Serum antibodies against respiratory tract viruses: A prospective three-year follow-up from birth

Harsten, Göran; Prellner, Karin; Löfgren, Bengt; Heldrup, Jesper; Kalm, Olof; Kornfält, Ragnhild

doi:10.1017/s0022215100110473

Cited by 14 publications

(10 citation statements)

References 14 publications

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“…first 2 years of life, of which 13 were associated with mild URTI and seven were found during routine sampling of clinically healthy infants. The prevalence of RSVspecific serum IgG antibodies in infants' samples at the age of 18 or 24 months indicated that the majority had experienced at least one RSV infection in the first 2 years of life, in accordance with other cohort studies [Harsten et al, 1989;Moylett and Piedra, 1999]. Based on the literature, it was expected that few primary RSV infections would be asymptomatic [Collins et al, 1996], most infections would be associated with URTI, and 25-40% with RSV bronchiolitis [Martin et al, 1978;Hall et al, 1979;Weigl et al, 2001].…”

Section: Discussionsupporting

confidence: 89%

Moderate local and systemic respiratory syncytial virus‐specific T‐cell responses upon mild or subclinical RSV infection

Waal

Koopman

Benten

et al. 2003

Journal of Medical Virology

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Respiratory syncytial virus (RSV) infections are a major cause of severe respiratory disease in infants. It has been shown that there is an increased frequency of childhood wheezing in ex-bronchiolitic preteen children. This was postulated to be mediated by a vigorous virus-specific Th2 response influencing the further development of the immune system. Little is known about the possible role of the immune response to clinically mild RSV infections in this respect. We have studied the RSV-specific cellular immune response in infants with a laboratory-confirmed RSV upper respiratory tract infection (URTI; n = 13, mean age 12 months, range 2-22 months) in comparison with infants with non-RSV mediated URTI (n = 9, mean age 9.3 months, range 4-18 months) or infants with severe RSV bronchiolitis (n = 11, mean age 2.3 months, range 1-6 months). RSV-specific cytokine-producing cells were enumerated using the ELISPOT method in peripheral blood mononuclear cells and nasal brush T-cells, collected during the acute and convalescent phase of the infection. Mixed Th1 (IFN-gamma) and Th2 (IL-4 and IL-13) responses were detected in all three groups. Frequencies of RSV-specific T-cells were lower in both URTI groups than in the RSV bronchiolitis group, and not significantly different between the RSV URTI and the non-RSV URTI group. The absence of vigorous virus-specific Th2 responses upon mild RSV infection does not support the hypothesis that these infections influence the development of the immune system and that they predispose for the development of atopic disease.

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Section: Discussionsupporting

confidence: 89%

Moderate local and systemic respiratory syncytial virus‐specific T‐cell responses upon mild or subclinical RSV infection

Waal

Koopman

Benten

et al. 2003

Journal of Medical Virology

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“…Our result, that approximately 85% of all children were seropositive for RSV by 3 y of age, is in line with earlier studies [11,12]. Due to our study design, we may have missed early RSV infections (not inducing IgG antibodies in significant amounts) since one-third of children were recruited into the study during their second year of life [7].…”

Section: Discussionsupporting

confidence: 89%

“…It is known that the presence of maternal antibodies affects infants' ability to develop an immune response to RSV [10], and a substantial proportion of hospitalized infants experiencing their first RSV infection do not show a rise in antibody titres [11]. In those infected, antibody titres are age dependent, showing marked increase after 6 to 9 mo of age [11,12]. Thus, lack of antibodies is not always an indication of no previous exposure [11].…”

Section: Discussionmentioning

confidence: 99%

Respiratory syncytial virus infection in children hospitalized for wheezing: Virus-specific studies from infancy to preschool years

Kotaniemi‐Syrjänen¹,

Laatikainen²,

Waris³

et al. 2005

Acta Paediatrica

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Hospitalization for wheezing in infancy is associated with increased risk for later childhood asthma, particularly in children without RSV infection on admission, although children with RSV have also slightly increased risk for later asthma. However, mere serological evidence of RSV infection is not associated with the development of asthma. In addition to RSV, more attention should be paid to less virulent agents in order to find those wheezing infants who are at particular risk of later childhood asthma.

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“…This is likely to decrease during later childhood because prevalences up to 13% have been reported in adults (30). At the age of 18 months, most children (75%) will have been infected with RSV at least once (31). The prevalence of rhinovirus increases slowly to more than 50%.…”

Section: Discussionmentioning

confidence: 99%

Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants

Benten¹,

Koopman²,

Niesters

et al. 2003

Pediatric Allergy Immunology

125

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Respiratory infections in infancy may protect against developing Th2-mediated allergic disease (hygiene hypothesis). To estimate the relative contribution of particular viruses to the development of the immune system and allergic disease, we investigated longitudinally the prevalence of respiratory viral infections in infants. One hundred and twenty-six healthy infants were included in this prospective birth cohort study in their first year of life. Physical examination was performed and nasal brush samples were taken during routine visits every 6 months and during an upper respiratory tract infection (URTI) (sick visits). The prevalence of respiratory viral infections in infants with URTI, infants with rhinitis without general malaise and infants without nasal symptoms was studied. Rhinovirus was the most prevalent pathogen during URTI and rhinitis in 0- to 2-year-old infants ( approximately 40%). During URTI, also respiratory syncytial virus ( approximately 20%) and coronavirus ( approximately 10%) infections were found, which were rarely detected in infants with rhinitis. Surprisingly, in 20% of infants who did not present with nasal symptoms, rhinovirus infections were also detected. During routine visits at 12 months, a higher prevalence of rhinovirus infections was found in infants who attended day-care compared with those who did not. We did not observe a relation between breast-feeding or smoking by one or both parents and the prevalence of rhinovirus infections. The parental history of atopy was not related to the prevalence of rhinovirus infection, indicating that the genetic risk of allergic disease does not seem to increase the chance of rhinovirus infections. In conclusion, rhinovirus infection is the most prevalent respiratory viral infection in infants. It may therefore affect the maturation of the immune system and the development of allergic disease considerably.

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Serum antibodies against respiratory tract viruses: A prospective three-year follow-up from birth

Cited by 14 publications

References 14 publications

Moderate local and systemic respiratory syncytial virus‐specific T‐cell responses upon mild or subclinical RSV infection

Moderate local and systemic respiratory syncytial virus‐specific T‐cell responses upon mild or subclinical RSV infection

Respiratory syncytial virus infection in children hospitalized for wheezing: Virus-specific studies from infancy to preschool years

Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants

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