Serum anti‐Müllerian hormone is associated with oocyte dysmorphisms and <scp>ICSI</scp> outcomes

Azizi, Elham; Naji, Mohammad; Nazari, Leila; Salehpour, Saghar; Karimi, Maryam; Borumandnia, Nasrin; Mofarahe, Zahra Shams

doi:10.1002/ijgo.12941

Cited by 5 publications

(10 citation statements)

References 24 publications

(40 reference statements)

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“…Compared with women with elevated levels of FSH but lower levels of AMH, women with variable serum AMH levels that are greater than or equal to 0.6 ng/ml had more oocytes retrieved, more embryos on day 3, and a lower transfer cancellation rate ( 33 ). Another study concluded that serum levels of AMH were associated with specific oocyte dysmorphisms and an average oocyte quality index ( 34 ). The rates of fertilization and high-quality embryos are crucial aspects affecting blastocyst formation.…”

Section: Discussionmentioning

confidence: 99%

The Development of Nomograms to Predict Blastulation Rate Following Cycles of In Vitro Fertilization in Patients With Tubal Factor Infertility, Polycystic Ovary Syndrome, or Endometriosis

et al. 2021

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It is well known that the transfer of embryos at the blastocyst stage is superior to the transfer of embryos at the cleavage stage in many respects. However, the rate of blastocyst formation remains low in clinical practice. To reduce the possibility of wasting embryos and to accurately predict the possibility of blastocyst formation, we constructed a nomogram based on range of clinical characteristics to predict blastocyst formation rates in patients with different types of infertility. We divided patients into three groups based on female etiology: a tubal factor group, a polycystic ovary syndrome group, and an endometriosis group. Multiple logistic regression was used to analyze the relationship between patient characteristics and blastocyst formation. Each group of patients was divided into a training set and a validation set. The training set was used to construct the nomogram, while the validation set was used to test the performance of the model by using discrimination and calibration. The area under the curve (AUC) for the three groups indicated that the models performed fairly and that calibration was acceptable in each model.

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Section: Discussionmentioning

confidence: 99%

The Development of Nomograms to Predict Blastulation Rate Following Cycles of In Vitro Fertilization in Patients With Tubal Factor Infertility, Polycystic Ovary Syndrome, or Endometriosis

et al. 2021

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“…In the recent years AMH has been shown to represent a reliable marker of ovarian reserve and ovarian stimulation response (Fridén et al, 2011;Brugo Olmedo et al, 2013). Although knowledge of the physiologic role of AMH remains limited, various studies have demonstrated its importance as regulator of ovarian activity (Azizi et al, 2019). AMH, a member of the transforming growth factor-β family, has the primary role of regression of the Müllerian duct in the male fetus during early testis differentiation, persisting after completion of the male reproductive system, and commencing in females in early fetal life, produced by ovarian granulosa cells (Nelson et al, 2007;Brugo Olmedo et al, 2013) of pre-antral and small antral follicles (Nelson et al, 2007;Lee et al, 2009;Fridén et al, 2011;Brugo Olmedo et al, 2013;La Marca et al, 2017).…”

Section: Ovarian Reservementioning

confidence: 99%

“…Additionally, as granulosa cells exert important roles in folliculogenesis, AMH could also influence the quality of oocytes (Azizi et al, 2019).…”

Section: Ovarian Reservementioning

confidence: 99%

“…High AMH levels were also associated with lower cycle cancellation rates (Fridén et al, 2011;Lee et al, 2011;Brodin et al, 2013;Brugo Olmedo et al, 2013;Lin et al, 2014), good response rate (≥ 5 retrieved oocytes) (Brugo Olmedo et al, 2013), higher mean number of retrieved oocytes (Lee et al, 2009;Fridén et al, 2011;Brugo Olmedo et al, 2013;Li et al, 2016;Daney de Marcillac et al, 2017;Azizi et al, 2019) and metaphase II oocytes (Azizi et al, 2019), and higher CPR (Azizi et al, 2019;Fridén et al, 2011;Lee et al, 2011;Brodin et al, 2013;Brugo Olmedo et al, 2013).…”

Section: Ovarian Reservementioning

confidence: 99%

“…It is not only important to predict those who can expect low outcomes, warning poor responders and modifying stimulation approaches, but also to identify high responding patients at risk for ovarian hyperstimulation syndrome (Nelson et al, 2007;Lee et al, 2009;Brodin et al, 2013;Brugo Olmedo et al, 2013;Li et al, 2016;Liao et al, 2016;Reijnders et al, 2016). On one hand, studies have shown that markers of ovarian reserve are useful in the individualization of stimulation, but on the other, further association with clinical pregnancy rate (CPR) and live birth rate (LBR) have varied and been disputed (Lee et al, 2009;Brodin et al, 2013;Amsiejiene et al, 2017;Azizi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes

Ribeiro¹,

Sousa²

2022

JBRA

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The development of assisted reproductive technology has allowed offspring in infertile couples, and specifically, allowed infertile men to conceive through Intracytoplasmic Sperm Injection (ICSI). Despite the proven efficacy of In Vitro Fertilisation (IVF) and ICSI, many factors can influence its success. In this review we present an analysis on the effect of Female age, Ovarian Reserve, Male age and Male factor on the outcomes of IVF/ICSI, to determine if and which can be applied to the practical context. A literature search on PubMed, EMBASE and MEDLINE for relevant articles was elaborated until July 2021, leading to the selection of 234 articles based on their titles. After reading through the abstracts, those that evaluated IVF/ ICSI predicting factors were selected. Finally, only those approaching female age, ovarian reserve, male age and male factor were considered in this review. Higher female age and baseline ovarian markers alterations such as lower anti-Müllerian hormone and antral follicular count, and higher basal follicle-stimulating hormone, were associated with poorer outcomes. The predictive value of Male age and Male factor presented varied results across literature. The multifactorial nature of male fertility makes evaluation difficult. Although the first assessment of male infertility is based on sperm concentration, motility and morphology, semen parameters have shown low prognostic value, whilst sperm DNA alterations gain importance. Nevertheless, results remain controversial. While some factors have proven to predict IVF/ICSI success, other need to be further studied to be applied to practical context to allow the best prognosis possible.

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The ultrastructural nature of human oocytes’ cytoplasmatic abnormalities and the role of cytoskeleton dysfunction

Tatíčková

Trebichalská

Kyjovská³

et al. 2023

Preprint

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Egg quality is a limiting factor of female fertility and assisted reproductive technology (ART) success. Oocytes recovered from hyperstimulated ovaries often display morphological anomalies suspected to compromise their fertilization and developmental potential. Knowledge of (ab)normal oocyte’s intracellular organization is vital to establish reliable criteria for morphological evaluation of oocytes intended for in vitro fertilization (IVF). Here, we investigated the fine morphology of 22 dysmorphic IVF oocytes exhibiting different types of cytoplasmic irregularities, namely (1) refractile bodies, (2) centrally-located cytoplasmic granularity (CLCG), (3) smooth endoplasmic reticulum (SER) disc, and (4) vacuoles. Transmission electron microscopy (TEM) revealed the structural basis of these aberrations and indicated that the underlying cause of two of the studied morphotypes was inordinate organelle clustering. To address the mechanism required for accurate organelle positioning, we used cytoskeleton-targeting chemical compounds and performed a series of inhibition experiments involving a total of 133 human oocytes maturing in vitro. Fluorescence and electron microscopy showed that disruption of actin, not microtubules, led to the aggregation of subcellular structures resembling the morphological pattern seen in abnormal oocytes. These results imply that actin serves as a regulator of organelle distribution during human oocyte maturation. The ultrastructural analogy between dysmorphic eggs retrieved in IVF cycles and oocytes, in which actin network integrity was perturbed, suggests that dysfunction of the actin cytoskeleton might be implicated in generating common cytoplasmic aberrations. Knowledge of human oocytes’ inner workings and the origin of morphological abnormalities is a step forward to more objective egg quality assessment in clinical practice.SUMMARY SENTENCEUltrastructural analysis of eggs exhibiting cytoplasmic abnormalities combined with inhibition experiments indicates that dysfunction of the actin network might be involved in the development of oocyte dysmorphisms.

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Serum anti‐Müllerian hormone is associated with oocyte dysmorphisms and ICSI outcomes

Cited by 5 publications

References 24 publications

The Development of Nomograms to Predict Blastulation Rate Following Cycles of In Vitro Fertilization in Patients With Tubal Factor Infertility, Polycystic Ovary Syndrome, or Endometriosis

The Development of Nomograms to Predict Blastulation Rate Following Cycles of In Vitro Fertilization in Patients With Tubal Factor Infertility, Polycystic Ovary Syndrome, or Endometriosis

In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes

The ultrastructural nature of human oocytes’ cytoplasmatic abnormalities and the role of cytoskeleton dysfunction

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