Abstract:Periodontitis is associated with an increased risk of atherosclerosis, and accumulating evidence suggests a positive association between anti-heat shock protein 60 autoantibodies and atherosclerosis in humans. Heat shock proteins of the GroEL or HSP60 class are highly conserved proteins essential to all living organisms. In this study, we examined the effects of immunization with recombinant HSP60 from Porphyromonas gingivalis on antibody responses and the development of atherosclerosis.Atherosclerosis was exa… Show more
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