Serum Anti-&lt;i&gt;Helicobacter pylori&lt;/i&gt; IgG Antibody Titer in &lt;i&gt;H. pylori&lt;/i&gt;-negative Cases with a Different Gastric Mucosal Atrophy Status

Adachi, Kyoichi; Kishi, Kanako; Notsu, Takumi; Mishiro, Tsuyoshi; Sota, Kazunari; Ishimura, Norihisa; Ishihara, Shunji

doi:10.2169/internalmedicine.5132-20

Cited by 6 publications

(7 citation statements)

References 17 publications

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“…Serum anti‐ H. pylori IgG antibody detection was performed with a SphereLight H. pylori antibody J kit, and the antibody titer was automatically determined using a chemiluminescent enzyme immunoassay method, with a value ≥ 4.0 U/ml defined as positive, according to the manufacturer's instructions. 7 , 8 , 9 In addition, a precise medical history concerning the status of H. pylori infection (negative, positive, post‐eradication) was obtained in an interview with the subject conducted by a public health nurse. Usage of a proton pump inhibitor or H2 receptor antagonist (H2RA) within the preceding 3 months was also determined at the time of the interview, although details related to duration or dosage of anti‐secretory drugs were not obtained for this study.…”

Section: Methodsmentioning

confidence: 99%

“…Those with a history of gastric surgery or whose status of H. pylori infection could not be determined based on medical records and/or serum antibody test findings were excluded from enrollment. Serum anti‐ H. pylori IgG antibody detection was performed with a SphereLight H. pylori antibody J kit, and the antibody titer was automatically determined using a chemiluminescent enzyme immunoassay method, with a value ≥ 4.0 U/ml defined as positive, according to the manufacturer's instructions 7–9 . In addition, a precise medical history concerning the status of H. pylori infection (negative, positive, post‐eradication) was obtained in an interview with the subject conducted by a public health nurse.…”

Section: Methodsmentioning

confidence: 99%

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Endoscopic findings of cardiac lymphoid hyperplasia and Helicobacter pylori infection status

et al. 2021

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Objective Lymphoid hyperplasia is endoscopically observed as multiple small whitish round nodules or spots. This retrospective study was performed to examine the prevalence of that finding in patients with Barrett's epithelium and its relationship with the status of H. pylori infection. Methods The study subjects were 3353 patients (males 2186, females 1167; mean age 55.2 ± 9.4 years) in whom the status of H. pylori infection had been determined. The presence of Barrett's epithelium ≥ 5 mm in length was endoscopically determined, and then endoscopic observations with blue laser imaging were used to investigate the presence of lymphoid hyperplasia in those areas. Results Barrett's epithelium was diagnosed in 1884 (56.2%) of the subjects, and endoscopic findings of lymphoid hyperplasia were observed in 402 (21.3%) of those with Barrett's epithelium. Lymphoid hyperplasia in Barrett's epithelium was not present in any without a current or prior H. pylori infection, while the prevalence of lymphoid hyperplasia in H. pylori ‐positive and post‐eradicated subjects was 48.4% and 30.4%, respectively ( p < 0.001). Multiple logistic regression analysis revealed that female gender, younger age, and higher degree of gastric mucosal atrophy were significant factors related to lymphoid hyperplasia positivity. In addition, the duration after H. pylori eradication was negatively correlated with its prevalence. Conclusion Endoscopic findings of cardiac lymphoid hyperplasia were well correlated with H. pylori infection, although prevalence decreased over time following bacterial eradication.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Endoscopic findings of cardiac lymphoid hyperplasia and Helicobacter pylori infection status

et al. 2021

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“…AG and IM are considered pre-neoplastic gastric lesions, but studies have observed that H. pylori infection status can spontaneously become negative in advanced AG [37, 38]. Plausible explanations include the unintentional eradication when treating another infection, the spontaneous disappearance of H. pylori due to severe mucosal atrophy and IM [39, 40], and the effects of the accompanying microbiota in H. pylori -infected individuals [41].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection as a Predictor of Treatment Outcomes of Gastric Cancer: A Systematic Review and Meta-Analysis

Gan

Shen

et al. 2023

Dig Dis

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Background: Helicobacter pylori infection is strongly associated with gastric cancer. However, there is currently no consensus on the association between H. pylori and gastric cancer prognosis. Methods: A systematic search was conducted on studies in PubMed, EMBASE, and Web of Science up to March 10, 2022. The quality of all included studies was assessed using the Newcastle-Ottawa Scale. The hazard ratio (HR) and its 95% confidence interval (95%CI) were extracted to analyze the association between H. pylori infection and prognosis of gastric cancer. In addition, subgroup analysis and publication bias were performed. Results: A total of 21 studies were involved. The pooled HR was 0.67 (95%CI, 0.56-0.79) for overall survival (OS) in H. pylori-positive patients, with the control (HR=1) being the H. pylori-negative group. In the subgroup analysis, the pooled HR was 0.38 (95%CI, 0.24-0.59) for OS in H. pylori-positive patients who received surgery combined with chemotherapy. The pooled HR for disease-free survival was 0.74 (95%CI, 0.63-0.8), and 0.41 (95%CI, 0.26-0.65) in patients received surgery combined with chemotherapy. Conclusions: H. pylori-positive gastric cancer patients have a better overall prognosis than negative patients. Helicobacter pylori infection has improved the prognosis of patients undergoing surgery or chemotherapy, among which the improvement was most obvious in patients undergoing surgery combined with chemotherapy.

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“…4.0 U/mL defined as positive, according to the manufacturer's instructions. Several investigators previously demonstrated the usefulness of these kits (15)(16)(17)(18). At our institution, when eradication therapy is not confirmed to be successful, it is recommended that patients undergo an H. pylori stool antigen test.…”

Section: Methodsmentioning

confidence: 99%

“…When GMA was endoscopically observed, the degree was evaluated using the classification of Kimura and Takemoto, in which GMA is classified into six grades (C1, C2, C3, O1, O2, O3) (22). Cases without GMA were determined to be C0 for this study (16), so the classification of GMA was divided into seven groups (C0 and the grades noted above).…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Raspberry-type Gastric Foveolar-type Tumor in Individuals Undergoing Medical Checkups

et al. 2023

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Objective This study was performed to clarify the prevalence of raspberry-type gastric foveolar-type tumors, along with the time-course changes in the size and clinical course. Materials and MethodsThe subjects were 10,663 consecutive patients who underwent a medical checkup between April 2016 and March 2022, including an esophagogastroduodenoscopy (EGD) examination and determination of Helicobacter pylori infection status (uninfected, positive, post-eradication). The presence of characteristic reddish polypoid lesions in the stomach was investigated, and a diagnosis of raspberry-type gastric foveolar-type tumor was made based on histological findings. Results Thirty-eight cases had gastric polyps with a raspberry-like appearance on endoscopy, with 29 lesions in 28 cases endoscopically and histologically diagnosed as a raspberry-type gastric foveolar-type tumor. All of the affected subjects were determined to be H. pylori-uninfected. The prevalence of this type of lesion in all subjects was 0.26%, while that in the 6,635 H. pylori-uninfected subjects was 0.42%. An older age and the presence of a fundic gland polyp were found to be significant risk factors associated with the occurrence of the tumor. The mean size was 3.8±1.9 (range: 2-10) mm, and the location was in a fundic gland area in all affected subjects. Furthermore, examinations of previous EGD images revealed that two-thirds of the lesions had not changed in size, while follow-up EGD findings showed that lesions ! 5 mm in size had disappeared after a biopsy procedure. ConclusionThe prevalence of raspberry-type gastric foveolar-type tumors was 0.42% in H. pyloriuninfected subjects. More than half of the lesions were too small to be removed by an endoscopic biopsy.

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Serum Anti-<i>Helicobacter pylori</i> IgG Antibody Titer in <i>H. pylori</i>-negative Cases with a Different Gastric Mucosal Atrophy Status

Cited by 6 publications

References 17 publications

Endoscopic findings of cardiac lymphoid hyperplasia and Helicobacter pylori infection status

Endoscopic findings of cardiac lymphoid hyperplasia and Helicobacter pylori infection status

Helicobacter pylori Infection as a Predictor of Treatment Outcomes of Gastric Cancer: A Systematic Review and Meta-Analysis

Prevalence of Raspberry-type Gastric Foveolar-type Tumor in Individuals Undergoing Medical Checkups

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