Serum antibody level to S-antigen in children with chronic uveitis.

Uusitalo, Risto; Stjernschantz, Johan; Mahlberg, Kaj; Gregerson, Dale S.; Uusitalo, Hannu; Tallberg, T; Palkama, Arto

doi:10.1136/bjo.69.3.212

Cited by 18 publications

(5 citation statements)

References 12 publications

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“…The occurrence of such antibodies in healthy subjects may be a natural phenomenon and is probably without harm. However, sharp increases in anti-S-antigen antibody titers have been reported to occur particularly in very active forms of uveoretinitis [31,32]. We found no evidence for enhanced humoral immune responsiveness to bovine S-antigen or opsin in the patient groups suffering from serpiginous choroiditis, APMPPE or retinitis pigmentosa.…”

Section: Discussioncontrasting

confidence: 42%

Immune responsiveness to retinal S-antigen and opsin in serpiginous choroiditis and other retinal diseases

et al. 1988

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The immune responsiveness to bovine retinal S-antigen and opsin has been investigated in some retinal disorders by means of in vitro lymphocyte proliferation, leukocyte migration inhibition and enzyme linked immune sorbent assays (ELISA). Sensitisation to S-antigen was observed in serpiginous choroiditis, but not in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) or retinitis pigmentosa. No significant immune responsiveness was detected to opsin in any of the three diseases. Elevated antibody titers to S-antigen were observed in some individual patients and healthy subjects. However, none of the patient groups exhibited an elevated antibody titer as compared to the control group. Although serpiginous choroiditis and APMPPE share some prominent clinical characteristics, the sensitisation in the former disease may perhaps be attributed to more severe and prolonged damage of the photoreceptor cells and blood-retina barrier. A combination of previous and present results suggests that in immunological investigations of retinitis pigmentosa patients it is more effective to use human than bovine S-antigen as test antigen because a species specific epitope seems to be involved.

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Section: Discussioncontrasting

confidence: 42%

Immune responsiveness to retinal S-antigen and opsin in serpiginous choroiditis and other retinal diseases

et al. 1988

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“…In a recent study, antibody to antigen S was demonstrated in some children with uveitis complicating JRA (23). The uveitogenic potential of antigen S in animal systems and its accompaniment by cellular or humoral immunity to the antigen support the possibility that such immunoreactivity in children with JRA and uveitis may be pathogenically important.…”

Section: Discussionmentioning

confidence: 96%

Immunity to soluble retinal antigen in patients with uveitis accompanying juvenile rheumatoid arthritis

Petty

Hunt

Rollins

et al. 1987

Arthritis & Rheumatism

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Studies of immunity to bovine soluble retinal antigen (antigen S) were carried out using serum and peripheral blood lymphocytes from children with juvenile rheumatoid arthritis and chronic anterior uveitis (JRA‐uveitis), children with JRA alone, children with nonrheumatic diseases, and controls who had no ocular or rheumatic disease. Enzyme‐linked immunosorbent assay and the lymphocyte transformation assay were used to determine immunity. Antibody to antigen S was present significantly more frequently in children with JRA‐uveitis than in children with JRA alone, children with nonrheumatic disorders, or controls. These latter groups did not differ in positivity for this antibody. Lymphocyte transformation occurred more frequently in children with JRA–uveitis than in children with JRA alone or controls. Children with JRA alone and controls had similar frequencies of lymphocyte transformation positivity. Enzyme‐linked immunosorbent assay positivity and lymphocyte transformation positivity tended to occur in different children. Children with JRA–uveitis who had HLA–B35 had the highest frequency of antibody to antigen S. Immunity to antigen S may be the result of ocular damage by mechanisms other than a pathogenic mechanism per se.

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“…Animal models of experimental uveitis have employed a variety of agents, including soluble retinal antigen (S antigen) [2] and lens crystallins [3]. Studies in this laboratory [4] and others [5] have demonstrated humoral and cellmediated immunity to bovine S antigen in some children with JRA and uveitis. Studies of immunoreactivity to lens crystallins in children with JRA have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Immunity to Ocular and Collagen Antigens in Childhood Arthritis and Uveitis

Petty

Hunt²

1989

Int Arch Allergy Immunol

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Humoral and cellular immunity to ocular antigens (S antigen and alpha, beta heavy, beta light, and gamma crystallins) and connective tissue antigens (type I, II, III, and IV collagens) were studied in children with juvenile rheumatoid arthritis (JRA) with or without uveitis and in controls. There was no association between the presence of uveitis and antibody to any collagen type or of lymphocyte transformation to type II collagen. Antibodies to all crystallins were more common in children with JRA than in controls, and antibodies to BH crystallins were more frequent in children with JRA and uveitis than in those with JRA alone. Such reactivity did not appear to represent antibody cross-reactive with collagen antigens. Lymphocyte proliferation to alpha crystallin was increased in JRA with or without uveitis, whereas lymphocyte response to S antigen was associated with the presence of uveitis.

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Serum antibody level to S-antigen in children with chronic uveitis.

Cited by 18 publications

References 12 publications

Immune responsiveness to retinal S-antigen and opsin in serpiginous choroiditis and other retinal diseases

Immune responsiveness to retinal S-antigen and opsin in serpiginous choroiditis and other retinal diseases

Immunity to soluble retinal antigen in patients with uveitis accompanying juvenile rheumatoid arthritis

Immunity to Ocular and Collagen Antigens in Childhood Arthritis and Uveitis

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