women from 30 to 44 years old are at high-risk of ovarian aging, and they are the main population receiving ART [5]. The clinical treatment of these patients generally adopts an "empirical" strategy, in which the choice of COH protocol is based on the patient's age, BMI, ovarian reserve, and clinical experience [23]. Before the implementation of ART, clinicians can predict the patient's ovarian response according to age-related ovarian reserve and provide patients with pre-treatment consultation.…”

Section: Discussionmentioning

confidence: 99%

Investigating the correlation between AMH and the number of high-quality embryos from IVF/ICSI in 30-44 year-old infertile women

chen

et al. 2022

Preprint

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Background To explore the effect of anti-Müllerian hormone (AMH) on embryonic development by studying the relationship between serum AMH concentration and the high-quality embryo number during the first cycle of in vitro fertilization (IVF) /intracytoplasmic sperm injection (ICSI) in 30-44 year-old infertile women.Methods A retrospective cohort study of 335 cycles was conducted. The study population was the patients who received the first IVF/ICSI cycle at the Reproductive Medicine Center of * * * * * * from January 2019 to December 2020. The basic characteristics, clinical medication and cycle outcome of patients were collected, and the correlation between AMH and the number of high-quality embryos was analyzed.Results After adjusted for confounding factors (female age, AFC and COH protocol), sensitivity analysis showed that high-quality embryo number in high AMH group increases by 2.2 units for each additional unit of AMH (≥8.5 ng/mL) (95%CI: (0.8, 3.7), P=0.003). The two-piecewise regression model identified the inflection point as AMH=7.1 ng/mL, and the effect size, 95% CI and P value on both sides of the inflection point were 0.5(0.3, 0.7), <0.001 and 0.1(-0.1, 0.2), 0.518, respectively. The results of stratified analysis and interaction test showed that the relationship between AMH and the high-quality embryo number was stable among different subgroups (P>0.05).Conclusion When AMH<7.1ng/mL, there is a positive correlation between AMH and the number of high-quality embryos in this study population. Therefore, the effect of age-related ovarian reserve biomarker AMH on reproductive prognosis can provide reference for ART clinical treatment.Plain English summary Diminished ovarian reserve (DOR) refers to a decrease in the number and/or quality of oocytes in the ovary, accompanied by a decrease in anti-Müllerian hormone (AMH) levels, a decrease in antral follicle count (AFC) and an increase in follicle stimulating hormone (FSH) levels. The most common clinical symptoms are shortened menstrual cycle and decreased menstrual flow. Most patients go to the hospital after long-term unsuccessful attempts to conceive, so delays in diagnosis are common. Assisted reproductive technology (ART) is the main means of achieving pregnancy in patients with DOR. With the improvement and adjustment of the ovulation induction program and the innovation of laboratory technology, the clinical pregnancy rate of ART has increased. However, DOR patients have poor ovarian response to gonadotropins (Gn), manifested as less follicle development, low blood estrogen levels, high Gn dosage, lower-than-expected oocyte retrieval, high cycle cancellation rate, and low clinical pregnancy rate in ovarian stimulation cycles. Therefore, this type of patients is a difficult point in the field of assisted reproduction. In the present study, elevated AMH was associated with an increased number of high-quality embryos in individuals aged 30-44 years at high risk for DOR. AMH can assess the potential reproductive prognosis of such patients and provide valuable data for clinical treatment of such patients.

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Serum Antimüllerian hormone does not predict elevated progesterone levels among women who undergo controlled ovarian hyperstimulation for in vitro fertilization

Cited by 3 publications

References 36 publications

Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART

Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART

The Relationship between Ovarian Ultrasound Parameters and Endocrine and Metabolic Indicators in Patients with Ovarian Syndrome

Investigating the correlation between AMH and the number of high-quality embryos from IVF/ICSI in 30-44 year-old infertile women

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