Serum antibody for somatostatin-14 and prodynorphin 209–240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection

Roy, Benjamin F.; Benkelfat, Chawki; Hill, James L.; Pierce, Phillip F.; Dauphin, M.; Kelly, Theresa M.; Sunderland, Trey; Weinberger, Daniel R.; Breslin, Nancy A.

doi:10.1016/0006-3223(94)90037-x

Cited by 34 publications

(13 citation statements)

References 58 publications

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“…In support of this idea, high levels of serum immunoglobulins, specially IgG, and increased cerebrospinal fluid levels of IgG antibodies for herpes simplex virus type 1 have been found in subjects with OCD [6,7]. Moreover, serum antibodies for somatostatin-14 and prodynorphin 209-240 have been detected in such patients [8].…”

Section: Introductionmentioning

confidence: 66%

Decreased Blood Levels of Tumor Necrosis Factor-Alpha in Patients with Obsessive-Compulsive Disorder

Monteleone¹,

Catapano²,

Fabrazzo³

et al. 1998

Neuropsychobiology

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To investigate immune system function in obsessive-compulsive disorder (OCD) we measured plasma levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in 14 drug-free obsessive-compulsive patients and 14 matched healthy controls. No significant differences were observed between patients and controls in plasma levels of IL-1β and IL-6, whereas plasma levels of TNF-α were significantly lower (p = 0.001) in the former. Blood levels of prolactin did not differ between the two groups, whereas plasma cortisol concentrations were significantly higher in patients than in healthy subjects (p = 0.02). No significant correlation was found between immune parameters, on the one hand, and endocrine or psychopathological measures on the other. These results suggest that OCD is associated with a decreased production in TNF-α, but normal synthesis of IL-1β and IL-6.

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Section: Introductionmentioning

confidence: 66%

Decreased Blood Levels of Tumor Necrosis Factor-Alpha in Patients with Obsessive-Compulsive Disorder

Monteleone¹,

Catapano²,

Fabrazzo³

et al. 1998

Neuropsychobiology

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“…Furthermore, in another study patients with OCD demonstrated significant levels of antibody for prodynorphin in blood, while healthy subjects and disease control groups, namely schizophrenia, Alzheimer's disease, multiple sclerosis, and subjects with advanced human immunodeficiency virus infection, showed negligible reactivity (Roy et al, 1994).…”

Section: Anxiety and Illicit Opioid Usementioning

confidence: 96%

Opioids and anxiety

et al. 2010

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The opioid system plays a crucial role in the neural modulation of anxiety. The involvement of opioid ligands and receptors in physiological and dysfunctional forms of anxiety is supported by findings from a wide range of preclinical and clinical studies, including clinical trials, experimental research, and neuroimaging, genetic, and epidemiological data. In this review we provide a summary of studies from a variety of research disciplines to elucidate the role of the opioid system in the neurobiology of anxiety. First, we report data from preclinical studies using animal models to examine the modulatory role of central opioid system on defensive responses conducive to fear and anxiety. Second, we summarize the human literature providing evidence that clinical and experimental human studies are consistent with preclinical models. The implication of these data is that activation of the opioid system leads to anxiolytic responses both in healthy subjects and in patients suffering from anxiety disorders. The role of opioids in suppressing anxiety may serve as an adaptive mechanism, collocated in the general framework of opioid neurotransmission blunting acute negative and distressing affective responses.

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“…(3) There are studies reporting different opioid peptide levels in the biological fluids of OCD as compared with healthy volunteers. For example, there were studies showing that OCD patients have elevated serum antibodies for the dynorphin precursor prodynorphin, when compared with healthy controls [7]. However, in children and adolescents with OCD, CSF dynorphin levels failed to correlate with the severity of OC symptoms [8].…”

Section: Introductionmentioning

confidence: 99%

Do Obsessive-Compulsive Patients and Abstinent Heroin Addicts Share a Common Psychophysiological Mechanism?

et al. 2003

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Background/Aim: Working memory (WM) and attentional deficits have been implicated in the pathophysiology of both obsessive-compulsive disorder (OCD) and opioid addiction. The P300 component of event-related potentials (ERPs) is considered as an index of on-line updating of WM and/or attentional operations involved in this function. The present study aimed at comparing the P300 elicited during a WM test in patients with prolonged heroin abstinence, those with OCD and healthy controls, in order to demonstrate possibly common underlying psychophysiological mechanisms. Methods: The P300 component was evaluated during the anticipatory period of a WM test in 20 patients characterized by a past history of opioid dependence (6 months abstinence), in 18 OCD patients, and 20 healthy subjects matched for age, sex and educational level. Results: The two patient groups showed a considerable reduction of the P300 amplitudes, located at the right frontal area as compared with healthy controls. The abstinent heroin addicts exhibited a significantly lower P300 amplitude at central frontal areas and a significantly higher P300 amplitude at the left occipital region relative to the other two groups. Furthermore, the abstinent group showed a notable delay of P300 latency relative to controls and OCD patients at the right occipital region. Moreover, the OCD patients manifested a significant prolongation of P300 located at the central prefrontal area, relative to addicts and healthy controls. Conclusions: These findings point to considerable WM and/or attentional deficits in the long-term abstinent syndrome of heroin misuse and OCD associated with distributed and prefrontal cortical circuits, respectively. Furthermore, the present findings suggest that both OCD and long-term abstinent heroin addicts may share a common impairment of WM and/or attention involving or affecting the right prefrontal areas.

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Serum antibody for somatostatin-14 and prodynorphin 209–240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection

Cited by 34 publications

References 58 publications

Decreased Blood Levels of Tumor Necrosis Factor-Alpha in Patients with Obsessive-Compulsive Disorder

Decreased Blood Levels of Tumor Necrosis Factor-Alpha in Patients with Obsessive-Compulsive Disorder

Opioids and anxiety

Do Obsessive-Compulsive Patients and Abstinent Heroin Addicts Share a Common Psychophysiological Mechanism?

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