Serum anti-Müllerian hormone concentration before and after salpingectomy for ectopic pregnancy

Grynnerup, Anna G.-A.; Lindhard, Anette; Sørensen, Steen; Ørskov, Mette; Petersen, Kathrine Birch; Madsen, Lisbeth Buss; Pilsgaard, Fie; Løssl, Kristine; Pinborg, Anja

doi:10.1016/j.rbmo.2018.08.013

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…Details of the five studies that were not included in the meta‐analyses are presented in Table 2. The AMH and AFC values contained in these studies were presented as either a median and interquartile range or decreasing amount 31,32,37,45 …”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the 21 studies, including the 5 studies excluded from the meta-analysis are shown in Table 1. These studies included six prospective cohorts, [29][30][31][32][33][34] three cross-sectional studies, [35][36][37] eight retrospective studies, 25,26,[38][39][40][41][42][43] and four RCTs. 24,[44][45][46] There were 15 studies that specified whether unilateral or bilateral salpingectomy was performed.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The AMH and AFC values contained in these studies were presented as either a median and interquartile range or decreasing amount. 31,32,37,45 Comparison of AMH levels before and after surgery AMH levels before and after surgery were reported in eight studies. In the meta-analysis, including all studies that did not specify whether unilateral or bilateral salpingectomy was performed, there was no significant difference in the AMH levels before and after surgery (mean difference: À0.24; 95%CI [À0.89, 0.40], Figure 2a).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Effect of salpingectomy on ovarian reserve: A systematic review and meta‐analysis

Kobayashi

Kitahara

Hasegawa

et al. 2022

J of Obstet and Gynaecol

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Aim To determine the effect of salpingectomy on ovarian reserve. Methods PubMed, EMBASE, Web of Science, Dynamed plus, and Cochrane Controlled Trials Register databases were searched from their inception to December 2020 to identify relevant studies, including cross‐sectional studies, retrospective studies, and randomized controlled trials. Studies that compared anti‐Müllerian hormone (AMH) levels and/or antral follicle count (AFC) between the control and salpingectomy groups or before and after surgery were included. Results Twenty‐one articles were included in the systematic review. Meta‐analyses were performed on 16 studies in which data were presented as mean ± SD values. A meta‐analysis comparing AMH levels before and after surgery in the same patients showed no significant decrease in all cases, irrespective of whether it was unilateral or bilateral salpingectomy. There was no significant decrease in the AFC in the meta‐analysis comparing levels before and after bilateral salpingectomy, either. In contrast, in the case–controlled study the salpingectomy group had significantly lower levels of AMH in all meta‐analyses of unilateral and bilateral surgery (mean difference: −0.31, 95% confidence interval [CI]: −0.55, −0.07), only unilateral cases (mean difference: −0.28, 95% CI: −0.50, −0.06), and only bilateral cases (mean difference: −0.71, 95% CI: −1.19, −0.23). The salpingectomy group that included unilateral and bilateral cases had significantly lower AFC compared with no‐surgery controls (mean difference: −1.31, 95% CI: −2.13, −0.48). Conclusion Although not conclusive, it does appear that patients who underwent salpingectomy (either unilateral or bilateral) have a decreased ovarian reserve.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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Effect of salpingectomy on ovarian reserve: A systematic review and meta‐analysis

Kobayashi

Kitahara

Hasegawa

et al. 2022

J of Obstet and Gynaecol

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“…Furthermore, it is possible that salpingectomy does not alter ovarian reserve, but only the ovarian response, meaning the capacity to respond to FSH, either endogenous or exogenous, such as in ART. This could explain the absence of significant differences in the ovarian reserve, reflected by the AFC count [18,21,32,38,40,41] or AMH levels [18,21,32,38,42], as the surgery does not affect the ovarian cortex and the number of follicles present since embryonic stage remains constant. However, these follicles may not receive as optimal stimulation as before.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Follicular Response Is Altered by Salpingectomy in Assisted Reproductive Technology: A Pre- and Postoperative Case–Control Study

Reitz,

Balaya,

Pache

et al. 2023

JCM

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Objectives: The goal of this study was to assess the effect of unilateral salpingectomy on the number of mature follicles in the ipsilateral ovary during an assisted reproductive technology (ART) stimulation cycle, as compared to the contralateral ovary. Methods: This was a retrospective, single-center, case–control cohort study conducted from 2017 to 2022. Patients from 18 to 43 years old who underwent at least one ART cycle before and after a unilateral salpingectomy were included. The number of recruited follicles, including mature (≥16 mm) and intermediate follicles (13–15.5 mm), on the salpingectomy side (case) were compared to those present on the contralateral ovary (control) during an ART attempt. To take into account the inter-ovarian variability, the comparison was performed on two ART cycles, performed before then after the salpingectomy. Results: Overall, 24 patients were included in our study. While the number of mature follicles was similar in both ovaries before surgery, the mean number of mature follicles was significantly reduced after salpingectomy in the operated side, as compared to the control side, being, respectively 3.00 vs. 5.08 (p = 0.048). There was no significant difference between the intermediate and total recruited follicles. Conclusions: Our study suggests that salpingectomy may impact the follicle recruitment on the ipsilateral side by altering the vascularization during mesosalpinx coagulation. Gynecologists should be mindful of this concept and accurately set surgical indications. Beyond the indication, this emphasizes the critical role of having infertility surgeons sensitive to fertility preservation for optimal management of ART patients. Further studies with larger patient populations are required to confirm these results.

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The role of surgery in infertility, an evidence-based approach

Ata,

Turkgeldi,

Bozdag

2024

Handbook of Current and Novel Protocols for the Treatment of Infertility

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Serum anti-Müllerian hormone concentration before and after salpingectomy for ectopic pregnancy

Cited by 4 publications

References 29 publications

Effect of salpingectomy on ovarian reserve: A systematic review and meta‐analysis

Effect of salpingectomy on ovarian reserve: A systematic review and meta‐analysis

Ovarian Follicular Response Is Altered by Salpingectomy in Assisted Reproductive Technology: A Pre- and Postoperative Case–Control Study

The role of surgery in infertility, an evidence-based approach

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